Results 21 to 30 of about 2,755 (155)
Synthesis and Diversification of Chiral Spirooxindoles via Organocatalytic Cascade Reactions
Chemistry Proceedings, 2023 The synthesis of chiral spirooxindoles through different amino catalytic activation modes is described herein. Several alkenylisatins were obtained from the Knoevenagel reaction of isatin and activated methylene derivatives containing electron ...
Jessica Navarro Vega +2 more
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Engaging Isatins in Multicomponent Reactions (MCRs) – Easy Access to Structural Diversity [PDF]
, 2021 Multicomponent reactions (MCRs) are a valuable tool in diversity-oriented synthesis. Its application to privileged structures is gaining relevance in the fields of organic and medicinal chemistry.
Brandão, Pedro +4 more
core +1 more source
Nature Communications, 2021 Prenylated indole alkaloids contain spirooxindole rings with a 3R or 3S carbon stereocenter, which determines their bioactivities, but the biocatalytic mechanism controlling the 3R- or 3S-spirooxindole formation was unclear.
Zhiwen Liu +12 more
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Spirooxindole: A Versatile Biologically Active Heterocyclic Scaffold
Molecules, 2023 Spirooxindoles occupy an important place in heterocyclic chemistry. Many natural spirooxindole-containing compounds have been identified as bio-promising agents. Synthetic analogs have also been synthesized utilizing different pathways.
Siva S. Panda +3 more
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Synthesis of Functionalized Spirooxindole Polycycles: Use of Cyclic 1,3-Diones as Reactants or as Condition-Tuning Molecules [PDF]
, 2023 This account describes the strategies for the synthesis of functionalized spirooxindole polycycles, including enantiomerically enriched forms, that we have developed and reported.
Sohail Muhammad, Tanaka Fujie
core +1 more source
Studies on the Enantioselective Synthesis of E-Ethylidene-bearing Spiro[indolizidine-1,3′-oxindole] Alkaloids [PDF]
, 2021 A synthetic route for the enantioselective construction of the tetracyclic spiro[indolizidine-1,3'-oxindole] framework present in a large number of oxindole alkaloids, with a cis H-3/H-15 stereochemistry, a functionalized two-carbon substituent at C-15 ...
Amat Tusón, Mercedes +4 more
core +1 more source
Crystals, 2023 A new ethylene derivative was synthesized as a precursor for the [3+2] cycloaddition (32CA) reaction to access a novel spirooxindole embodied with benzimidazole with a pyridine spacer.
Saeed Alshahrani +4 more
doaj +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 In the current medical era, spirooxindole motif stands out as a privileged heterospirocyclic scaffold that represents the core for a wide range of bioactive naturally isolated products (such as Strychnofoline and spirotryprostatins A and B) and synthetic
Sara T. Al-Rashood +7 more
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Molecules, 2020 Our synthetic approach for the assembly of structurally complex spirooxindole heterocyclic hybrids was based on an ionic liquid, [bmim]Br mediated one-pot three-component cascade reaction strategy involving 1,3-dipolar cycloaddition reaction of N-1-(2 ...
Raju Suresh Kumar +4 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2022 The tri(n-butyl)phosphine-catalyzed reaction of isatylidene malononitriles and bis-chalcones in chloroform at 65 °C afforded functionalized spiro[cyclohexane-1,3'-indolines] in good yields and with good diastereoselectivity.
Hui Zheng +3 more
doaj +1 more source