Results 41 to 50 of about 50,149 (285)

BubR1 is frequently repressed in acute myeloid leukemia and its re-expression sensitizes cells to antimitotic therapy

Haematologica, 2013
Spindle poison-based therapy is of only limited benefit in acute myeloid leukemia while lymphoblastic leukemia/lymphoma responds well. In this study, we demonstrated that the spindle assembly checkpoint protein BubR1 was down-regulated in the vast ...
Dominik Schnerch, Andrea Schmidts, Marie Follo, Josefina Udi, Julia Felthaus, Dietmar Pfeifer, Monika Engelhardt, Ralph Wäsch   +7 more
doaj   +1 more source

The TRAF-interacting protein (TRAIP) is a regulator of the spindle assembly checkpoint [PDF]

Journal of Cell Science, 2014
Accurate chromosome segregation during mitosis is temporally and spatially coordinated by fidelity-monitoring checkpoint systems. Deficiencies in these checkpoint systems can lead to chromosome segregation errors and aneuploidy and promote tumorigenesis.
Chapard Christophe, Meraldi Patrick, Gleich Tobias, Bachmann Daniel, Hohl Daniel, Huber Marcel   +5 more
openaire   +5 more sources

Examining the assembly pathways and active microtubule mechanics underlying spindle self-organization [PDF]

Proc. Natl. Acad. Sci. USA 119, e2209053119 (2022), 2020
The bipolar organization of the microtubule-based mitotic spindle is essential for the faithful segregation of chromosomes in cell division. Despite our extensive knowledge of genes and proteins, the physical mechanism of how the ensemble of microtubules can assemble into a proper bipolar shape remains elusive.
arxiv   +1 more source

CHK1 monitors spindle assembly checkpoint and DNA damage repair during the first cleavage of mouse early embryos

Cell Proliferation, 2020
DNA damage and errors of accurate chromosome segregation lead to aneuploidy and foetal defects. DNA repair and the spindle assembly checkpoint (SAC) are the mechanisms developed to protect from these defects.
Jia-Qian Ju, Xiao-Han Li, Meng-Hao Pan, Yao Xu, Ming-Hong Sun, Yi Xu, Shao‐Chen Sun   +6 more
semanticscholar   +1 more source

Cystathionine β‐synthase is required for oocyte quality by ensuring proper meiotic spindle assembly

Cell Proliferation, Volume 55, Issue 12, December 2022., 2022
CBS is required for oocyte quality by ensuring proper spindle assembly. During oocyte meiotic maturation, CBS ensures spindle assembly by participating in the acetylation of α‐tubulin to stabilize microtubules. Kinetochores remain attached by spindle microtubules. SAC is removed from the kinetochores and then the chromosomes can be separated correctly.
Yan Cao, Xinyu Zhu, Panpan Zhen, Ying Tian, Dengyu Ji, Ke Xue, Wenjing Yan, Jiayin Chai, Huirong Liu, Wen Wang   +9 more
wiley   +1 more source

Attachment and tension in the spindle assembly checkpoint [PDF]

Journal of Cell Science, 2002
Faithful transmission of chromosomes during mitosis is ensured by the spindle assembly checkpoint. This molecular safeguard examines whether prerequisites for chromosome segregation have been satisfied and thereby determines whether to execute or to delay chromosome segregation.
Harish C. Joshi, Joyce Yao, Jun Zhou
openaire   +3 more sources

Spindle assembly checkpoint protein dynamics reveal conserved and unsuspected roles in plant cell division. [PDF]

PLoS ONE, 2009
BACKGROUND: In eukaryotes, the spindle assembly checkpoint (SAC) ensures that chromosomes undergoing mitosis do not segregate until they are properly attached to the microtubules of the spindle.
Marie-Cécile Caillaud, Laetitia Paganelli, Philippe Lecomte, Laurent Deslandes, Michaël Quentin, Yann Pecrix, Manuel Le Bris, Nicolas Marfaing, Pierre Abad, Bruno Favery   +9 more
doaj   +1 more source

Altering microtubule dynamics is synergistically toxic with spindle assembly checkpoint inhibition

Life Science Alliance, 2020
Chromosomal instability (CIN) is a hallmark feature of cancer cells. In this study, Schukken and colleagues screen for compounds that selectively target CIN cells and identify an inhibitor of Src kinase to be selectively toxic for CIN cells.
Klaske M. Schukken, Yu-Chih Lin, P. Bakker, Michael Schubert, Stephanie F Preuss, Judith E. Simon, H. van den Bos, Z. Storchová, M. Colomé-Tatché, H. Bastians, D. Spierings, F. Foijer   +11 more
semanticscholar   +1 more source

Toward a systems-level view of mitotic checkpoints [PDF]

Prog Biophys Mol Biol. 2015 Mar;117(2-3):217-24, 2016
Reproduction and natural selection are the key elements of life. In order to reproduce, the genetic material must be doubled, separated and placed into two new daughter cells, each containing a complete set of chromosomes and organelles. In mitosis, transition from one process to the next is guided by intricate surveillance mechanisms, known as the ...
arxiv   +1 more source

Recent advances in understanding the role of Cdk1 in the Spindle Assembly Checkpoint

F1000Research, 2020
The goal of mitosis is to form two daughter cells each containing one copy of each mother cell chromosome, replicated in the previous S phase. To achieve this, sister chromatids held together back-to-back at their primary constriction, the centromere ...
Angela Flavia Serpico, D. Grieco
semanticscholar   +1 more source