Natural-Product-Inspired Microwave-Assisted Synthesis of Novel Spirooxindoles as Antileishmanial Agents: Synthesis, Stereochemical Assignment, Bioevaluation, SAR, and Molecular Docking Studies [PDF]
Molecules, 2023 Leishmaniasis is a neglected tropical disease, and there is an emerging need for the development of effective drugs to treat it. To identify novel compounds with antileishmanial properties, a novel series of functionalized spiro[indoline-3,2′-pyrrolidin]-
Nawal Kishore Sahu +12 more
doaj +2 more sources
Design, Synthesis, Chemical and Biochemical Insights Into Novel Hybrid Spirooxindole-Based p53-MDM2 Inhibitors With Potential Bcl2 Signaling Attenuation [PDF]
Frontiers in Chemistry, 2021 The tumor resistance to p53 activators posed a clinical challenge. Combination studies disclosed that concomitant administration of Bcl2 inhibitors can sensitize the tumor cells and induce apoptosis.
Abu-Serie, Marwa M. +11 more
core +3 more sources
Spirooxindole derivative SOID-8 induces apoptosis associated with inhibition of JAK2/STAT3 signaling in melanoma cells. [PDF]
PLoS ONE, 2012 Melanoma is generally refractory to current chemotherapy, thus new treatment strategies are needed. In this study, we synthesized a series of spirooxindole derivatives (SOID-1 to SOID-12) and evaluated their antitumor effects on melanoma.
Yan Tian +10 more
doaj +3 more sources
Nanoformulation of Spirooxindole and Methods for Treating Hepatocellular Carcinoma
PharmaceuticsObjectives: This in vivo study introduces a newly developed spirooxindole derivative that is deemed safe and effective as a potential targeted therapy for various cancers.
Assem Barakat +6 more
doaj +2 more sources
Activation of p53 signaling and regression of breast and prostate carcinoma cells by spirooxindole-benzimidazole small molecules [PDF]
Frontiers in PharmacologyThis study discusses the synthesis and use of a new library of spirooxindole-benzimidazole compounds as inhibitors of the signal transducer and activator of p53, a protein involved in regulating cell growth and cancer prevention.
Assem Barakat +8 more
doaj +2 more sources
The Therapeutic Potential of Spirooxindoles in Cancer: A Focus on p53–MDM2 Modulation
PharmaceuticalsThe p53, often referred to as the “guardian of the genome”, is a well-established tumor-suppressor protein that plays a critical role in regulating the cell cycle, DNA repair, differentiation, and apoptosis, with its activity primarily modulated by the ...
Adel S. Girgis +8 more
doaj +2 more sources
Recent Advances in Green Approaches for Synthesis of Oxindole Derivatives [PDF]
, 2023 Oxindole derivatives are nitrogen-containing, five-membered heterocyclic molecules found in both natural and synthetic substances with diverse biological functions.
D.M.T.A.Samaradiwakara +2 more
core +2 more sources
Discovery of a cytochrome P450 enzyme catalyzing the formation of spirooxindole alkaloid scaffold
Frontiers in Plant Science, 2023 Spirooxindole alkaloids feature a unique scaffold of an oxindole ring sharing an atom with a heterocyclic moiety. These compounds display an extensive range of biological activities such as anticancer, antibiotics, and anti-hypertension.
Tuan-Anh M. Nguyen +5 more
doaj +1 more source
Asymmetric Organocatalytic Synthesis of aza-Spirocyclic Compounds from Isothiocyanates and Isocyanides [PDF]
, 2021 The spirocyclic motif is present in natural products, chiral ligands, and compounds of pharmacological interest. Isothiocyanates as well as isocyanides bearing electron-withdrawing groups in the α-position can be deprotonated and react as formal dipoles ...
Blay Llinares, Gonzalo +4 more
core +1 more source
Molecules, 2021 A new series of di-spirooxindole analogs, engrafted with oxindole and cyclohexanone moieties, were synthesized. Initially, azomethine ylides were generated via reaction of the substituted isatins 3a–f (isatin, 3a, 6-chloroisatin, 3b, 5-fluoroisatin, 3c ...
Abdullah Mohammed Al-Majid +7 more
doaj +1 more source