Results 161 to 170 of about 3,654 (228)

3,3-Bis(hydroxyaryl)oxindoles and Spirooxindoles Bearing a Xanthene Moiety: Synthesis, Mechanism, and Biological Activity

Dániel Steinsits, Bettina Rávai, Zsolt Kelemen, László Hackler, Viktor Vernyik, László G. Puskás, Erika Bálint   +6 more
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Dinuclear Zn-Catalytic System as Brønsted Base and Lewis Acid for Enantioselectivity in Same Chiral Environment. [PDF]

ACS Omega
Ayesha, Ashraf A, Arshad M, Sajid N, Rasool N, Abbas M, Nazeer U, Khalid M, Imran M.   +8 more
europepmc   +1 more source

Synthesis, DFT calculation, and molecular docking simulation of spirooxindoles based Creatinine chemosensor of Cu2+

Ghodsi Mohammadi Ziarani, Nikoo Shamkhali, Zahra Panahande, Mehran Feizi‐Dehnayebi, Alireza Badiei   +4 more
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In situ generated CF₃CHN₂ with 3-ylideneoxindoles to access CF₃-containing pyrazolo[1,5-c]quinazolines derivatives. [PDF]

RSC Adv
Hu MC, Zhou HT, Fang YC, Zhang LR, Cui BD, Chen YZ, Bai M.   +6 more
europepmc   +1 more source

Novel spirooxindole compounds as anticancer agents: targeting Plk4 kinase through design, synthesis, and molecular docking

Mervat S. Sammor, Almeqdad Y. Habashneh, Mahmoud A. Al-Sha’er, Sanaa K. Bardaweel, Mustafa M. El‐Abadelah   +4 more
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Exploiting spirooxindoles for dual DNA targeting/CDK2 inhibition and simultaneous mitigation of oxidative stress towards selective NSCLC therapy; synthesis, evaluation, and molecular modelling studies. [PDF]

RSC Med Chem
Islam MS, Al-Jassas RM, Al-Majid AM, Haukka M, Nafie MS, Abu-Serie MM, Teleb M, El-Yazbi A, Alayyaf AMA, Barakat A, Shaaban MM.   +10 more
europepmc   +1 more source

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An Access to Highly Functionalized Dihydrobenzofuran Spirooxindole Scaffolds.

Organic Letters, 2022
We have developed an efficient protocol for the construction of polycyclic dihydrobenzofuran spirooxindole scaffolds via base promoted cascade annulation of Morita-Baylis-Hillman (MBH) carbonates of isatins with ortho-hydroxychalcones or ortho-hydroxy-β ...
Daqian Wang, Jing Sun, Ying Han, Qiu Sun, Chaoguo Yan   +4 more
semanticscholar   +3 more sources

Enantioselective Construction of Spirooxindole-Fused Cyclopentanes [PDF]

The Journal of Organic Chemistry, 2021
The present study reports an asymmetric organocatalytic cascade reaction of oxindole derivates with α,β-unsaturated aldehydes efficiently catalyzed by simple chiral secondary amine. Spirooxindole-fused cyclopentanes were produced in excellent isolated yields (up to 98%) with excellent enantiopurities (up to 99% ee) and moderate to high ...
Vojtěch Dočekal, Andrea Vopálenská, Pavel Měrka, Klára Konečná, Ondřej Jand’ourek, Milan Pour, Ivana Císařová, Jan Veselý   +7 more
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Asymmetric Synthesis of Multicyclic Spirooxindole Derivatives Bearing Stereogenic Quaternary Carbon Atoms.

Organic Letters, 2023
An organocatalyzed stereoselective domino reaction as a facile approach to multicyclic spirooxindole derivatives bearing two stereogenic quaternary carbon atoms is reported. The alkyl-substituted chiral thiourea catalyst was efficient for the reaction to
Xiaoyi Li, Zihao Li, Rong Zhang, Zhen-hus Zhou, Yonghui Zhang, Yi Xia, W. Yao, Zhen Wang   +7 more
semanticscholar   +1 more source

Recent Strategies in the Synthesis of Spiroindole and Spirooxindole Scaffolds

Topics in Current Chemistry, 2021
Spiroindole and spirooxindole scaffolds are very important spiro-heterocyclic compounds in drug design processes. Significant attention has been directed at obtaining molecules based on spiroindole and spirooxindole derivatives that have bioactivity against cancer cells, microbes, and different types of disease affecting the human body.
Shima Nasri, M. Bayat, Faezeh Mirzaei
semanticscholar   +4 more sources