Results 191 to 200 of about 41,788 (297)

Metabolome analysis identified exogenous cholesterol within lipid rafts that activate the Akt/mTOR signaling pathway in epithelial ovarian cancer

International Journal of Cancer, Volume 159, Issue 1, Page 257-268, 1 July 2026.
What's New? Epithelial ovarian cancer (EOC) is a severe malignancy with few effective treatment options. While the mechanisms remain unclear, changes in lipid metabolism may fuel tumor growth and EOC progression, offering a possible path for new treatments.
Hitomi Sakaguchi‐Mukaida, Kosuke Hiramatsu, Tatsuo Masuda, Mamoru Kakuda, Satoshi Nakagawa, Tadashi Iwamiya, Shinya Matsuzaki, Tetsuji Naka, Yutaka Ueda, Tadashi Kimura, Michiko Kodama   +10 more
wiley   +1 more source

Sinbaglustat is efficacious in GM2 gangliosidosis primarily through inhibition of GBA2 rather than GCS. [PDF]

Mol Ther Adv
Steiner MA, Vaillant C, Garzotti M, Gulinello M, VanBrakle ML, Ryge J, Mühlemann A, Dobrenis K, Welford RWD.   +8 more
europepmc   +1 more source

A Step‐by‐Step Protocol From METASPACE to Biological Interpretation

Journal of Mass Spectrometry, Volume 61, Issue 7, July 2026.
ABSTRACT Mass spectrometry imaging (MSI) represents an exceptional tool for exploring complex biological systems spatially at the molecular level. However, its multidimensional nature and large data outputs make it challenging to extract meaningful biological insights. Advancements such as the METASPACE platform allow researchers to efficiently process,
Abigail Moreno‐Pedraza, Brittney Gorman, Marija Velickovic, Max Bentelspacher, Jaime Barros, Dusan Velickovic, Christopher R. Anderton   +6 more
wiley   +1 more source

Proteome Responses to Acute Inhibition of De Novo Sphingolipid Synthesis Suggest Cancer Combination Therapies. [PDF]

Cancers (Basel)
Luu TTT, Zhang D, Bheemanapally K, Zaman M, Wu Z, Liu Y, Wu X, Kim HE, Zheng L, Ogretmen B, Peng J, Du G.   +11 more
europepmc   +1 more source

Global Fluoride Toxicology Landscape: Bibliometric Approaches and Scientific Mapping

Environmental Toxicology, Volume 41, Issue 7, Page 416-458, July 2026.
ABSTRACT This study analyzed research trends in the 100 most‐cited articles on fluoride toxicology, a topic widely debated due to the toxic effects associated with levels deemed safe for human exposure. A bibliometric analysis was conducted using the Web of Science‐Core Collection, extracting data such as citation count, authors, keywords, journal ...
Maria Karolina Martins Ferreira, Deiweson Souza‐Monteiro, Priscila Cunha Nascimento, Luciana Eiró‐Quirino, Leonardo Oliveira Bittencourt, Fatemeh Vida Zohoori, Esperanza Angeles Martinez‐Mier, Marilia Afonso Rabelo Buzalaf, Rafael Rodrigues Lima   +8 more
wiley   +1 more source

High-resolution sphingolipid analysis in vitro using LC-qToF MS. [PDF]

Methods Enzymol
Chitkara S, Atilla-Gokcumen GE.
europepmc   +1 more source

COCHLEATA controls spatial regulation of cytokinin and auxin during nodule development

New Phytologist, Volume 251, Issue 1, Page 228-244, July 2026.
Nodule development defects in the coch mutant include root‐like structures, reduced colonisation, and vascular disorganisation. Summary Root nodules host nitrogen‐fixing bacteria and likely evolved through modifications of the lateral root program. Members of the NOOT‐BOP‐COCH‐LIKE transcriptional coregulator family suppress root identity in nodules ...
Karen Velandia, Muhammad Nouman Sohail, Tiana E. Scott, Alejandro Correa‐Lozano, Alannah Mannix, Eloise Foo   +5 more
wiley   +1 more source

Bovine Milk Polar Lipids: Lipidomics Advances and Functional Perspectives. [PDF]

Foods
Fappani G, Liu Z, Rochfort S, Rocchetti G.   +3 more
europepmc   +1 more source

Soybean Inositol Polyphosphate 5‐Phosphatase 8 Confers Salt Tolerance by Reducing Sodium Influx Through Inositol 1,4,5‐Trisphosphate Signalling

Plant, Cell &Environment, Volume 49, Issue 7, Page 4420-4434, July 2026.
ABSTRACT Evidence suggests that the metabolism of inositol and its derivatives may be involved in various biological processes including salt tolerance, but there has been limited understanding. Ectopic expression of Gs5PTase8, an inositol polyphosphate 5‐phosphatase cloned from wild soybean (Glycine soja), significantly enhanced salt tolerance in ...
Qi Jia, Yuan Chen, Defeng Kong, Hanyu Fan, Song Sun, Yuhang Liu, Jiahui Fu, Man‐Wah Li, Fuk‐Ling Wong, Qinghua Li, Kangjing Liang, Hon‐Ming Lam, Wen‐Xiong Lin   +12 more
wiley   +1 more source

Dysregulated metabolism of ceramides and glycosphingolipids in Parkinson's disease. [PDF]

J Lipid Res
Peng YF, Chen SJ, Li JL, Lin CH, Kuo CH.
europepmc   +1 more source