Results 221 to 230 of about 46,072 (254)

Dialysis Dose and Flux as Potential Effect Modifiers of Sphingolipid-Mortality Associations. [PDF]

J Am Soc Nephrol
Zhao Q, Yang Y, Liu X, Chen J, Chen J.
europepmc   +1 more source

MKP‐2 Genetic Depletion Modulates Adipose Lipid Composition, Cellular Senescence, and Aging in Mice

Aging Cell, Volume 25, Issue 11, November 2026.
Excess white adipose tissue (WAT) accumulation promotes aging by increasing the risk of insulin resistance and chronic diseases and reduced lifespan. MKP‐2 deficiency protects against premature senescence in cells and WAT and is associated with adipose lipid remodeling, improved metabolic health, and longer lifespan.
Morgan Welch, Nabin Ghimire, Shauri Smith, Cassandra Secunda, Alexis Fink, Alissar Sleiman, Laura Chambliss, Christopher Pinckard, Chloe Reyes, Priya Katta, Anna Ai, Benjamin R. Harrison, Ahmed Lawan   +12 more
wiley   +1 more source

Serum Lipidomics Profiling Identify Novel Biomarkers of Distal Symmetrical Polyneuropathy in Type 1 Diabetes

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 10670-10682, November 2026.
ABSTRACT Background Distal symmetrical polyneuropathy (DSPN) is a common complication of type 1 diabetes (T1D), yet validated biomarkers for early detection or prognosis are lacking. Metabolic disturbances driven by chronic hyperglycemia and dyslipidemia contribute to DSPN development and progression.
Tik Muk, Tina Okdahl, Marietta Kokla, Tommi Suvitaival, Gurjeet Kaur, Ismo M. Mattila, Simon M. Kienle, Christian Buhl, Knud Yderstræde, Troels S. Jensen, Peter Rossing, Flemming Pociot, Birgitte Brock, Cristina Legido‐Quigley, Páll Karlsson, Christian S. Hansen, Christina Brock, Joachim Størling, Karolina Sulek   +18 more
wiley   +1 more source

Metabolic Profiling of Circulating and Tumour‐Infiltrating T Cells Uncovers Bioenergetic Checkpoints Linked With Immune and Clinical Skewing in Melanoma Patients

Immunology, Volume 179, Issue 3, Page 486-515, November 2026.
In this study, we revealed the disturbed metabolic status of circulating and tumour‐infiltrating CD4+ and CD8+ T cells in melanoma patients through targeted metabolomic and lipidomic (on sorted subsets) and at single cell level using the SCENITH method.
Hugo Brouque, Kareem Mahdy, Stephane Mouret, Sylvain Henry, Camille Niveau, Mélanie Cettour‐Cave, Martin Pelosse, Florence de Fraipont, Julie Charles, Andrei Turtoi, Philippe Saas, Caroline Aspord   +11 more
wiley   +1 more source

Lipid metabolism dysregulation in late-life depression: peripheral metabolic disturbance, central lipid alterations, and dietary modulation. [PDF]

Front Nutr
Gao Y, Li HN, Li ZK, Hu JZ, Du XZ, Yan X, Liu S.   +6 more
europepmc   +1 more source

Cargo Stability of Extracellular Vesicles Derived From Non‐Diseased Sources: Effects of Storage and Handling Conditions

Journal of Cellular and Molecular Medicine, Volume 30, Issue 21, November 2026.
ABSTRACT Extracellular vesicles (EVs) are nanoscale, membrane‐enclosed particles that transfer proteins, nucleic acids, lipids, and other bioactive molecules between cells. Their cargo‐bearing capacity supports applications in drug delivery, regenerative medicine, and biomarker development, but ex vivo handling can alter vesicle recovery and cargo ...
Khadijeh Abbasi, Mina Mohammadinasr, Roza Motavalli, Narges Arianfar, Attabak Toofani‐Milani, Moein Shirzad, Vahid Hosseini, Masoud Darabi   +7 more
wiley   +1 more source

Unexpected Suppression of Tomato Fruit Cuticle Formation by Overexpression of a Key Cutin Biosynthetic Enzyme

Plant Biotechnology Journal, Volume 24, Issue 11, Page 5760-5773, November 2026.
ABSTRACT Fruit cuticles regulate the diffusion of water, gases and solutes, functioning as essential protective interfaces against environmental and biotic stresses. Engineering cuticle structure and mechanics therefore represents a promising strategy for improving fruit quality and resilience.
Gulab Chand Arya, Ekram Wassel, Vibha Mishra, Ekaterina Manasherova, Ruth E. Stark, Hagai Cohen   +5 more
wiley   +1 more source

Cross-model metabolomic signatures of dietary anti-inflammatory (poly) phenols in nutraceutical development: a systematic review. [PDF]

Front Mol Biosci
Fayomi A, Adom E, Aryee ANA.
europepmc   +1 more source

Sorghum Metabolic Atlas: A fluorescent protein‐based subcellular localization resource for sorghum enzymes

The Plant Journal, Volume 128, Issue 3, November 2026.
SUMMARY Plant metabolism drives traits essential for productivity and resilience, yet understanding metabolic networks requires subcellular, cellular, and tissue‐level spatial context that remains limited, particularly in crop species. Experimentally derived subcellular localization data for enzymes are sparse, constraining analyses of metabolic ...
Purva Karia, William P. Dwyer, Ava Kloss‐Schmidt, Charles Hawkins, Bo Xue, Daniel Ginzburg, Maxine L. Gutierrez, Ritesh Mewalal, Ian Blaby, David W. Ehrhardt, Seung Y. Rhee   +10 more
wiley   +1 more source

Ceramide in Type 2 Diabetes and Obesity: Modulation by Nutrients and Dietary Patterns and Opportunities to Prevent and/or Manage Metabolic-Related Conditions. [PDF]

Metabolites
Gaggini M, Suman AF, Vassalle C.
europepmc   +1 more source