Results 51 to 60 of about 371,184 (271)
Sphingosine Kinase 2 Inhibition and Blood Sphingosine 1-Phosphate Levels [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2015 Sphingosine 1-phosphate (S1P) levels are significantly higher in blood and lymph than in tissues. This S1P concentration difference is necessary for proper lymphocyte egress from secondary lymphoid tissue and to maintain endothelial barrier integrity.
Yugesh, Kharel +6 more
openaire +2 more sources
A real-time high-throughput fluorescence assay for sphingosine kinases
Journal of Lipid Research, 2014 Sphingosine kinases (SphKs), of which there are two isoforms, SphK1 and SphK2, have been implicated in regulation of many important cellular processes. We have developed an assay for monitoring SphK1 and SphK2 activity in real time without the need for ...
Santiago Lima +2 more
doaj +1 more source
Sphingosine Kinase-1/sphingosine 1-phosphate pathway in diabetic nephropathy
Chinese Medical Journal, 2014 Objective Diabetic nephropathy (DN) is the major cause of end-stage renal disease worldwide and its prevalence continues to increase. Currently, therapies for DN provide only partial renoprotection; hence new targets for therapeutic intervention need to be identified.
Yanhui, Deng +3 more
openaire +2 more sources
Sphingosine Kinases/Sphingosine 1-Phosphate Signaling in Hepatic Lipid Metabolism [PDF]
Current Pharmacology Reports, 2017 The ever-increasing prevalence of metabolic diseases such as dyslipidemia and diabetes in the western world continues to be of great public health concern. Biologically active sphingolipids, such as sphingosine 1-phosphate (S1P) and ceramide, are important regulators of lipid metabolism.
Eric K. Kwong +3 more
openaire +2 more sources
Frontiers in Molecular Biosciences, 2021 BackgroundTriple-negative breast cancer (TNBC) features a poor prognosis, which is partially attributed to its high metastatic rate. However, there is no effective target for systemic TNBC therapy due to the absence of estrogen, progesterone, and human ...
Weiwei Shi +12 more
doaj +1 more source
Micro-RNA-1 is decreased by hypoxia and contributes to the development of pulmonary vascular remodeling via regulation of sphingosine kinase 1 [PDF]
, 2018 Sphingosine kinase 1 (SphK1) upregulation is associated with pathologic pulmonary vascular remodeling in pulmonary arterial hypertension (PAH), but the mechanisms controlling its expression are undefined.
Chen, Jiwang +6 more
core +1 more source
Cardiovascular Effects of Pharmacological Targeting of Sphingosine Kinase 1
HYPERTENSION, 2019 Supplemental Digital Content is available in the text. High blood pressure is a risk factor for cardiovascular diseases. Ang II (angiotensin II), a key pro-hypertensive hormone, mediates target organ consequences such as endothelial dysfunction and ...
E. Józefczuk +6 more
semanticscholar +1 more source
Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate [PDF]
Biochemical Journal, 2012 S1P (sphingosine 1-phosphate) is a pleiotropic lipid mediator involved in numerous cellular and physiological functions. Of note among these are cell survival and migration, as well as lymphocyte trafficking. S1P, which exerts its effects via five GPCRs (G-protein-coupled receptors) (S1P1–S1P5), is formed by the action of two SphKs (sphingosine kinases)
Yugesh, Kharel +6 more
openaire +2 more sources
The Role of Sphingolipids in the Pathogenesis of Psoriasis
Metabolites, 2022 Psoriasis is a complex, chronic, immunologically mediated disease which involves skin and joints. Psoriasis is commonly connected with numerous other diseases such as liver diseases, metabolic syndrome, impaired glucose tolerance, diabetes mellitus ...
Mateusz Matwiejuk +3 more
doaj +1 more source
Sphingosine kinase 1 promotes liver fibrosis by preventing miR‐19b‐3p‐mediated inhibition of CCR2
Hepatology, 2018 Chronic liver disease mediated by activation of hepatic stellate cells (HSCs) and Kupffer cells (KCs) leads to liver fibrosis. Here, we aimed to investigate the molecular mechanism and define the cell type involved in mediating the sphingosine kinase ...
T. Lan +10 more
semanticscholar +1 more source