Results 71 to 80 of about 371,184 (271)

Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema [PDF]

, 2010
RATIONALE: Vascular endothelial growth factor receptor (VEGFR) inhibition increases ceramides in lung structural cells of the alveolus, initiating apoptosis and alveolar destruction morphologically resembling emphysema.
Adamowicz, Jeremy J., Berdyshev, Evgeny V., Diab, Khalil J., Garrison, Jana, Gu, Yuan, Hubbard, Walter C., Kamocki, Krzysztof, Petrache, Irina, Rajashekhar, Gangaraju, Rush, Natalia I., Schweitzer, Kelly S., Skobeleva, Anastasia   +11 more
core   +1 more source

Sphingosine kinase 1 in breast cancer: A new molecular marker and a therapy target [PDF]

, 2020
It is now well-established that sphingosine kinase 1 (SK1) plays a significant role in breast cancer development, progression, and spread, whereas SK1 knockdown can reverse these processes.
Alshaker, Heba, Pchejetski, Dmitri, Thrower, Hannah   +2 more
core   +1 more source

Sphingosine 1-Phosphate Receptors and Metabolic Enzymes as Druggable Targets for Brain Diseases

Frontiers in Pharmacology, 2019
The central nervous system is characterized by a high content of sphingolipids and by a high diversity in terms of different structures. Stage- and cell-specific sphingolipid metabolism and expression are crucial for brain development and maintenance ...
Sara Grassi, Laura Mauri, Simona Prioni, Livia Cabitta, Sandro Sonnino, Alessandro Prinetti, Paola Giussani   +6 more
doaj   +1 more source

Dysregulated Choline, Methionine, and Aromatic Amino Acid Metabolism in Patients with Wilson Disease: Exploratory Metabolomic Profiling and Implications for Hepatic and Neurologic Phenotypes. [PDF]

, 2019
Wilson disease (WD) is a genetic copper overload condition characterized by hepatic and neuropsychiatric symptoms with a not well-understood pathogenesis.
Czlonkowska, Anna, Kim, Kyoungmi, Litwin, Tomasz, Mazi, Tagreed A, Medici, Valentina, Sarode, Gaurav V, Shibata, Noreene M   +6 more
core   +2 more sources

Sphingosine 1-Phosphate Receptor 4 Expression in Colorectal Cancer Patients

Walailak Journal of Science and Technology, 2016
The aim of this study was to investigate the expression of S1PR4 in colorectal cancer and its correlation with clinicopathologic characteristics. Paraffin-embedded colorectal cancer samples and matched adjacent normal tissues were collected from 32 ...
Suchittra SAMUHASANEETO, Suthiporn PROMAGSORN, Chuchard PUNSAWAD   +2 more
doaj   +1 more source

Sphingosine-1-phosphate promotes the persistence of activated CD4 T cells in inflamed sites [PDF]

, 2017
Inflammation can be protective or pathogenic depending on context and timeframe. Acute inflammation, including the accumulation of CD4 T cells, accompanies protective immune responses to pathogens, but the presence of activated CD4 T cells at sites of ...
Ammit, Barnden, Brinkmann, Brown, Chimen, Cyster, Debes, Faust, Firestein, Fu, Garrod, Gibson, Han, Hochreiter-Hufford, Hugues, Jo, Karuppuchamy, Kitano, Ledgerwood, Liao, Limaye, Lindquist, Mackay, Mackay, Mammoto, Masopust, Matloubian, Matsuura, McInnes, Means, Mempel, Mendoza, Murphy, Nowarski, Olivera, Priceman, Pyne, Sawicka, Skon, Smith, Spangrude, Tarrason, Teijeira, Tsunemi, Veres, Wang, Wang   +46 more
core   +3 more sources

Design and Development of Novel Urea, Sulfonyltriurea, and Sulfonamide Derivatives as Potential Inhibitors of Sphingosine Kinase 1

Pharmaceuticals, 2020
Sphingosine kinase 1 (SphK1) is one of the well-studied drug targets for cancer and inflammatory diseases. Recently discovered small-molecule inhibitors of SphK1 have been recommended in cancer therapeutics; however, selectivity and potency of first ...
Sonam Roy, Amarjyoti Das Mahapatra, Taj Mohammad, Preeti Gupta, Mohamed F. Alajmi, Afzal Hussain, Md. Tabish Rehman, Bhaskar Datta, Md. Imtaiyaz Hassan   +8 more
doaj   +1 more source

Glucocorticoids for human skin: New aspects of the mechanism of action [PDF]

, 2005
Topical glucocorticoids have always been considered first-line drugs for inflammatory diseases of the skin and bronchial system. Applied systemically, glucocorticoids are used for severe inflammatory and immunological diseases and the inhibition of ...
Ahmed, M., Holtje, H. D., Kleuser, B., Korting, Hans Christian, Schäfer-Korting, Monika   +4 more
core   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

Sphingosine-1-phosphate signaling and the gut-liver axis in liver diseases

Liver Research, 2019
The liver is the central organ involved in lipid metabolism and the gastrointestinal (GI) tract is responsible for nutrient absorption and partitioning. Obesity, dyslipidemia and metabolic disorders are of increasing public health concern worldwide, and ...
Eric K. Kwong, Huiping Zhou
doaj   +1 more source