Results 41 to 50 of about 371,184 (271)
Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease: Review of sphingosine kinase inhibitors [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2013 Sphingosine 1-phosphate (S1P) is an important bioactive sphingolipid metabolite that has been implicated in numerous physiological and cellular processes. Not only does S1P play a structural role in cells by defining the components of the plasma membrane, but in the last 20 years it has been implicated in various significant cell signaling pathways and
K Alexa, Orr Gandy, Lina M, Obeid
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Sphingosine kinase 1 deficiency exacerbates LPS-induced neuroinflammation.
PLoS ONE, 2012 The pathogenesis of inflammation in the central nervous system (CNS), which contributes to numerous neurodegenerative diseases and results in encephalopathy and neuroinflammation, is poorly understood.
Natalia M Grin'kina +5 more
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Saccharomyces cerevisiae as a platform for assessing sphingolipid lipid kinase inhibitors. [PDF]
PLoS ONE, 2018 Successful medicinal chemistry campaigns to discover and optimize sphingosine kinase inhibitors require a robust assay for screening chemical libraries and for determining rank order potencies.
Yugesh Kharel +9 more
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Sphingosine 1-phosphate in renal diseases [PDF]
, 2013 Because of its highly bioactive properties sphingosine 1-phosphate (S1P) is an attractive target for the treatment of several diseases. Since the expression of sphingosine kinases as well as S1P receptors was demonstrated in the kidney, questions about ...
Huwiler, Andrea +2 more
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Identifying novel sphingosine kinase 1 inhibitors as therapeutics against breast cancer
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 Sphingosine kinase 1 (SphK1) is a promising therapeutic target against several diseases including mammary cancer. The aim of present work is to identify a potent lead compound against breast cancer using ligand-based virtual screening, molecular docking,
Faez Iqbal Khan +4 more
semanticscholar +1 more source
Sphingosine kinase and sphingosine 1-phosphate in asthma
Bioscience Reports, 2010 Sphingolipids are amphiphatic molecules ubiquitously expressed in all eukaryotic cell membranes. Initially characterized as structural components of cell membranes, sphingolipids have emerged as sources of important signalling molecules over the past decade.
Wen-Qi, Lai +2 more
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Functional characterization of human sphingosine kinase‐1 [PDF]
FEBS Letters, 2000 Sphingosine kinase catalyzes the phosphorylation of sphingosine to form sphingosine 1‐phosphate (SPP), a novel lipid mediator with both intra‐ and extracellular functions. Based on sequence identity to murine sphingosine kinase (mSPHK1a), we cloned and characterized the first human sphingosine kinase (hSPHK1). The open reading frame of hSPHK1 encodes a
Nava, Victor E. +8 more
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Interaction of microRNAs with sphingosine kinases, sphingosine-1 phosphate, and sphingosine-1 phosphate receptors in cancer [PDF]
Discover Oncology, 2021 AbstractSphingosine-1-phosphate (S1P), a pleiotropic lipid mediator, participates in various cellular processes during tumorigenesis, including cell proliferation, survival, drug resistance, metastasis, and angiogenesis. S1P is formed by two sphingosine kinases (SphKs), SphK1 and SphK2. The intracellularly produced S1P is delivered to the extracellular
Guangmeng Xu +4 more
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Frontiers in Genetics, 2017 Sphingolipid metabolism is important to balance the abundance of bioactive lipid molecules involved in cell signaling, neuronal function, and survival. Specifically, the sphingolipid sphingosine mediates cell death signaling, whereas its phosphorylated ...
Jason P. Chan +6 more
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Feeding Stimulates Sphingosine-1-Phosphate Mobilization in Mouse Hypothalamus. [PDF]
, 2019 Previous studies have shown that the sphingolipid-derived mediator sphingosine-1-phosphate (S1P) reduces food intake by activating G protein-coupled S1P receptor-1 (S1PR1) in the hypothalamus.
Misto, Alessandra +3 more
core +1 more source