Results 61 to 70 of about 371,184 (271)

Plasmodium falciparum ligand binding to erythrocytes induce alterations in deformability essential for invasion [PDF]

, 2017
The most lethal form of malaria in humans is caused by Plasmodium falciparum. These parasites invade erythrocytes, a complex process involving multiple ligand-receptor interactions.
Cowman, Alan, Fleig, Andrea, Horgen, F. David, Malpede, Brian M, Nebl, Thomas, O\u27Neill, Joseph, Rogers, Kelly, Salinas, Nichole D, Sisquella, Xavier, Tham, Wai-Hong, Thompson, Jennifer K, Tolia, Niraj H, Whitehead, Lachlan   +12 more
core   +2 more sources

Exosomes from Human Adipose Tissue-Derived Mesenchymal Stem Cells Promote Epidermal Barrier Repair by Inducing de Novo Synthesis of Ceramides in Atopic Dermatitis. [PDF]

, 2020
Atopic dermatitis (AD) is a multifactorial, heterogeneous disease associated with epidermal barrier disruption and intense systemic inflammation. Previously, we showed that exosomes derived from human adipose tissue-derived mesenchymal stem cells (ASC ...
Cho, Byong Seung, Crumrine, Debra A, Elias, Peter M, Ha, Dae Hyun, Kim, Bogyeong, Kim, Hyun-Keun, Kim, Jin Ock, Kim, Sungeun, Kwon, Hyuck Hoon, Lee, Joon, Lee, Jun Ho, Lee, Yerin, Lim, Jihye, Meyer, Jason M, Park, Gyeong-Hun, Park, Kyungho, Park, Sejeong, Shin, Kyong-Oh, Wakefield, Joan S, Yi, Yong Weon   +19 more
core   +1 more source

SPHK1 (sphingosine kinase 1) induces epithelial-mesenchymal transition by promoting the autophagy-linked lysosomal degradation of CDH1/E-cadherin in hepatoma cells

Autophagy, 2017
SPHK1 (sphingosine kinase 1), a regulator of sphingolipid metabolites, plays a causal role in the development of hepatocellular carcinoma (HCC) through augmenting HCC invasion and metastasis.
Hong Liu, Yan Ma, Hong-wei He, Wu-li Zhao, R. Shao   +4 more
semanticscholar   +1 more source

Sphingosine kinase 1 in murine dorsal root ganglia

AIMS Molecular Science, 2015
The bioactive sphingolipid, sphingosine 1-phosphate (S1P), is a multifunctional mediator that regulates a multitude of processes such as proliferation and differentiation, immune responses, airway constriction and nociception.
Dimitra Beroukas, Maurice Selhorst, Stuart M. Pitson, Dusan Matusica, Ian L. Gibbins, Michaela Kress, Rainer V. Haberberger   +6 more
doaj   +1 more source

The therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease [PDF]

, 2010
The dramatic recent rise in the incidence of allergic or autoimmune inflammatory diseases in the West has been proposed to reflect the lack of appropriate priming of the immune response by infectious agents such as parasitic worms during childhood ...
Al-Riyami, Al-Riyammi, Aoyama, Baev, Bashir, Bogoyevitch, Borghouts, Bowdish, Bowdish, Bradley, Brattig, Burke, Burke, Burke, Busse, Calpe, Choubey, Clutter, Cooper, Couper, Croese, Dagia, Deehan, Diaz, Dittrich, Divangahi, Elliott, Elliott, Elliott, Everts, Fabriek, Falcone, Fulkerson, Goodridge, Goodridge, Goodridge, Goodridge, Goodridge, Gu, Hamerman, Harnett, Harnett, Harnett, Harnett, Harnett, Harnett, Harnett, Harnett, Harnett, He, Houston, Hunter, Ishibashi, Jayapal, Johnson, Kakinuma, Katschke, Kean, Khan, Kim, King, Kitagaki, Kuroki, Lai, Lai, Lamb, Lubberts, Maizels, Mansoor, Marshall, Maurer, McInnes, McInnes, Melendez, Mendoza, Mi, Mori, Moriyama, Moriyama, Moriyama, Nagel-Wolfrum, Node, Page, Polfliet, Pushparaj, Pushparaj, Rajan, Reddy, Rioja, Rogers, Satoh, Saunders, Schnoeller, Schramm, Schramm, Steinfelder, Strickland, Subramanian, Suciu-Foca, Thalhamer, Thomas, Tilstra, van Riet, Wang, Wang, WHO, Wills-Karp, Wilson, Wohlleben, Wong, Wray, Zaccone   +111 more
core   +2 more sources

Sphingosine kinase 1 expression enhances colon tumor growth

Journal of Translational Medicine, 2017
Background Accumulating evidence suggests that sphingosine kinase 1 (SphK1)/sphingosine 1-phosphate pathway plays a pivotal role in colon carcinogenesis.
Hideki Furuya, Yoshiko Shimizu, Paulette M. Tamashiro, Kayoko Iino, Jacek Bielawski, Owen T. M. Chan, Ian Pagano, Toshihiko Kawamori   +7 more
doaj   +1 more source

Characterization of a Bacterial Kinase That Phosphorylates Dihydrosphingosine to Form dhS1P

Microbiology Spectrum, 2022
Like other members of the phylum Bacteroidetes, the oral anaerobe Porphyromonas gingivalis synthesizes a variety of sphingolipids, similar to its human host.
Dev K. Ranjit, Zachary D. Moye, Fernanda G. Rocha, Gregory Ottenberg, Frank C. Nichols, Hey-Min Kim, Alejandro R. Walker, Frank C. Gibson, Mary E. Davey   +8 more
doaj   +1 more source

Bench-to-bedside review: the role of activated protein C in maintaining endothelial tight junction function and its relationship to organ injury. [PDF]

, 2006
Activated protein C (APC) has emerged as a novel therapeutic agent for use in selected patients with severe sepsis, even though the mechanism of its benefit is not well established.
Looney, Mark R, Matthay, Michael A
core   +2 more sources

The Sphingosine Kinase 1/Sphingosine-1-Phosphate Pathway in Pulmonary Arterial Hypertension [PDF]

American Journal of Respiratory and Critical Care Medicine, 2014
Sphingosine kinases (SphKs) 1 and 2 regulate the synthesis of the bioactive sphingolipid sphingosine-1-phosphate (S1P), an important lipid mediator that promotes cell proliferation, migration, and angiogenesis.We aimed to examine whether SphKs and their product, S1P, play a role in the development of pulmonary arterial hypertension (PAH).SphK1 ...
Jiwang, Chen, Haiyang, Tang, Justin R, Sysol, Liliana, Moreno-Vinasco, Krystyna M, Shioura, Tianji, Chen, Irina, Gorshkova, Lichun, Wang, Long Shuang, Huang, Peter V, Usatyuk, Saad, Sammani, Guofei, Zhou, J Usha, Raj, Joe G N, Garcia, Evgeny, Berdyshev, Jason X-J, Yuan, Viswanathan, Natarajan, Roberto F, Machado   +17 more
openaire   +2 more sources

Mebendazole Impedes the Proliferation and Migration of Pancreatic Cancer Cells through SK1 Inhibition Dependent Pathway

Molecules, 2022
Pancreatic ductal adenocarcinoma (PDAC) has one of the highest mortality rates and requires the development of highly efficacious medications that can improve the efficiency of existing treatment methods.
Khem Raj Limbu, Rashmi Bhandari Chhetri, Yoon Sin Oh, Dong Jae Baek, Eun-Young Park   +4 more
doaj   +1 more source