Results 11 to 20 of about 371,184 (271)

Impairment of Angiogenic Sphingosine Kinase-1/Sphingosine-1-Phosphate Receptors Pathway in Preeclampsia. [PDF]

PLoS ONE, 2016
Preeclampsia (PE), is a serious pregnancy disorder characterized in the early gestation by shallow trophoblast invasion, impaired placental neo-angiogenesis, placental hypoxia and ischemia, which leads to maternal and fetal morbidity and mortality.
Aneta Dobierzewska, Macarena Palominos, Marianela Sanchez, Michael Dyhr, Katja Helgert, Pia Venegas-Araneda, Stephen Tong, Sebastian E Illanes   +7 more
doaj   +7 more sources

Sphingosine Kinase 1 and Sphingosine-1-Phosphate Signaling in Colorectal Cancer [PDF]

International Journal of Molecular Sciences, 2017
Sphingosine kinase 1 (Sphk1) is a highly conserved lipid kinase that phosphorylates sphingosine to form sphingosine-1-phosphate (S1P). Growing studies have demonstrated that Sphk1 is overexpressed in various types of solid cancers and can be induced by ...
Yonghua Bao, Yongchen Guo, Chenglan Zhang, Fenghua Fan, Wancai Yang   +4 more
semanticscholar   +3 more sources

The sphingosine‐1‐phosphate signaling pathway (sphingosine‐1‐phosphate and its receptor, sphingosine kinase) and epilepsy

Epilepsia Open
Epilepsy is one of the common chronic neurological diseases, affecting more than 70 million people worldwide. The brains of people with epilepsy exhibit a pathological and persistent propensity for recurrent seizures.
Lin Wang, Qingxia Kong, Xinyi Leng, Howan Leung, Yang Li   +4 more
doaj   +3 more sources

Sphingosine and Sphingosine Kinase 1 Involvement in Endocytic Membrane Trafficking* [PDF]

Journal of Biological Chemistry, 2017
The balance between cholesterol and sphingolipids within the plasma membrane has long been implicated in endocytic membrane trafficking. However, in contrast to cholesterol functions, little is still known about the roles of sphingolipids and their metabolites.
Santiago Lima, S. Milstien, S. Spiegel
semanticscholar   +3 more sources

Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics [PDF]

, 2014
Sphingosine 1-phosphate (S1P) is a bioactive lipid that is formed by the phosphorylation of sphingosine and catalysed by sphingosine kinase 1 (SK1) or sphingosine kinase 2 (SK2).
Beak, Dong Jae, Bertaina,, Bertaina, Alice, Bittman, Robert, Chiarini, Francesca, Evangelisti, Camilla, Evangelisti, Cecilia, Falconi, Mirella, Locatelli, Franco, Martelli, Alberto M., Melchionda, Fraia, NC DOCKS at East Carolina University, Pession, Andrea, Pyne, Nigel J., Pyne, Susan, Teti, Gabriella   +15 more
core   +7 more sources

Insulin protects apoptotic cardiomyocytes from hypoxia/reoxygenation injury through the sphingosine kinase/sphingosine 1-phosphate axis. [PDF]

PLoS ONE, 2013
OBJECTIVE: Experimental and clinical studies have shown that administration of insulin during reperfusion is cardioprotective, but the mechanisms underlying this effect are still unknown.
Huan Yu, Xiangxin Che, Xiaoyuan Xu, Meirong Zheng, Yong Zhao, Wei He, Jingmou Yu, Jianjun Xiong, Weidong Li   +8 more
doaj   +1 more source

Resistance of melanoma to immune checkpoint inhibitors is overcome by targeting the sphingosine kinase-1

Nature Communications, 2020
Immune checkpoint inhibitors (ICIs) have dramatically modified the prognosis of several advanced cancers, however many patients still do not respond to treatment.
C. Imbert, A. Montfort, M. Fraisse, E. Marcheteau, J. Gilhodes, E. Martin, Florie Bertrand, M. Marcellin, O. Burlet-Schiltz, A. G. Peredo, Virginie Garcia, S. Carpentier, S. Tartare-Deckert, P. Brousset, P. Rochaix, F. Puisset, T. Filleron, N. Meyer, L. Lamant, T. Levade, B. Ségui, N. Andrieu-Abadie, C. Colacios   +22 more
semanticscholar   +1 more source

Sphingosine Kinase 1/S1P Signaling Contributes to Pulmonary Fibrosis by Activating Hippo/YAP Pathway and Mitochondrial Reactive Oxygen Species in Lung Fibroblasts

International Journal of Molecular Sciences, 2020
The sphingosine kinase 1 (SPHK1)/sphingosine–1–phosphate (S1P) signaling axis is emerging as a key player in the development of idiopathic pulmonary fibrosis (IPF) and bleomycin (BLM)-induced lung fibrosis in mice.
L. Huang, T. Sudhadevi, P. Fu, Prasanth-Kumar Punathil-Kannan, D. Ebenezer, R. Ramchandran, Vijay Putherickal, P. Cheresh, Guofei Zhou, Alison W. Ha, A. Harijith, D. Kamp, V. Natarajan   +12 more
semanticscholar   +1 more source

Identification of Sphingosine Kinase-1 Inhibitors from Bioactive Natural Products Targeting Cancer Therapy

ACS Omega, 2020
Sphingosine kinase 1 (SphK1) is an oncogenic lipid kinase that catalyzes the formation of sphingosine-1-phosphate via phosphorylation of sphingosine and known to play a crucial role in angiogenesis, lymphocyte trafficking, signal transduction pathways ...
D. Jairajpuri, Taj Mohammad, Kirti Adhikari, Preeti Gupta, G. Hasan, M. Alajmi, M. Rehman, A. Hussain, M. Hassan   +8 more
semanticscholar   +1 more source

Discovery of Harmaline as a Potent Inhibitor of Sphingosine Kinase-1: A Chemopreventive Role in Lung Cancer

ACS Omega, 2020
The sphingosine kinase-1/sphingosine-1-phosphate pathway is linked with the cancer progression and survival of the chemotherapy-challenged cells. Sphingosine kinase-1 (SphK1) has emerged as an attractive drug target, but their inhibitors from natural ...
Sonam Roy, Taj Mohammad, Preeti Gupta, Rashmi Dahiya, S. Parveen, Suaib Luqman, G. Hasan, M. Hassan   +7 more
semanticscholar   +1 more source