Results 81 to 90 of about 2,159 (193)

Recent Advances in the Application of 2‐Aminobenzothiazole to the Multicomponent Synthesis of Heterocycles

ChemistryOpen, Volume 13, Issue 11, November 2024.
This review highlights recent advances in multicomponent reactions using 2‐aminobenzothiazole as a starting material in the synthesis of diverse heterocycles. These reactions enable the efficient and sustainable construction of novel bioactive molecules and pharmaceuticals.
Ramin Javahershenas, Jianlin Han, Mosstafa Kazemi, Peter J. Jervis   +3 more
wiley   +1 more source

Synthesis of Fluorinated Spiroindolenines by Transition Metal‐Catalyzed Indole Dearomatizations

Advanced Synthesis &Catalysis, Volume 366, Issue 20, Page 4244-4252, October 25, 2024.
Abstract A strategy to access fluorinated spiroindolenines has been developed, involving a selective functionalization of indoles with fluorinated moieties and subsequent catalytic dearomatization. Trifluomethylthio (SCF3), diethyl phosphono(difluoromethyl)thio (SCF2P(O)(OEt)2) and (phenylsulfonyl)difluoromethyl (CF2SO2Ph) groups were embedded at the ...
Floris Buttard, Meriem Daghmoum, Mathieu Arribat, Mu‐Yi Chen, Pascal Retailleau, Tatiana Besset, Xavier Guinchard   +6 more
wiley   +1 more source

Facile one-pot, multi-component reaction to synthesize spirooxindole-annulated thiopyran derivatives under environmentally benevolent conditions [PDF]

, 2022
Firouz Matloubi Moghaddam, Bagher Aghamiri   +1 more
openalex   +1 more source

Catalytic Asymmetric Cycloadditions of Cyclic Sulfamidate Imines: Straightforward Access to Chiral N‐Heterocycles

Advanced Synthesis &Catalysis, Volume 366, Issue 19, Page 3926-3942, October 8, 2024.
Abstract Chiral N‐heterocyclic compounds are key structures in natural compounds and pharmaceuticals, and they serve as essential building blocks of functional materials. Catalytic asymmetric cycloaddition reactions represent one of the most efficient synthetic strategies for constructing optically active heterocycles.
Jong‐Un Park, Ju Hyun Kim
wiley   +1 more source

New Organocatalytic Asymmetric Synthesis of Highly Substituted Chiral 2-Oxospiro-[indole-3,4′- (1′,4′-dihydropyridine)] Derivatives

Molecules, 2015
Herein, we report our preliminary results concerning the first promising asymmetric synthesis of highly functionalized 2-oxospiro-[indole-3,4′-(1′,4′-dihydropyridine)] via the reaction of an enamine with isatylidene malononitrile derivatives in the ...
Fernando Auria-Luna, Eugenia Marqués-López, Somayeh Mohammadi, Roghayeh Heiran, Raquel P. Herrera   +4 more
doaj   +1 more source

A Novel Small Molecule p53 Stabilizer for Brain Cell Differentiation

Frontiers in Chemistry, 2019
Brain tumor, as any type of cancer, is assumed to be sustained by a small subpopulation of stem-like cells with distinctive properties that allow them to survive conventional therapies and drive tumor recurrence. Thus, the identification of new molecules
Joana D. Amaral, Dário Silva, Cecília M. P. Rodrigues, Susana Solá, Maria M. M. Santos   +4 more
doaj   +1 more source

5′-Benzylidene-1′′-methyl-4′′-phenyltrispiro[1,3-dioxolane-2,1′-cyclohexane-3′,3′′-pyrrolidine-2′′,3′′′-indole]-4′,2′′′-dione

IUCrData, 2017
In the title compound, C32H30N2O4, two spiro links connect the methyl-substituted pyrrolidine ring to the oxindole and cyclohexanone rings. The cyclohexanone ring is further connected to the dioxalane ring by a third spiro junction.
Kuppan Chandralekha, Deivasigamani Gavaskar, Adukamparai Rajukrishnan Sureshbabu, Srinivasakannan Lakshmi   +3 more
doaj   +1 more source

Construction of Spirooxindole Skeleton Through Intramolecular Dieckmann Cyclization

Natural Products and Bioprospecting, 2017
A highly efficient and direct approach was developed to construct the structurally diverse spirooxindole skeleton, which is an important basic motif in natural products.
Ting Wu, Zhiqiang Pan, Chengfeng Xia
doaj   +1 more source

Regio- and Stereoselective Synthesis of Spirooxindole Pyrrolidine/Piperidine Fused Chromene Aldehyde Derivatives: Molecular Docking Investigation and Antibacterial Evaluation as DNA Gyrase Inhibitors

, 2023
Jasmine Panda, Bishnu Prasad Raiguru, Sabita Nayak, Suhasini Mohapatra, Seetaram Mohapatra, Chita Ranjan Sahoo   +5 more
openalex   +1 more source

Morphological Profiling Identifies the Motor Protein Eg5 as Cellular Target of Spirooxindoles [PDF]

, 2023
Jie Liu, Shubhadip Mallick, Yusheng Xie, Corentin Grassin, Belén Lucas, Beate Schölermann, Axel Pahl, Rebecca Scheel, Carsten Strohmann, Christoph Protzel, Thorsten Berg, Christian Merten, Slava Ziegler, Herbert Waldmann   +13 more
openalex   +1 more source