Results 1 to 10 of about 407 (68)
Overlap microtubules link sister k-fibres and balance the forces on bi-oriented kinetochores
Nature Communications, 2016 During metaphase, k-fibre microtubules exert force on kinetochores, but there are also non-kinetochore microtubules close to kinetochores without a known function.
Maja Novak +2 more
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Effects of malleable kinetochore morphology on measurements of intrakinetochore tension [PDF]
Open Biology, 2020 The distance between fluorescent spots formed by various kinetochore proteins (delta) is commonly interpreted as a manifestation of intrakinetochore tension (IKT) caused by microtubule-mediated forces.
Fioranna Renda +6 more
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Cells, 2023 Nucleolar and Spindle-Associated Protein 1 (NuSAP1) is an important mitotic regulator, implicated in control of mitotic microtubule stability and chromosome segregation. NuSAP1 regulates these processes by interacting with several protein partners.
Michela Damizia +3 more
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Bub1 kinase in the regulation of mitosis
Animal Cells and Systems, 2021 Accurate chromosome segregation is required for cell survival and organismal development. During mitosis, the spindle assembly checkpoint acts as a safeguard to maintain the high fidelity of mitotic chromosome segregation by monitoring the attachment of ...
Taekyung Kim, Anton Gartner
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Evolutionary cell biology of chromosome segregation: insights from trypanosomes [PDF]
Open Biology, 2013 Faithful transmission of genetic material is essential for the survival of all organisms. Eukaryotic chromosome segregation is driven by the kinetochore that assembles onto centromeric DNA to capture spindle microtubules and govern the movement of ...
Bungo Akiyoshi, Keith Gull
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Structural basis of Stu2 recruitment to yeast kinetochores
eLife, 2021 Chromosome segregation during cell division requires engagement of kinetochores of sister chromatids with microtubules emanating from opposite poles. As the corresponding microtubules shorten, these ‘bioriented’ sister kinetochores experience tension ...
Jacob A Zahm +4 more
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chTOG is a conserved mitotic error correction factor
eLife, 2020 Accurate chromosome segregation requires kinetochores on duplicated chromatids to biorient by attaching to dynamic microtubules from opposite spindle poles, which exerts forces to bring kinetochores under tension.
Jacob A Herman +2 more
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Roles for the conserved spc105p/kre28p complex in kinetochore-microtubule binding and the spindle assembly checkpoint. [PDF]
PLoS ONE, 2009 BackgroundKinetochores attach sister chromatids to microtubules of the mitotic spindle and orchestrate chromosome disjunction at anaphase. Although S. cerevisiae has the simplest known kinetochores, they nonetheless contain approximately 70 subunits that
Cinzia Pagliuca +4 more
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Phosphatases in Mitosis: Roles and Regulation
Biomolecules, 2019 Mitosis requires extensive rearrangement of cellular architecture and of subcellular structures so that replicated chromosomes can bind correctly to spindle microtubules and segregate towards opposite poles.
Margarida Moura, Carlos Conde
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Biology Open, 2016 The first meiotic division in human oocytes is highly error-prone and contributes to the uniquely high incidence of aneuploidy observed in human pregnancies.
Jessica Patel +3 more
doaj +1 more source