Isoniazid Hybrids As Potential Antitubercular Agents
ChemistrySelect, Volume 9, Issue 38, October 11, 2024.Molecular hybridization is a rational drug design strategy that combines two or more covalently binding pharmacological agents into a single multifunctional molecule. The present review discusses the recent functionalizing of isoniazid to new hybrids tackling the menace of various forms of drug‐resistant tuberculosis and generating potential leads for ...
Sahil Mishra +2 more
wiley +1 more source
Spirooxadiazoline oxindoles: synthesis and evaluation of anticancer and antimalarial activities [PDF]
, 2017 Cancer is one of the modern world’s most common and deadly non-infectious disease. According to WHO Cancer Report of 2015, it is one of leading causes of morbidity and mortality worldwide with 8.8 million deaths in 2015 and it is expected to rise about ...
Lopes, Elizabeth de Abreu
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Synthesis and cytotoxicity of 2’-benzoyl-1-benzyl-1 ‚- (4-fluorophenyl) -1’, 2 ‚, 5’, 6 ‚, 7’, 7a’-hexahydhydrospiro [indolin-3,3’-pyrrolyzine] -2-one [PDF]
, 2021 INTRODUCERE Este bine cunoscut faptul, că fragmentele oxindolice și pirolizidinice în multe cazuri, determină proprietăţile biologice ale substanţelor.
Bilan, Dmitrii +3 more
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Molecules, 2015 Herein, we report our preliminary results concerning the first promising asymmetric synthesis of highly functionalized 2-oxospiro-[indole-3,4′-(1′,4′-dihydropyridine)] via the reaction of an enamine with isatylidene malononitrile derivatives in the ...
Fernando Auria-Luna +4 more
doaj +1 more source
PROteolysis‐Targeting Chimeras (PROTACs) in leukemia: overview and future perspectives
MedComm, Volume 5, Issue 6, June 2024.Antileukemic PROteolysis‐TArgeting Chimeras (PROTACs) induce degradation of leukemia‐associated targets, including resistance‐conferring mutant forms. PROTACs against leukemia have increased dramatically. Most antileukemic PROTACs, through an event‐driven mechanism, degrade the target potently, quickly, selectively, and with a long duration of action ...
André T. S. Vicente +1 more
wiley +1 more source
Corrigendum to “Novel spirooxindole based benzimidazole scaffold: In vitro, nanoformulation and in vivo studies on anticancer and antimetastatic activity of breast adenocarcinoma” [PDF]
This is a critical needed correction. In Fig. 15, the image corresponding to the lung from mouse treated with 25 mg/kg was taken from the same section of the mouse that was treated with 10 mg/kg. The corrected Fig. 15 [Formula presented] Fig.
Abu-Serie, Marwa M. +9 more
core +1 more source
Synthesis of spirooxindoles with three component reaction between β-ketoesters, malononitrile and isatin derivatives in the presence of Alum.SiO2 nanoparticles as a new nano catalyst [PDF]
, 2015 In this reseaech, some of the spirooxindole derivaties were prepared via β-ketoesters, malonoitrile and isatin derivatives in the presenceAlum.SiO2 NPs as an effective, recyclable and inexpensive catalyst.
Moslemin, Mohamadhosaine +2 more
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From Conventional to Sustainable Catalytic Approaches for Heterocycles Synthesis
ChemSusChem, Volume 17, Issue 8, April 22, 2024.Catalysed synthetic methods, such as transition metals, organocatalysts, photocatalysts, iodine‐catalysed reaction, electrochemical reactions and green innovative methods are of great interest for the sustainable synthesis of heterocyclic compounds, important building blocks for several applications.
Carla Rizzo +4 more
wiley +1 more source
Synthetic applications of the meta photocycloaddition reaction [PDF]
, 2010 The meta photocycloaddition between a substituted aryl ring and alkene affords architecturally complex tricylic intermediates that have been utilised to investigate three different areas of synthetic organic chemistry.
Berritt, Simon
core +1 more source
IUCrData, 2017 In the title compound, C32H30N2O4, two spiro links connect the methyl-substituted pyrrolidine ring to the oxindole and cyclohexanone rings. The cyclohexanone ring is further connected to the dioxalane ring by a third spiro junction.
Kuppan Chandralekha +3 more
doaj +1 more source