Results 101 to 110 of about 35,942 (184)

Comorbidities at MS Diagnosis and Their Association With Treatment Persistence: Real‐World Clinical Data

Brain and Behavior, Volume 16, Issue 2, February 2026.
Comorbidity was present in approximately half of the patients with relapsing‐remitting multiple sclerosis in this Finnish cross‐sectional cohort. Comorbidities, especially psychiatric diseases, were associated with lower persistence on injectable disease‐modifying treatments.
Henrik Ahvenjärvi, Ida Lund, Anne M. Portaankorva, Johanna Krüger, Mervi Ryytty   +4 more
wiley   +1 more source

Metabolic reprogramming of efferocytosis in the tumour microenvironment: From apoptotic‐cell clearance to therapeutic targeting

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
This review systematically deconstructs the pathological efferocytic—metabolic axis in tumours, framing it as a three‐stage, self‐reinforcing cycle: from metabolite‐driven macrophage recruitment, through hijacked surface recognition, to post‐phagocytic metabolic reprogramming that locks in immunosuppression.
Qianlu Yang, Jie Yan, Qianxi Yang
wiley   +1 more source

Exocarpium Citri Grandis‐Derived Extracellular Vesicle‐Like Particles for Accelerating Wound Healing via Regulating the Protein Expression on the VEGF/AKT Signaling Pathway

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Our findings indicate that ECG‐EVLP can effectively promote wound healing and the activation of the VEGF/AKT signaling pathway in vitro and in vivo, coupled with the inhibition of the mitochondrial apoptosis pathway in cells following ECG‐EVLP stimulation might be its underlying mechanism.
Yingjie Xiong, Zanxiang Luo, Jingxiu Zhao, Chengshi Fu, Yujia Song, Jinyong He, Jiahui Gao, Zejie Su, Lie Liu, Xiangyun Teng, Jianhua Xu   +10 more
wiley   +1 more source

Lipidomic Analysis of Plasma Extracellular Vesicles from Adiponectin Deficient Mice or Metabolic Syndrome Patients Reveals Pro‐Oxidative and Pro‐Inflammatory Lipid Signatures Correlating with Metabolic Dysfunction

Journal of Extracellular Vesicles, Volume 15, Issue 2, February 2026.
Adiponectin deficiency remodels the lipid composition of plasma extracellular vesicles (EV), enriching polyunsaturated phospholipids and reducing lysophospholipids. These remodelled EV impact oxidative, inflammatory and metabolic function in recipient cells.
Sungji Cho, Hye Kyoung Sung, Khang Nguyen, Yubin Lei, Sivaporn Wannaiampikul, Brian Lee, Eddie Tam, Yihan Luo, Evgeniy V. Petrotchenko, Christoph H. Borchers, Kacey J. Prentice, Scott A Summers, Dylan Burger, Gary Sweeney   +13 more
wiley   +1 more source

Ventilator‐Induced Lung Injury: Mechanotransduction and Potential Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Mechanical ventilation (MV) is expected to undergo significant transformative advancements by 2050, with the emergence of personalized ventilation systems that promise to revolutionize respiratory care. However, the risk of ventilator‐induced lung injury (VILI) remains a significant concern at this stage and VILI still exists at that time.
He Ren, Ziqi Shang, Alastair G. Stewart, Ying‐xin Qi, Kai Huang   +4 more
wiley   +1 more source

Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
This figure emphasizes current understanding of the regulatory networks, approach of diagnose, available preclinical models and clinical management of bone metastasis. to guide future therapeutic development. A deep understanding of these aspects enables the prevention of bone metastasis and the implementation of effective therapeutic strategies ...
Jingyuan Wen, Binghua Li, Shengjia Wang, Yongzhong Yao, Zhao Huang, Decai Yu   +5 more
wiley   +1 more source

The Crystal Structure of Human Transport and Golgi Organization 2 Homolog (TANGO2) Protein Reveals an αββα‐Fold Arrangement

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 2, Page 515-528, February 2026.
ABSTRACT Transport and Golgi Organization 2 Homolog (TANGO2) protein deficiency disorder (TDD) is a rare autosomal recessive disorder characterized by multi‐systemic abnormalities and significant phenotypic variability including neurodevelopmental delay, seizures, intermittent ataxia, hypothyroidism, rhabdomyolysis, life‐threatening metabolic ...
Anne Cooper, Alyssa Powers, Kevin P. Battaile, Al‐Walid Mohsen, David K. Johnson, Scott Lovell, Lina Ghaloul‐Gonzalez   +6 more
wiley   +1 more source

Skin Lipid–Microbe Interplay Links Staphylococcus hominis to Barrier Control in Adult Atopic Dermatitis

Allergy, Volume 81, Issue 2, Page 454-467, February 2026.
This study investigates mutual interaction of skin microbes and surface lipids in AD using the advanced method of shotgun lipidomics with ultra‐broad coverage of lipids and 16S amplicon sequencing of tape strips taken from lesional and non‐lesional AD and healthy controls.
Madhumita Bhattacharyya, Felix Lauffer, Manja Jargosch, Kristina Frey, Mahsa Shahidi Dadras, Theresa Raunegger, Sophia Wasserer, Carsten B. Schmidt‐Weber, Tilo Biedermann, Kilian Eyerich, Stefanie Eyerich, Claudia Traidl‐Hoffmann, Christian Klose, Matthias Reiger, Natalie Garzorz‐Stark   +14 more
wiley   +1 more source

Non‐Coding RNAs in Breast Cancer Radioresistance: Mechanisms, Functional Roles and Translational Potentials

Cell Proliferation, Volume 59, Issue 2, February 2026.
Non‐coding RNAs (ncRNAs) regulate breast cancer radioresistance via cell cycle, DNA repair and tumour microenvironment pathways. Targeting ncRNAs (e.g., HOTAIR and miR‐155) with RNA‐based therapies (ASOs and CRISPR) shows promise but faces delivery challenges.
Xiaohui Zhao, Yuting Qiu, Jie Chen, Danni Wang, Zairui Wang, Shuang Ma, Yimin Liu, Guoying Liu, Zhuofei Bi   +8 more
wiley   +1 more source

Psychosine Alleviates Colitis via Inhibiting Th1 and Th17 Cell Immune Responses in Inflammatory Bowel Diseases

Journal of Gastroenterology and Hepatology, Volume 41, Issue 2, Page 686-695, February 2026.
ABSTRACT Background Aberrant T‐helper 1 (Th1) and Th17 cell activation is involved in the pathogenesis of inflammatory bowel disease (IBD). Psychosine is known to induce apoptosis, promote astrocyte activation, and inhibit osteoclastogenesis. However, the role of psychosine on Th1 and Th17 cell immune responses has not been previously reported. In this
Ritian Lin, Jiayi Tu, Shan Li, Qinjuan Sun, Lan Zhong   +4 more
wiley   +1 more source