Results 11 to 20 of about 727 (157)

Catalytic Asymmetric Synthesis of gem‐Dicyano‐Spirocyclopropyl Oxindoles by N‐9‐Anth‐PyBidine‐Co(OAc)2: Advantage of Three‐Component Coupling Approach

ChemistryEurope
A chiral N‐9‐Anth‐PyBidine‐Co(OAc)2 complex catalyzed the kinetically controlled asymmetric Michael/alkylation reaction of 3‐chlorooxindoles with alkylidenemalononitriles to give gem‐dicyano‐spirocyclopropyl oxindoles in a highly diastereo‐ and ...
Takaaki Saito, Ren Miyasaka, Kazumasa Kon, Yuri Takagi, Takayoshi Arai   +4 more
doaj   +2 more sources

Structural basis of the stereoselective formation of the spirooxindole ring in the biosynthesis of citrinadins

Nature Communications, 2021
Prenylated indole alkaloids contain spirooxindole rings with a 3R or 3S carbon stereocenter, which determines their bioactivities, but the biocatalytic mechanism controlling the 3R- or 3S-spirooxindole formation was unclear.
Zhiwen Liu, Fanglong Zhao, Boyang Zhao, Jie Yang, Joseph Ferrara, Banumathi Sankaran, B. V. Venkataram Prasad, Biki Bapi Kundu, George N. Phillips, Yang Gao, Liya Hu, Tong Zhu, Xue Gao   +12 more
doaj   +1 more source

Natural-Product-Inspired Microwave-Assisted Synthesis of Novel Spirooxindoles as Antileishmanial Agents: Synthesis, Stereochemical Assignment, Bioevaluation, SAR, and Molecular Docking Studies

Molecules, 2023
Leishmaniasis is a neglected tropical disease, and there is an emerging need for the development of effective drugs to treat it. To identify novel compounds with antileishmanial properties, a novel series of functionalized spiro[indoline-3,2′-pyrrolidin]-
Nawal Kishore Sahu, Ritu Sharma, Kshirsagar Prasad Suhas, Jyoti Joshi, Kunal Prakash, Richa Sharma, Ramendra Pratap, Xiwen Hu, Sukhbir Kaur, Mukesh Jain, Carmine Coluccini, Paolo Coghi, Sandeep Chaudhary   +12 more
doaj   +1 more source

Exploring Regio- and Stereoselectivity in [3+2] Cycloaddition: Molecular Electron Density Theory Approach for Novel Spirooxindole-Based Benzimidazole with Pyridine Spacer

Crystals, 2023
A new ethylene derivative was synthesized as a precursor for the [3+2] cycloaddition (32CA) reaction to access a novel spirooxindole embodied with benzimidazole with a pyridine spacer.
Saeed Alshahrani, Abdullah Mohammed Al-Majid, Abdullah Saleh Alamary, Mar Ríos-Gutiérrez, Assem Barakat   +4 more
doaj   +1 more source

Transition metal-catalyzed synthesis of spirooxindoles

RSC Advances, 2021
Spirooxindoles are used as anticancer-, antiviral-, antimicrobial agents etc. The use of transition metals as catalysts for the synthesis of spirooxindoles is advancing rapidly. Here, we focus on recent advances in transition metal-catalyzed synthesis of spirooxindoles.
P. V. Saranya, Mohan Neetha, Thaipparambil Aneeja, Gopinathan Anilkumar   +3 more
openaire   +3 more sources

Antitumor properties of certain spirooxindoles towards hepatocellular carcinoma endowed with antioxidant activity

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
In the current medical era, spirooxindole motif stands out as a privileged heterospirocyclic scaffold that represents the core for a wide range of bioactive naturally isolated products (such as Strychnofoline and spirotryprostatins A and B) and synthetic
Sara T. Al-Rashood, Ahmed R. Hamed, Ghada S. Hassan, Hamad M. Alkahtani, Abdulrahman A. Almehizia, Amal Alharbi, Mohammad M. Al-Sanea, Wagdy M. Eldehna   +7 more
doaj   +1 more source

[Bmim]Br Accelerated One-Pot Three-Component Cascade Protocol for the Construction of Spirooxindole–Pyrrolidine Heterocyclic Hybrids

Molecules, 2020
Our synthetic approach for the assembly of structurally complex spirooxindole heterocyclic hybrids was based on an ionic liquid, [bmim]Br mediated one-pot three-component cascade reaction strategy involving 1,3-dipolar cycloaddition reaction of N-1-(2 ...
Raju Suresh Kumar, Dhaifallah M. Al-thamili, Abdulrahman I. Almansour, Natarajan Arumugam, Necmi Dege   +4 more
doaj   +1 more source

Tri(n-butyl)phosphine-promoted domino reaction for the efficient construction of spiro[cyclohexane-1,3'-indolines] and spiro[indoline-3,2'-furan-3',3''-indolines]

Beilstein Journal of Organic Chemistry, 2022
The tri(n-butyl)phosphine-catalyzed reaction of isatylidene malononitriles and bis-chalcones in chloroform at 65 °C afforded functionalized spiro[cyclohexane-1,3'-indolines] in good yields and with good diastereoselectivity.
Hui Zheng, Ying Han, Jing Sun, Chao-Guo Yan   +3 more
doaj   +1 more source

Drug Repurposing of Lactoferrin Combination in a Nanodrug Delivery System to Combat Severe Acute Respiratory Syndrome Coronavirus-2 Infection

Dr. Sulaiman Al Habib Medical Journal, 2021
A drug repurposing approach for Food and Drug Administration (FDA)-approved drugs and preclinical entity by using cheminformatics and chemical transformational method, with the objective of discovering safer novel potent inhibitors that are selective for
Assem Barakat, Abdullah Mohammed Al-Majid, Gehad Lotfy, Mohamed Ali, Ahmed Mostafa, Yaseen A.M.M. Elshaier   +5 more
doaj   +1 more source

From data to discovery: leveraging big data in plant natural products biosynthesis research. [PDF]

Plant J
SUMMARY Plant natural products or specialized metabolites play a vital role in drug discovery and development, with many clinically important derivatives such as the anticancer drugs topotecan (derived from the natural alkaloid camptothecin) and etoposide (derived from the natural polyphenol podophyllotoxin).
McConnachie M, Nguyen TM, Kim T, Nguyen TD, Dang TT.   +4 more
europepmc   +2 more sources