Results 71 to 80 of about 8,799 (216)
Coupled assay of sphingomyelin and ceramide molecular species by gas liquid chromatography
Journal of Lipid Research, 2002 This study reports a single-step analysis of the molecular species of endogenous ceramides and of the ceramide moiety of sphingomyelins in biological samples, using gas liquid chromatography (GLC).
Claude Vieu +8 more
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Secreted sphingomyelins modulate low mammary cancer incidence observed in certain mammals
Scientific Reports, 2020 Determining mechanisms that naturally protect species from developing cancer is critical in order to prevent and treat cancer. Here, we describe a novel cancer-suppressing mechanism, via the secretion of bioactive factors by mammary cells, that is ...
Melissa M. Ledet +6 more
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Interdisciplinary Medicine, EarlyView.In normal pregnancy, PEVs help maintain maternal–fetal immune tolerance while enabling controlled immune activation, promote endothelial migration, and support trophoblast invasion and syncytialization, strengthening antimicrobial defense. In pregnancy‐related disorders, dysregulated PEV signaling may drive endothelial dysfunction and hypertension, BBB
Jiale Du +5 more
wiley +1 more source
PLoS ONE, 2015 ObjectiveAlthough metabolic profiles have been associated with chronic disease risk, lack of temporal stability of metabolite levels could limit their use in epidemiological investigations.
Marion Carayol +9 more
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Interdisciplinary Medicine, EarlyView.Engineered extracellular vesicles (EVs) offer a versatile platform for kidney‐targeted therapy. This review summarizes bioengineering strategies, including cargo loading, surface modification, biomimetic fabrication, and biomaterial integration. We highlight translational challenges and propose future solutions to accelerate the clinical application of
Linru Shi +6 more
wiley +1 more source
Research Advances in Regulatory Effect of Phospholipids on Meat Quality [PDF]
Shipin KexuePhospholipids, a class of polar lipids with complex structure and multiple functions, are composed of glycerophospholipids and sphingomyelins. As an important component of cell membranes, phospholipids are involved in many physiological activities, such ...
ZHANG Kaihua, ZANG Mingwu, Wang Shouwei, ZHANG Zheqi, LI Dan, LI Xiaoman, HAO Rui
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Nano Delivery Strategy Opens Effective Avenues for the Treatment of Colorectal Cancer
Medicine Bulletin, EarlyView.ABSTRACT Colorectal cancer (CRC) presents significant therapeutic challenges because of chemoresistance, systemic toxicity, and the complexity of the tumor microenvironment (TME). Nanodrug delivery systems (NDDS) have emerged as versatile platforms capable of overcoming these limitations by enhancing tumor accumulation, improving pharmacokinetics, and ...
Qiurong Wei +7 more
wiley +1 more source
Low serum sphingolipids in children with attention deficit-hyperactivity disorder
Frontiers in Neuroscience, 2015 Background: Attention deficit-hyperactivity disorder (ADHD) is the most prevalent neuropsychiatric condition in childhood. ADHD is a multifactorial trait with a strong genetic component. One neurodevelopmental hypothesis is that ADHD is associated with a
Marcela Patricia Henríquez-Henríquez +6 more
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Uncovering the Complexity of Synucleinopathies: An Ongoing Tale Between Proteins and Lipids
Movement Disorders, EarlyView.Abstract Neurodegenerative diseases are pathological states characterized by progressive alterations in brain homeostasis during aging. Synucleinopathies, including Parkinson's disease and dementia with Lewy bodies, are defined neuropathologically by the accumulation of inclusions known as Lewy bodies and Lewy neurites.
Manuel Flores‐León, Tiago F. Outeiro
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The Journal of Pathology, EarlyView.Abstract Ceramide deficiency in the stratum corneum (SC) is a key etiological factor in atopic dermatitis (AD). To clarify the direct role of SC ceramide depletion in impairing SC barrier and water‐holding functions and in initiating AD‐like skin symptoms and disease‐specific molecular alterations, we generated Tg mice overexpressing a mutant form of ...
Mariko Takada +8 more
wiley +1 more source