Results 1 to 10 of about 47,887 (228)

Mouse Sphingosine Kinase 1a Is Negatively Regulated through Conventional PKC-Dependent Phosphorylation at S373 Residue. [PDF]

PLoS ONE, 2015
Sphingosine kinase is a lipid kinase that converts sphingosine into sphingosine-1-phosphate, an important signaling molecule with intracellular and extracellular functions.
Yong-Seok Oh, Sun Sik Bae, Jong Bae Park, Sang Hoon Ha, Sung Ho Ryu, Pann-Ghill Suh   +5 more
doaj   +7 more sources

Sphingosine 1-phosphate receptors and sphingosine kinase 1: novel biomarkers for clinical prognosis in breast, prostate, and hematological cancers [PDF]

Frontiers in Oncology, 2012
There is substantial evidence for a role in cancer of the bioactive lipid sphingosine 1-phosphate (S1P), the enzyme sphingosine kinase 1 (that catalyses S1P formation) and S1P-specific G protein coupled receptors.
Susan ePyne, Joanne eEdwards, Jan eOhotski, Nigel John Pyne   +3 more
doaj   +3 more sources

The sphingosine‐1‐phosphate signaling pathway (sphingosine‐1‐phosphate and its receptor, sphingosine kinase) and epilepsy [PDF]

Epilepsia Open
Epilepsy is one of the common chronic neurological diseases, affecting more than 70 million people worldwide. The brains of people with epilepsy exhibit a pathological and persistent propensity for recurrent seizures.
Lin Wang, Qingxia Kong, Xinyi Leng, Howan Leung, Yang Li   +4 more
doaj   +2 more sources

Sphingosine kinases : emerging structure function insights [PDF]

Trends in Biochemical Sciences, 2016
Sphingosine kinases (SK1 and SK2) catalyse the conversion of sphingosine into sphingosine 1-phosphate and control fundamental cellular processes, including cell survival, proliferation, differentiation, migration, and immune function.
Adams, David R., Pyne, Nigel J., Pyne, Susan   +2 more
core   +5 more sources

Inhibition of Sphingosine Kinase 2 Results in PARK2-Mediated Mitophagy and Induces Apoptosis in Multiple Myeloma [PDF]

Current Oncology, 2023
Mitophagy plays an important role in maintaining mitochondrial homeostasis by clearing damaged mitochondria. Sphingosine kinase 2 (SK2), a type of sphingosine kinase, is an important metabolic enzyme involved in generating sphingosine-1-phosphate.
Jian Wu, Shengjun Fan, Daniel Feinberg, Xiaobei Wang, Shaima Jabbar, Yubin Kang   +5 more
doaj   +2 more sources

The Functional Role of Sphingosine Kinase 2

Frontiers in Molecular Biosciences, 2021
Sphingosine-1-phosphate (S1P) is a bioactive lipid molecule that is present in all eukaryotic cells and plays key roles in various extracellular, cytosolic, and nuclear signaling pathways. Two sphingosine kinase isoforms, sphingosine kinase 1 (SPHK1) and
Rocio Diaz Escarcega, Louise D. McCullough, Louise D. McCullough, Andrey S. Tsvetkov, Andrey S. Tsvetkov, Andrey S. Tsvetkov   +5 more
doaj   +1 more source

Drugging Sphingosine Kinases [PDF]

ACS Chemical Biology, 2014
The transfer of the gamma phosphate from ATP to sphingosine (Sph) to generate a small signaling molecule, sphingosine 1-phosphate (S1P), is catalyzed by sphingosine kinases (SphK), which exist as two isoforms, SphK1 and SphK2. SphK is a key regulator of S1P and the S1P:Sph/ceramide ratio.
Santos, Webster L., Lynch, Kevin R.
openaire   +2 more sources

Sphingosine 1-phosphate modulates antigen capture by murine langerhans cells via the S1P2 receptor subtype [PDF]

, 2012
Dendritic cells (DCs) play a pivotal role in the development of cutaneous contact hypersensitivity (CHS) and atopic dermatitis as they capture and process antigen and present it to T lymphocytes in the lymphoid organs.
A Kihara, A Kissenpfennig, A Kumar, A Martino, A Olivera, A Weigert, AD Christensen, Burkhard Kleuser, C Ocana-Morgner, C Ruedl, CC Norbury, CL Bennett, CL Bennett, DH Kaplan, DH Kaplan, E Guaguere, ES Trombetta, EY Seo, F Sparber, G Gollmann, G Schuhmachers, H Hackstein, H Liu, Heinfried H. Radeke, HH Radeke, I Reines, J Chun, Jagadeesh Bayry, JH Hong, K Kabashima, K Sarkar, K Takabe, Katrin Schaper, L Japtok, L Rose, L Ruwisch, LS Bursch, Lukasz Japtok, M Hara-Chikuma, M Matloubian, M Schröder, M Schuppel, MB Lutz, MC Kerr, ML Allende, ML Allende, N Romani, P Mitra, P Monti, R van de Ven, RH Kim, RM Steinman, S Spiegel, S Sullivan, S Xu, Se Kyoo Jeong, SH Wood, SP Zahner, T Hla, T Kitajima, T Walzer, V Brinkmann, W Baumer, W Baumer, W Baumer, Wolfgang Bäumer, Y Maeda, Y Yanagawa, YY Lan   +68 more
core   +9 more sources

Insulin protects apoptotic cardiomyocytes from hypoxia/reoxygenation injury through the sphingosine kinase/sphingosine 1-phosphate axis. [PDF]

PLoS ONE, 2013
OBJECTIVE: Experimental and clinical studies have shown that administration of insulin during reperfusion is cardioprotective, but the mechanisms underlying this effect are still unknown.
Huan Yu, Xiangxin Che, Xiaoyuan Xu, Meirong Zheng, Yong Zhao, Wei He, Jingmou Yu, Jianjun Xiong, Weidong Li   +8 more
doaj   +1 more source

Leptin signalling, obesity and prostate cancer: molecular and clinical perspective on the old dilemma [PDF]

, 2015
The prevalence of global obesity is increasing. Obesity is associated with general cancer-related morbidity and mortality and is a known risk factor for development of specific cancers.
Alfraidi, Albandri, Alshaker, Heba, Muhammad, Aun, Pchejetski, Dmitri, Sacco, Keith, Winkler, Mathias   +5 more
core   +8 more sources