Results 71 to 80 of about 2,159 (193)

Cooperative Vinylogous Enamine and Metal Catalysis

ChemCatChem, Volume 17, Issue 7, April 4, 2025.
This review describes transformations combining vinylogous enamine catalysis with transition metal or Lewis acid catalysis that have emerged since the seminal report of dienamine catalysis in 2006. These transformations span numerous reaction classes, including alkylation, allylation, propargylation, oxyamination, dimerization, as well as cascade ...
Stacey E. Brenner‐Moyer
wiley   +1 more source

Exploring pyrrolidinyl-spirooxindole natural products as promising platforms for the synthesis of novel spirooxindoles as EGFR/CDK2 inhibitors for halting breast cancer cells

Frontiers in Chemistry
Cancer represents a global challenge, and the pursuit of developing new cancer treatments that are potent, safe, less prone to drug resistance, and associated with fewer side effects poses a significant challenge in cancer research and drug discovery ...
Mohamed S. Nafie, Mohamed S. Nafie, Abdullah Mohammed Al-Majid, M. Ali, Abdulmajeed Abdullah Alayyaf, Matti Haukka, Sajda Ashraf, Zaheer Ul-Haq, Ayman El-Faham, Assem Barakat   +9 more
doaj   +1 more source

Microwave‐Assisted Multicomponent Synthesis of Spirooxindole Dihydropyridine Bisphosphonates

European Journal of Organic Chemistry, Volume 28, Issue 6, February 10, 2025.
A new, simple, catalyst‐ and solvent‐free microwave‐assisted multicomponent method was developed for the synthesis of spirooxindole dihydropyridine bisphosphonates as a new family of compounds by the one‐pot reaction of isatins, β‐ketophosphonates and primary amines.
Bettina Rávai, Áron Soma Németh, Zsolt Kelemen, Erika Bálint   +3 more
wiley   +1 more source

A Regioselective Multicomponent Approach for the Synthesis of Novel 2‐Acetyl‐4‐phenylquinoline Designed Monospiro‐Pyrrolidine and Thiapyrrolizidine Hybrids

Heteroatom Chemistry, Volume 2025, Issue 1, 2025.
A convenient approach for the synthesis of 2‐acetyl‐4‐phenylquinoline designed monospiro‐pyrrolidine/thiapyrrolizidine hybrids has been achieved via a 1,3‐dipolar cycloaddition reaction of various azomethine ylides derived from isatin/acenaphthylene‐1,2‐dione/ninhydrin, ortho‐phenylenediamine and sarcosine/L‐4‐thiazolidinecarboxylic acid with 2‐acetyl ...
Satheeshkumar Rajendran, Arul Murugesan, Shankar Ramasamy, Wangbin Wu   +3 more
wiley   +1 more source

Multicomponent Reaction Discovery: Three-Component Synthesis of Spirooxindoles [PDF]

Organic Letters, 2010
The Lewis acid-catalyzed, three-component reaction of isatin and two 1,3-dicarbonyl compounds is reported. Reactions proceed with high efficiency under mild reaction conditions and with good functional group tolerance to afford spirooxindole pyranochromenedione derivatives.
Bo, Liang, Srinivas, Kalidindi, John A, Porco, Corey R J, Stephenson   +3 more
openaire   +2 more sources

Stereoselective N‐Heterocyclic‐Carbene‐Catalyzed Spiroannulation as an Access Towards Spirobenzofuranone‐Fused Cyclohexenones

Advanced Synthesis &Catalysis, Volume 366, Issue 24, Page 5008-5014, December 17, 2024.
Abstract In this work, we present an organocatalytic spiroannulation method that provides access to spirocyclic benzofuran‐2‐ones. The reaction proceeds via the generation of an azolium dienolate from an α‐bromo‐α,β‐unsaturated aldehyde using a chiral N‐heterocyclic carbene, followed by annulation with benzofuran‐2‐one‐derived alkenes.
Ladislav Lóška, Vojtěch Dočekal, Daniel Čermák, Simona Petrželová, Milan Pour, Ivana Císařová, Klára Konečná, Ondřej Janďourek, Jan Veselý   +8 more
wiley   +1 more source

A thermally-induced, tandem [3,3]-sigmatropic rearrangement/[2 + 2] cycloaddition approach to carbocyclic spirooxindoles

Beilstein Journal of Organic Chemistry, 2010
The synthesis of C3-carbocyclic spirooxindoles was realized by way of an intramolecular [2 + 2] cycloaddition reaction between a vinylidene indolin-2-one and an alkyne.
Kay M. Brummond, Joshua M. Osbourn
doaj   +1 more source

Synthesis and characterization of a new spirooxindole grafted pyrrolidino/piperidine moiety [PDF]

, 2021
yasmine abdel Aziz, Gehad Lotfy, Mohamed Mostafa Said, El Sayed H. El Ashry, El Sayed H. El Tamany, Saied M. Soliman Saied M. Soliman, Matti Haukka, Assem Assem Barakat   +7 more
openalex   +1 more source

Organocatalyzed Asymmetric Cascade Michael/Michael Reaction of α‐Alkylidene Succinimides with a 2‐(Trifluoromethylmethylene)indane‐1,3‐dione

European Journal of Organic Chemistry, Volume 27, Issue 41, November 4, 2024.
A diaminomethylenemalononitrile organocatalyst promoted asymmetric cascade Michael/Michael reactions between a 2‐(trifluoromethylmethylene)indane‐1,3‐dione derivative and α‐alkylidene succinimides, resulting in spiroindane‐1,3‐dione derivatives.
Ryo Tsuyusaki, Kosuke Nakashima, Yasuyuki Matsushima, Shin‐ichi Hirashima, Tsuyoshi Miura   +4 more
wiley   +1 more source

Synthesis of Spirooxindole-O-Naphthoquinone-Tetrazolo[1,5-a]Pyrimidine Hybrids as Potential Anticancer Agents

Molecules, 2018
A series of novel spirooxindole-O-naphthoquinone-tetrazolo[1,5-a]pyrimidine hybrids were designed, synthesized and evaluated as potent antitumor agents.
Liqiang Wu, Yunxia Liu, Yazhen Li
doaj   +1 more source