Results 1 to 10 of about 19 (19)
European Journal of Organic Chemistry, Volume 26, Issue 41, November 2, 2023., 2023 Is it possible to build up molecular complexity without the help of a catalyst? Yes, it is! With the suitable starting‐materials, a domino or multicomponent reaction can be initiated just turning on the right light. Abstract Achieving high molecular complexity can be not trivial, but the exploitation of domino reactions provides an atom‐ and step ...
Polyssena Renzi +3 more
wiley +1 more source
Angewandte Chemie, Volume 135, Issue 34, August 21, 2023., 2023 Durch eine goldkatalysierte Cycloadditionsreaktion von Alkinen mit von Isatin abgeleiteten Ketiminen wurde ein neuartiges Protokoll zur Synthese von Spirooxindolen entwickelt, die eine hervorragende antiproliferative Aktivität auf menschliche Tumorzelllinien besitzen.
Yaowen Liu +11 more
wiley +1 more source
Angewandte Chemie International Edition, Volume 62, Issue 34, August 21, 2023., 2023 A novel protocol for the synthesis of spirooxindoles that possess excellent antiproliferative activity on human tumor cell lines was achieved through a gold‐catalyzed cycloaddition reaction of alkynes with isatin‐derived ketimines. Various functionalized and readily available alkynes reacted under mild reaction conditions. Abstract Due to its excellent
Yaowen Liu +11 more
wiley +1 more source
Mechanochemical Activation of NaHCO3: A Solid CO2 Surrogate in Carboxylation Reactions
ChemSusChem, EarlyView.This study presents sodium bicarbonate (NaHCO3) as a safe, solid source of CO2 for mechanochemical carboxylation reactions. Mechanochemical methods for synthesizing cyclic carbamates and organic carbonates from NaHCO3 are developed. This approach holds significant potential for pharmaceutical applications, highlighting solvent‐minimized synthesis and ...
Francesco Mele +11 more
wiley +1 more source
ChemistrySelect, Volume 10, Issue 17, May 5, 2025.A new set of spirooxindole‐ and spiroindenoquinoxaline‐derived pyrrolo[3,4‐c] pyrroles has been synthesized through atom‐economic one‐pot multicomponent reactions. Based on the results, compounds 4b and 5a demonstrated promising Glide scores and exhibited strong binding affinity with decaprenylphosphoryl‐β‐D‐ribofuranose oxidoreductase.
Mathiyazhagan Lavanya +8 more
wiley +1 more source
Chemistry – An Asian Journal, Volume 20, Issue 8, April 17, 2025.In this review, the advancements in the cyclization of 1,3‐enynes to construct structurally diverse heterocyclic and carbocyclic frameworks are portrayed comprehensively. Divergent cyclization protocols along with mechanistic aspects for key transformations are also detailed. Abstract 1,3‐Enynes have demonstrated their utility as valuable precursors to
Akash P. Sakla +4 more
wiley +1 more source
Cooperative Vinylogous Enamine and Metal Catalysis
ChemCatChem, Volume 17, Issue 7, April 4, 2025.This review describes transformations combining vinylogous enamine catalysis with transition metal or Lewis acid catalysis that have emerged since the seminal report of dienamine catalysis in 2006. These transformations span numerous reaction classes, including alkylation, allylation, propargylation, oxyamination, dimerization, as well as cascade ...
Stacey E. Brenner‐Moyer
wiley +1 more source
Microwave‐Assisted Multicomponent Synthesis of Spirooxindole Dihydropyridine Bisphosphonates
European Journal of Organic Chemistry, Volume 28, Issue 6, February 10, 2025.A new, simple, catalyst‐ and solvent‐free microwave‐assisted multicomponent method was developed for the synthesis of spirooxindole dihydropyridine bisphosphonates as a new family of compounds by the one‐pot reaction of isatins, β‐ketophosphonates and primary amines.
Bettina Rávai +3 more
wiley +1 more source
Advanced Synthesis &Catalysis, Volume 366, Issue 24, Page 5008-5014, December 17, 2024.Abstract In this work, we present an organocatalytic spiroannulation method that provides access to spirocyclic benzofuran‐2‐ones. The reaction proceeds via the generation of an azolium dienolate from an α‐bromo‐α,β‐unsaturated aldehyde using a chiral N‐heterocyclic carbene, followed by annulation with benzofuran‐2‐one‐derived alkenes.
Ladislav Lóška +8 more
wiley +1 more source
European Journal of Organic Chemistry, Volume 27, Issue 41, November 4, 2024.A diaminomethylenemalononitrile organocatalyst promoted asymmetric cascade Michael/Michael reactions between a 2‐(trifluoromethylmethylene)indane‐1,3‐dione derivative and α‐alkylidene succinimides, resulting in spiroindane‐1,3‐dione derivatives.
Ryo Tsuyusaki +4 more
wiley +1 more source