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Heterogeneous organocatalysis: the proline case. [PDF]
de Carvalho GSG +3 more
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Dynamic radical recombination enabling stereodivergent construction of spirocycles with nonadjacent stereocenters. [PDF]
Sun Z +12 more
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Eco-friendly K-10 Clay-Mediated [3 + 3] Spiroannulation of Morita-Baylis-Hillman Adduct of Isatin with Anthracene: Synthesis of Green Fluorophore Compounds. [PDF]
Vaithiyanathan V, Sivaraman S.
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Enantioselective Construction of Spirooxindole-Fused Cyclopentanes
The Journal of Organic Chemistry, 2021The present study reports an asymmetric organocatalytic cascade reaction of oxindole derivates with α,β-unsaturated aldehydes efficiently catalyzed by simple chiral secondary amine. Spirooxindole-fused cyclopentanes were produced in excellent isolated yields (up to 98%) with excellent enantiopurities (up to 99% ee) and moderate to high ...
Vojtěch Dočekal +7 more
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Organic Letters, 2000
[reaction: see text]Reaction of indole amides 5 with tributylstannane gave spiroindolenines 9 which are readily converted into spiropyrrolidinyloxindoles. This tricyclic system is found in a number of interesting natural products.
S T, Hilton +3 more
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[reaction: see text]Reaction of indole amides 5 with tributylstannane gave spiroindolenines 9 which are readily converted into spiropyrrolidinyloxindoles. This tricyclic system is found in a number of interesting natural products.
S T, Hilton +3 more
openaire +2 more sources
Spirooxindoles as Potential Pharmacophores
Mini-Reviews in Medicinal Chemistry, 2017The spiroindole heterocyclic scaffold is found in many natural products and has been identified as an important bioactive agent. Over the past few decades, various spiroindole-containing compounds have been reported to possess biological properties and hence found in the structure of many synthetic pharmaceuticals.
Siva S, Panda +3 more
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