Results 41 to 50 of about 2,159 (193)
Beilstein Journal of Organic Chemistry, 2022 In the presence of copper sulfate, three- or four-component reactions of 2-methylindole, aromatic aldehydes and various cyclic dienophiles in refluxing toluene afforded diverse spirotetrahydrocarbazoles.
Shao-Cong Zhan +3 more
doaj +1 more source
Frontiers in Chemistry, 2021 The tumor resistance to p53 activators posed a clinical challenge. Combination studies disclosed that concomitant administration of Bcl2 inhibitors can sensitize the tumor cells and induce apoptosis.
Yasmine M. Abdel Aziz +11 more
doaj +1 more source
Deciphering Tryptophan Oxygenation: Key Modulators of 2‐Oxindole Formation in MarE
Angewandte Chemie, Volume 137, Issue 35, August 25, 2025.This study reveals that MarE, a heme‐dependent aromatic oxygenase, favors dioxygenation of β‐methyl‐l‐tryptophan in the absence of ascorbate and demonstrates how structural and redox tuning shifts its reactivity toward selective monooxygenation, yielding a 2‐oxindole scaffold. These findings offer new insights into enzyme‐controlled indole oxidation in
Romie C. Nguyen, Inchul Shin, Aimin Liu
wiley +2 more sources
Non-Covalent Organocatalyzed Domino Reactions Involving Oxindoles: Recent Advances
Molecules, 2017 The ubiquitous presence of spirooxindole architectures with several functionalities and stereogenic centers in bioactive molecules has been appealing for the development of novel methodologies seeking their preparation in high yields and selectivities ...
Tecla Gasperi +3 more
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Sonochemical multi-component synthesis of spirooxindoles
Ultrasonics Sonochemistry, 2011 New and efficient multi-component methods have been developed for the synthesis of spirooxindoles in the presence of a catalytic amount of p-TSA as an inexpensive and available catalyst in EtOH under ultrasound irradiation. The method is simple, starts from readily accessible commercial starting materials, and provides biologically interesting products
Minoo, Dabiri +3 more
openaire +2 more sources
Molecules, 2023 A novel series of nitrostyrene-based spirooxindoles were synthesized via the reaction of substituted isatins 1a–b, a number of α-amino acids 2a–e and (E)-2-aryl-1-nitroethenes 3a–e in a chemo/regio-selective manner using [3+2] cycloaddition (Huisgen ...
Richa Sharma +12 more
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Angewandte Chemie, Volume 137, Issue 33, August 11, 2025.A binary organic–inorganic acid cooperative catalytic system has been developed to achieve highly enantioselective electrochemical oxidative rearrangement of indoles. The use of electricity as an oxidant in this case showed several advantages including environmental benignity and improved enantiocontrol.
Xuefeng Tan +3 more
wiley +2 more sources
Spirooxindole derivative SOID-8 induces apoptosis associated with inhibition of JAK2/STAT3 signaling in melanoma cells. [PDF]
PLoS ONE, 2012 Melanoma is generally refractory to current chemotherapy, thus new treatment strategies are needed. In this study, we synthesized a series of spirooxindole derivatives (SOID-1 to SOID-12) and evaluated their antitumor effects on melanoma.
Yan Tian +10 more
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Frontiers in Oncology, 2022 Simultaneous inhibition of more than one target is considered to be a novel strategy in cancer therapy. Owing to the importance of histone deacetylases (HDACs) and p53-murine double minute 2 (MDM2) interaction in tumor development and their synergistic ...
Qian Zhao +9 more
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A synergetic effect of sonication with yolk-shell nanocatalyst for green synthesis of spirooxindoles
Green Chemistry Letters and Reviews, 2021 A synergetic effect of ultrasonic irradiation and yolk–shell nanocatalyst was examined for the synthesis of spirooxindoles from isatin, malononitrile and cyclohexanone.
Somaye Mohammadi, Hossein Naeimi
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