Results 51 to 60 of about 2,159 (193)

The Synthesis of 3-Spirooxindole Derivatives. IV. The Conversion of 3-Spirooxindole to Indole Derivative.

Chemical and Pharmaceutical Bulletin, 1963
The conversion of 1-methylspiro (indoline-3, 1'-indolizine)-2-one to 12-methyl-1, 2, 3, 4, 6, 7, 12, 12b-octahydroindolo [2, 3-a] quinolizine is described as a preliminary for the chemical correlation of N-methylrhynchophyllane with N-methyldihydrocorynantheane.
T, OISHI, S, MAENO, Y, BAN
openaire   +3 more sources

An Efficient Green Approach for the Synthesis of Structurally Diversified Spirooxindoles Using Sulfonic Acid Functionalized Nanoporous Silica (SBA-Pr-SO3H) [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2016
One-pot multicomponent reaction between isatin, barbituric acid, and 6-amino-1,3-dimethyl uracil was investigated in the presence of sulfonic acid functionalized nanoporous silica (SBA-Pr-SO3H) and resulted in the formation of spirooxindole dipyrimidines.
Ghodsi Mohammadi Ziarani, Faezeh Aleali, Negar Lashgari, Alireza Badiei   +3 more
doaj  

Therapeutic Potential of Spirooxindoles as Antiviral Agents [PDF]

ACS Infectious Diseases, 2016
Antiviral therapeutics with profiles of high potency, low resistance, panserotype, and low toxicity remain challenging, and obtaining such agents continues to be an active area of therapeutic development. Due to their unique three-dimensional structural features, spirooxindoles have been identified as privileged chemotypes for antiviral drug ...
Na, Ye, Haiying, Chen, Eric A, Wold, Pei-Yong, Shi, Jia, Zhou   +4 more
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Ultrasound-Promoted One-Pot, Three-Component Synthesis of Spiro[indoline-3,1'-pyrazolo[1,2-<em>b</em>]phthalazine] Derivatives<em></em>

Molecules, 2012
A series of 3'-aminospiro[indoline-3,1'-pyrazolo[1,2-<em>b</em>]phthalazine]-2,5',10'-trione derivatives have been synthesized by a one-pot three-component reaction of isatin, malononitrile or ethyl cyanoacetate and ...
Daqing Shi, Yi Zou, Wei Lin, Yucheng Wang, Changliang Xu, Xiaoguang Bai, Juxian Wang   +6 more
doaj   +1 more source

Advances in Enaminomaleimides Chemistry: Synthesis, Chemical Applications, and Perspectives

ChemistryEurope, Volume 3, Issue 5, September 18, 2025.
Enaminomaleimides are versatile building blocks for the construction of functionalized heterocycles. Their unique nucleophilic character, contrasting with the classical electrophilic nature of maleimides, enables diverse synthetic applications, showing promising potential in both materials science and medicinal chemistry.
Adrián López‐Francés, Birane Diop, Xingyu Jiang, Jean Rodriguez, Muriel Amatore, Thierry Constantieux   +5 more
wiley   +1 more source

Selective construction of dispiro[indoline-3,2'-quinoline-3',3''-indoline] and dispiro[indoline-3,2'-pyrrole-3',3''-indoline] via three-component reaction

Beilstein Journal of Organic Chemistry, 2023
A convenient synthetic procedure for the construction of novel dispirooxindole motifs was successfully developed by base-promoted three-component reaction of ammonium acetate, isatins and in situ-generated 3-isatyl-1,4-dicarbonyl compounds.
Ziying Xiao, Fengshun Xu, Jing Sun, Chao-Guo Yan   +3 more
doaj   +1 more source

Crystal structure and Hirshfeld surface analysis of ethyl 6′-amino-2′-(chloromethyl)-5′-cyano-2-oxo-1,2-dihydrospiro[indoline-3,4′-pyran]-3′-carboxylate

Acta Crystallographica Section E: Crystallographic Communications, 2021
The molecular conformation of the title compound, C17H14ClN3O4, is stabilized by an intramolecular C—H...O contact, forming an S(6) ring motif. In the crystal, the molecules are connected by N—H...O hydrogen-bond pairs along the b-axis direction as ...
Farid N. Naghiyev, Maria M. Grishina, Victor N. Khrustalev, Mehmet Akkurt, Afet T. Huseynova, Anzurat A. Akobirshoeva, İbrahim G. Mamedov   +6 more
doaj   +1 more source

Additive-assisted regioselective 1,3-dipolar cycloaddition of azomethine ylides with benzylideneacetone

Beilstein Journal of Organic Chemistry, 2014
1,3-Dipolar cycloadditions of isatins, benzylamine and benzylideneacetones were studied to prepare a series of novel spiropyrrolidine-oxindoles – 4′-acetyl-3′,5′-diarylspiro[indoline-3,2′-pyrrolidin]-2-ones and 3′-acetyl-4′,5′-diarylspiro[indoline-3,2 ...
Chuqin Peng, Jiwei Ren, Jun-An Xiao, Honggang Zhang, Hua Yang, Yiming Luo   +5 more
doaj   +1 more source

Efficient Synthesis of 2,3′-Spirobi (Indolin)-2′-Ones and Preliminary Evaluation of Their Damage to Mitochondria in HeLa Cells

Frontiers in Pharmacology, 2022
A novel formal (4 + 1) annulation between N-(o-chloromethyl)aryl amides and 3-chlorooxindoles through in situ generated aza-ortho-QMs with 3-chlorooxindoles is reported for the synthesis of a series of 2,3′-spirobi (indolin)-2′-ones in high yields. Under
Huajie Li, Huajie Li, Zhenjie Yu, Zhenjie Yu, Haoyi Sun, Haoyi Sun, Bo Liu, Bo Liu, Xin Wang, Xin Wang, Zhe Shao, Zhe Shao, Meiling Wang, Meiling Wang, Weilin Xie, Weilin Xie, Xingang Yao, Qingqiang Yao, Qingqiang Yao, Ying Zhi, Ying Zhi   +20 more
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Stereoselective Synthesis of Spirooxindole Amides through Nitrile Hydrozirconation [PDF]

Organic Letters, 2010
Spirooxindole amides can be prepared by the intramolecular addition of functionalized indoles into acylimines that are accessed from nitriles by hydrozirconation and acylation. The stereochemical outcome at the quaternary center was controlled by the steric bulk of the substituent at the 2-position of the indole unit.
Chunliang, Lu, Qing, Xiao, Paul E, Floreancig   +2 more
openaire   +2 more sources