Results 21 to 30 of about 3,654 (228)

Recent advances in the halogenated spirooxindoles as novel anticancer scaffolds: chemistry and bioactivity approach. [PDF]

RSC Adv
Nafie MS, Shawish I, Fahmy SA, Diab MK, Abdelfattah MM, Hassen BM, Darwish KM, El-Faham A, Barakat A.   +8 more
europepmc   +2 more sources

Corrigendum: Discovery of spirooxindole-derived small-molecule compounds as novel HDAC/MDM2 dual inhibitors and investigation of their anticancer activity [PDF]

Frontiers in Oncology, 2023
Qian Zhao, Shan-Shan Xiong, Can Chen, Can Chen, Hong-Ping Zhu, Hong-Ping Zhu, Xin Xie, Cheng Peng, Gu He, Bo Han   +9 more
doaj   +2 more sources

Potent EGFR/PARP-1 inhibition by spirooxindole-triazole hybrids for targeted liver cancer therapy. [PDF]

RSC Adv
Nafie MS, Ali M, Alwehaibi MA, Alayyaf AA, Al-Muhanna MK, Almuqati NS, Alghamdi AA, Haukka M, Tariq SS, Ul-Haq Z, Barakat A.   +10 more
europepmc   +2 more sources

Utilizing MEDT analysis of [3 + 2] cycloaddition reaction: x-ray crystallography of spirooxindole linked with thiophene/furan heterocycles and triazole framework. [PDF]

BMC Chem
Alayyaf AA, Ali M, Alwehaibi MA, Al-Muhanna MK, Soliman SM, Ríos-Gutiérrez M, Haukka M, Barakat A.   +7 more
europepmc   +2 more sources

B(iii)-catalyzed synthesis of spirooxindole and dihydro-2-oxopyrrole under solventless conditions in a ball mill, along with DFT computations. [PDF]

RSC Adv
Mallah D, Mirjalili BBF, Basharnavaz H, Bamoniri A.   +3 more
europepmc   +2 more sources

Construction of Spirooxindole Skeleton Through Intramolecular Dieckmann Cyclization [PDF]

Natural Products and Bioprospecting, 2017
A highly efficient and direct approach was developed to construct the structurally diverse spirooxindole skeleton, which is an important basic motif in natural products.
Ting Wu, Zhiqiang Pan, Chengfeng Xia
doaj   +4 more sources

Stereoselective Synthesis of the Di-Spirooxindole Analogs Based Oxindole and Cyclohexanone Moieties as Potential Anticancer Agents

Molecules, 2021
A new series of di-spirooxindole analogs, engrafted with oxindole and cyclohexanone moieties, were synthesized. Initially, azomethine ylides were generated via reaction of the substituted isatins 3a–f (isatin, 3a, 6-chloroisatin, 3b, 5-fluoroisatin, 3c ...
Abdullah Mohammed Al-Majid, M. Ali, Mohammad Shahidul Islam, Saeed Alshahrani, Abdullah Saleh Alamary, Sammer Yousuf, M. Iqbal Choudhary, Assem Barakat   +7 more
doaj   +1 more source

New spirooxindole-thiazolidine derivatives as antiseizure agents: Biological evaluation and computational studies

Results in Chemistry
Background: Oxindoles and spirooxindoles are considered privileged scaffolds in medicinal chemistry due to their diverse biological activities, which include anticonvulsant, anticancer, and antimicrobial properties.
Leila Emami, Leila Moezi, Pegah Mardaneh, Sara Sadeghian, Elaheh Ataollahi, Masoumeh Divar, Sahar Zarei, Saeed Agah, Razieh Sabet, Soghra Khabnadideh   +9 more
doaj   +2 more sources

Synthesis and Diversification of Chiral Spirooxindoles via Organocatalytic Cascade Reactions

Chemistry Proceedings, 2023
The synthesis of chiral spirooxindoles through different amino catalytic activation modes is described herein. Several alkenylisatins were obtained from the Knoevenagel reaction of isatin and activated methylene derivatives containing electron ...
Jessica Navarro Vega, David Cruz Cruz, Clarisa Villegas Gómez   +2 more
doaj   +1 more source

The Synthesis of 3-Spirooxindole Derivatives. IV. The Conversion of 3-Spirooxindole to Indole Derivative.

Chemical and Pharmaceutical Bulletin, 1963
The conversion of 1-methylspiro (indoline-3, 1'-indolizine)-2-one to 12-methyl-1, 2, 3, 4, 6, 7, 12, 12b-octahydroindolo [2, 3-a] quinolizine is described as a preliminary for the chemical correlation of N-methylrhynchophyllane with N-methyldihydrocorynantheane.
Takeshi Oishi, Shizuo Maeno, Yoshio Ban
openalex   +5 more sources