The Tumorigenic Effect of Sphingosine Kinase 1 and Its Potential Therapeutic Target
Cancer Control: Journal of the Moffitt Cancer Cente, 2020 Sphingosine kinase 1 (SPHK1) regulates cell proliferation and survival by converting sphingosine to the signaling mediator sphingosine 1-phosphate (S1P).
Xianwang Wang +12 more
semanticscholar +1 more source
The Relationship of Sphingosine Kinase 1 With Pyroptosis Provides a New Strategy for Tumor Therapy
Frontiers in Immunology, 2020 Sphingosine kinase 1 (SPHK1) is a crucial molecule that catalyzes sphingosine to synthesize sphingosine-1-phosphate (S1P), facilitating cell survival signaling.
Xianwang Wang +3 more
semanticscholar +1 more source
Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery [PDF]
, 2010 <b>BACKGROUND AND PURPOSE</b> Anandamide and sphingosine-1-phosphate (S1P) both regulate vascular tone in a variety of vessels. This study aimed to examine the mechanisms involved in the regulation of coronary vascular tone by anandamide and ...
Alemany +47 more
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Sphingosine kinase 1 in breast cancer.
Advances in Biological Regulation, 2017 Breast cancer affects 1 out of 8 women in the US and is the second highest cause of death from cancer for women, leading to considerable research examining the causes, progression, and treatment of breast cancer. Over the last two decades, sphingosine-1-phosphate (S1P), a potent sphingolipid metabolite, has been implicated in many processes important ...
K. Geffken, S. Spiegel
semanticscholar +4 more sources
Sphingosine Kinase 1 in Cancer [PDF]
, 2013 The role of sphingolipids as bioactive signaling molecules that can regulate cell fate decisions puts them at center stage for cancer treatment and prevention. While ceramide and sphingosine have been established as antigrowth molecules, sphingosine-1-phosphate (S1P) offers a progrowth message to cells.
Linda A, Heffernan-Stroud, Lina M, Obeid
openaire +2 more sources
Sphingosine kinase and sphingosine-1-phosphate in liver pathobiology [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2017 Over 20 years ago, sphingosine-1-phosphate (S1P) was discovered to be a bioactive signaling molecule. Subsequent studies later identified two related kinases, sphingosine kinase 1 and 2, which are responsible for the phosphorylation of sphingosine to S1P. Many stimuli increase sphingosine kinase activity and S1P production and secretion.
Timothy, Rohrbach +2 more
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Sphingosine Phosphate Lyase Expression Is Essential for Normal Development in Caenorhabditis elegans [PDF]
, 2003 Sphingolipids are ubiquitous membrane constituents whose metabolites function as signaling molecules in eukaryotic cells. Sphingosine 1-phosphate, a key sphingolipid second messenger, regulates proliferation, motility, invasiveness, and programmed cell ...
Fyrst, Henrik +3 more
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Cellular signalling by sphingosine kinase and sphingosine 1‐phosphate [PDF]
IUBMB Life, 2006 AbstractSphingosine kinases, through the formation of the bioactive phospholipid sphingosine 1‐phosphate, have been implicated in a diverse range of cellular processes, including cell proliferation, apoptosis, calcium homeostasis, angiogenesis and vascular maturation. The last few years have seen a number of significant advances in understanding of the
Leclercq, T., Pitson, S.
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Sphingolipids as emerging mediators in retina degeneration [PDF]
, 2019 The sphingolipids ceramide (Cer), sphingosine-1-phosphate (S1P), sphingosine (Sph), and ceramide-1-phosphate (C1P) are key signaling molecules that regulate major cellular functions.
Prado Spalm, Facundo Heber +3 more
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Requirement for sphingosine kinase 1 in mediating phase 1 of the hypotensive response to anandamide in the anaesthetised mouse [PDF]
, 2019 In the isolated rat carotid artery, the endocannabinoid anandamide induces endothelium-dependent relaxation via activation of the enzyme sphingosine kinase (SK).
Alganga, Husam +10 more
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