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Complete transfer of chirality in an intramolecular, thermal [2 + 2] cycloaddition of allene-ynes to form non-racemic spirooxindoles

Beilstein Journal of Organic Chemistry, 2011
A thermal [2 + 2] cycloaddition reaction of allene-ynes has been used to transform chiral non-racemic allenyl oxindoles into chiral non-racemic spirooxindoles containing an alkylidene cyclobutene moiety.
Kay M. Brummond, Joshua M. Osbourn
doaj +1 more source

Quantitative Structure-Activity Relationship and Adme Prediction Studies on Series of Spirooxindoles Derivatives for Anti-Cancer Activity Against Colon Cancer Cell Line Hct-116

, 2023
Sukhmeet Kaur +4 more
openalex +1 more source

New spirooxindole-thiazolidine derivatives as antiseizure agents: Biological evaluation and computational studies

Results in Chemistry
Background: Oxindoles and spirooxindoles are considered privileged scaffolds in medicinal chemistry due to their diverse biological activities, which include anticonvulsant, anticancer, and antimicrobial properties.
Leila Emami +9 more
doaj +1 more source

A Sequential Nitro-Michael Addition and Reductive Cyclization Cascade Reaction for Diastereoselective Synthesis of Multifunc-tionalized 3,3'-pyrrolidinyl-spirooxindoles [PDF]