Results 231 to 240 of about 61,185 (300)

Perspectives for Advancing Biotechnological Succinic Acid Production

Microbial Biotechnology, Volume 19, Issue 5, May 2026.
Succinic acid is an important molecule for sustainable chemical manufacturing, but its industrial production faces high costs and sustainability challenges, which are linked to feedstocks and excessive acid/base consumption. This opinion explores production routes based on next‐generation feedstocks and low‐pH fermentations to inspire novel cost ...
Christoph Gunkel, Bastian Blombach
wiley   +1 more source

Heterogeneity of common carotid artery and abdominal aorta: an angle of sphingolipid metabolism in vascular smooth muscle cells. [PDF]

Biomed Eng Online
Li B, Zhou K, Chen K, Jiang S, Wang X, Gu Z, Gu C, Han Y, Liu Y, Chang Y, Bao J.   +10 more
europepmc   +1 more source

Mitochondrial Homeostasis in Pancreatic β Cell Function: Mechanisms and Therapeutic Targets for Diabetes

Journal of Diabetes, Volume 18, Issue 5, May 2026.
This review highlights mitochondrial dysfunction as a central driver of pancreatic β cell failure in diabetes, caused by disrupted mitochondrial quality control (MQC), oxidative stress, and impaired organelle communication. Emerging therapies, such as DRAK2 inhibitors and metabolic reprogramming agents, show promise in restoring β cell function by ...
Ruihan Li, Bingqian Zhang, Yuxin Zhang, Yang Yang, Yuting Lu, Jingya Li   +5 more
wiley   +1 more source

Discriminative Plasma Lipidomic Signatures of Dementia with Lewy Bodies and Alzheimer's Disease: A Targeted Mass Spectrometry and Machine Learning Approach. [PDF]

Neuropsychiatr Dis Treat
Wen L, Zhang Y, Nie Y, Shen H, Qin Q, Qu M.   +5 more
europepmc   +1 more source

Citrate‐Dependent Activation of Acetyl CoA Carboxylase Promotes Renal Lipid Accumulation in a Rat Model of Chronic Kidney Disease

Acta Physiologica, Volume 242, Issue 5, May 2026.
ABSTRACT Background Abnormal accumulation of lipids within the kidney contributes to the progression of chronic kidney disease, but the underlying metabolic mechanisms remain unclear. Citrate is a central metabolite in cellular energy regulation and is frequently elevated in advanced kidney disease, yet its impact on renal lipid metabolism has not been
Marta Sanz‐Gómez, Beatriz Linillos‐Pradillo, Rubén Fernández de la Rosa, Isabel Aránguez, Reinhold Kreutz, Antonia García, Coral Barbas, Adrián Plaza, María S. Fernández‐Alfonso   +8 more
wiley   +1 more source

Gut sphingolipid composition as a prelude to necrotizing enterocolitis [PDF]

, 2018
Jiang, X., Ory, D. S., Rusconi, B., Sidhu, R., Tarr, P. I., Warner, B. B.   +5 more
core   +1 more source

Potential endogenous lipid ligands for the nuclear receptor transcription factor Steroidogenic Factor-1. [PDF]

Adv Biol Regul
Campbell AN, Blind RD.
europepmc   +1 more source

Upregulation of sphingomyelin and ABCA8 in response to TDP‐43 pathology in amyotrophic lateral sclerosis brain

Brain Pathology, Volume 36, Issue 3, May 2026.
Increases in sphingomyelin in response to TDP‐43 pathology in the disease‐affected motor cortex of amyotrophic lateral sclerosis (ALS) brain. Abstract Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease characterized by the degeneration of motor neurons and the presence of TAR DNA‐binding protein 43 (TDP‐43 ...
Finula I. Isik, Russell Pickford, Nicolas Dzamko, Kerry‐Anne Rye, Woojin Scott Kim   +4 more
wiley   +1 more source

The Role of Sphingolipid Metabolism and Neuron Death in Ischemic Stroke: A New Perspective from Bioinformatics. [PDF]

Brain Behav
Chen ZC, Xu FB, Hu S, Cui Q, Barazarte HA, Zhang J, Suo LN, Gu JJ, Xue JY.   +8 more
europepmc   +1 more source

Advancing IBD Management: A Literature Review on the Role of Non‐Invasive Blood‐Based Biomarkers in Predicting and Assessing Pharmacodynamic Response to Treatment

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Reliable biomarkers that enable noninvasive, longitudinal assessment of disease activity and therapeutic response remain a major unmet need in inflammatory bowel disease (IBD). While colonic biopsies are the gold standard for evaluating mucosal inflammation, their invasive nature and limited spatial and temporal resolution constrain their ...
Mohamed Hassanein, Li Xi, Rathi D. Ryan, Zhan (Harold) Ye, Nessy Tania, Yamato Sano, Joshua Varghese, Diogo Branquinho, Anna Sapone   +8 more
wiley   +1 more source