Results 211 to 220 of about 46,072 (254)

Impact of Dupilumab Therapy on Skin Barrier Function in Patients With Moderate‐to‐Severe Atopic Dermatitis: A Phase IV, Non‐Randomized, Open‐Label, Parallel‐Group Clinical Study

MedComm, Volume 7, Issue 11, November 2026.
This 16‑week study assessed impact of dupilumab on skin barrier function in patients with moderate‑to‑severe atopic dermatitis (AD). Tape‑stripped stratum corneum samples for multi‑omic profiling, alongside transepidermal water loss measurements, were collected from lesional/non‑lesional AD skin and healthy controls at seven time points.
Taoming Liu, Shuting Chen, Weijia Zhao, Dake Di, Jiao Liu, Yuyang Tian, Yurong Luo, Yingping Xu, Ruzeng Xue, Li Ye, Xiaoping Pei, Bihui Yu, Yu Wang, Jiao Zhang, Xiaoling Yu, Wei Wen, Liyan Yuan, Suyun Ji, Claire Hu, Dan Shen, Yiqing Guo, Yunsheng Liang   +21 more
wiley   +1 more source

Sphingolipids associate with the chlamydial nucleoid and mark developmental transitions in Chlamydia trachomatis. [PDF]

Nat Commun
Rühling M, Wagner F, Epprecht T, Köhling PF, Schumacher F, Sachs S, Kersting L, Fink J, Girndt L, Kleuser B, Sauer M, Seibel J, Weiss GL, Rudel T.   +13 more
europepmc   +1 more source

Metabolic Screening and In Silico Investigation of Eucalyptus globulus Essential Oil Bioactives Against DENV‐2 Envelope Protein

ChemistryOpen, Volume 15, Issue 11, November 2026.
Network pharmacology and molecular docking identify bioactive compounds from Eucalyptus globulus essential oil with potential activity against dengue virus, highlighting 70 shared targets and DENV‐2‐associated pathways. Globulol and eucalyptol show strong binding to DENV‐2 receptors, with favorable drug‐likeness and toxicity profiles, supporting their ...
Arslan Afzal, Ilyas Ahmad, Mahadullah, Saliha Qamar, Tayyaba Yousaf, Faiz Ullah, Dilawar Khan, Mohammad Hamid Hamdard, Zia ur Rehman Mashwani   +8 more
wiley   +1 more source

Sphingolipid metabolism and hematologic disorders: current understanding and future directions. [PDF]

Front Physiol
Kuang Z, Huang T, Chen G.
europepmc   +1 more source

Asthma: From Phenotypes to Endotypes—Beyond Type 2 Inflammation

Respirology, Volume 31, Issue 11, Page 1077-1090, November 2026.
ABSTRACT Asthma is a heterogeneous syndrome featuring variable pathophysiology, clinical presentation and treatment response. This review examines a comprehensive endotype‐phenotype framework for asthma assessment with an emphasis on characteristics beyond T2 inflammatory status alone.
Mario Fernando, Gregory G. King
wiley   +1 more source

Transport of sphingolipids by yeast Npc2 supports phase separation of the vacuole membrane. [PDF]

J Biol Chem
Kim H, Lipp NF, Juarez-Contreras I, Wong AM, Budin I.   +4 more
europepmc   +1 more source

Environmental Mycotoxins and Brain Health: Protective Role of Bromelain Against Fumonisin B1 in SH‐SY5Y Cells

Environmental Toxicology, Volume 41, Issue 11, Page 1188-1200, November 2026.
ABSTRACT Fumonisin B1 (FB1), a mycotoxin commonly found in contaminated food and feed, has been increasingly implicated in neurotoxicity, although its mechanisms remain poorly understood. This study investigates the neurotoxic potential of FB1 in human SH‐SY5Y neuroblastoma cells, both undifferentiated and RA‐differentiated, and evaluates the ...
Gianluca Antonio Franco, Francesca Inferrera, Nicla Tranchida, Davide Di Paola, Roberta Fusco, Salvatore Cuzzocrea, Enrico Gugliandolo   +6 more
wiley   +1 more source

Fungal Sphingolipids: Biosynthesis Pathways, Structural Features and Biological Functions. [PDF]

J Fungi (Basel)
Xue Z, Wang L, Du C.
europepmc   +1 more source

Metabolic shifts driven by host-microbial interactions. [PDF]

FEBS J
Nair T, Stuhr NL, Weathers BA, Curran SP.   +3 more
europepmc   +1 more source

Tree Shrew as an Emerging Model for Aging Research: Characterization of Senescence and Therapeutic Interventions

Aging Cell, Volume 25, Issue 11, November 2026.
Compared with mouse cells, tree shrew fibroblasts more faithfully recapitulate the hallmarks of human cellular senescence. In vivo, aged tree shrews exhibit transcriptomic signatures of aging across multiple organs that closely mirror those observed in humans.
Qiuni Luo, Wenxian Xiao, Xin Dong, Ayesha Nisar, Yuhua Ma, Xiang Lai, Raoxian Bai, Meiting Zi, Qi Geng, Qingyu Zhang, Cheng Zhang, Qiong Wang, Naheemat Modupeola Gold, Zhen Zhou, Li Hu, Ao Zhang, Qinghua Zeng, Jing Liu, Sawar Khan, Longbao Lv, Yonghan He   +20 more
wiley   +1 more source