Results 21 to 30 of about 727 (157)
Beilstein Journal of Organic Chemistry, 2023 A straightforward synthetic protocol for the efficient construction of diazepine-containing spiroindolines has been developed and proceeds through a by base-promoted annulation reaction of α-halogenated N-acylhydrazones and isatin-derived MBH carbonates.
Xing Liu +3 more
doaj +1 more source
Crystals, 2021 A new spirooxindole hybrid engrafted imidazo[2,1-b]thiazole core structure was designed and achieved via [3+2] cycloaddition reaction approach. One multi-component reaction between the ethylene derivative based imidazo[2,1-b]thiazole scaffold with 6-Cl ...
Mezna Saleh Altowyan +5 more
doaj +1 more source
Molecules, 2017 This article presents the synthesis of new derivatives of spirooxindole-spiropiperidinone- pyrrolidines 6a–j and spirooxindole-spiropiperidinone-pyrrolizines 8a–j, through a 1,3-dipolar cycloaddition reaction of azomethineylides generated from isatin ...
Huwaida M. E. Hassaneen +4 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2022 In the presence of copper sulfate, three- or four-component reactions of 2-methylindole, aromatic aldehydes and various cyclic dienophiles in refluxing toluene afforded diverse spirotetrahydrocarbazoles.
Shao-Cong Zhan +3 more
doaj +1 more source
Molecules, 2021 Straightforward regio- and diastereoselective synthesis of bi-spirooxindole-engrafted rhodanine analogs 5a–d were achieved by one-pot multicomponent [3 + 2] cycloaddition (32CA) reaction of stabilized azomethine ylide (AYs 3a–d) generated in situ by ...
Assem Barakat +6 more
doaj +1 more source
Non-Covalent Organocatalyzed Domino Reactions Involving Oxindoles: Recent Advances
Molecules, 2017 The ubiquitous presence of spirooxindole architectures with several functionalities and stereogenic centers in bioactive molecules has been appealing for the development of novel methodologies seeking their preparation in high yields and selectivities ...
Tecla Gasperi +3 more
doaj +1 more source
Sonochemical multi-component synthesis of spirooxindoles
Ultrasonics Sonochemistry, 2011 New and efficient multi-component methods have been developed for the synthesis of spirooxindoles in the presence of a catalytic amount of p-TSA as an inexpensive and available catalyst in EtOH under ultrasound irradiation. The method is simple, starts from readily accessible commercial starting materials, and provides biologically interesting products
Minoo, Dabiri +3 more
openaire +2 more sources
Deciphering Tryptophan Oxygenation: Key Modulators of 2‐Oxindole Formation in MarE
Angewandte Chemie, Volume 137, Issue 35, August 25, 2025.This study reveals that MarE, a heme‐dependent aromatic oxygenase, favors dioxygenation of β‐methyl‐l‐tryptophan in the absence of ascorbate and demonstrates how structural and redox tuning shifts its reactivity toward selective monooxygenation, yielding a 2‐oxindole scaffold. These findings offer new insights into enzyme‐controlled indole oxidation in
Romie C. Nguyen, Inchul Shin, Aimin Liu
wiley +2 more sources
Spirooxindole derivative SOID-8 induces apoptosis associated with inhibition of JAK2/STAT3 signaling in melanoma cells. [PDF]
PLoS ONE, 2012 Melanoma is generally refractory to current chemotherapy, thus new treatment strategies are needed. In this study, we synthesized a series of spirooxindole derivatives (SOID-1 to SOID-12) and evaluated their antitumor effects on melanoma.
Yan Tian +10 more
doaj +1 more source
Angewandte Chemie, Volume 137, Issue 33, August 11, 2025.A binary organic–inorganic acid cooperative catalytic system has been developed to achieve highly enantioselective electrochemical oxidative rearrangement of indoles. The use of electricity as an oxidant in this case showed several advantages including environmental benignity and improved enantiocontrol.
Xuefeng Tan +3 more
wiley +2 more sources