Results 81 to 90 of about 2,755 (155)

Synthesis of a New Class of Spirooxindole–Benzo[b]Thiophene-Based Molecules as Acetylcholinesterase Inhibitors

Molecules, 2020
A series of new oxindole-based spiro-heterocycles bearing the benzo[b]thiophene motif were synthesized via a 1,3-dipolar cycloaddition reaction and their acetylcholinesterase (AChE) inhibitory activity was evaluated.
Assem Barakat, Saeed Alshahrani, Abdullah Mohammed Al-Majid, M. Ali, Mezna Saleh Altowyan, Mohammad Shahidul Islam, Abdullah Saleh Alamary, Sajda Ashraf, Zaheer Ul-Haq   +8 more
doaj   +1 more source

Organocatalytic Asymmetric Reduction of δ‐Nitro Dienes: a Viable Entry to Functionalized Amines and Highly Substituted Enantioenriched Cyclopentanes

European Journal of Organic Chemistry, Volume 27, Issue 11, March 18, 2024.
A new asymmetric organocatalytic reaction to afford enantioenriched δ‐nitro alkene analogues and their synthetic manipulation are presented. The chiral nitro alkene was further used in a stereoselective cyclization reaction to afford an almost enantiomerically pure highly functionalised cyclopentane featuring five contiguous stereocenters.
Chiara Faverio, Francesca Franco, Giulia Taini, Laura Raimondi, Maurizio Benaglia   +4 more
wiley   +1 more source

Domino Transformations of 3‐Fluoro‐1,2,4‐Triazine Derivatives towards Spirocyclic and Fused Pyridines

Advanced Synthesis &Catalysis, Volume 366, Issue 2, Page 316-322, January 30, 2024.
Abstract A domino SNAr‐ihDA/rDA reaction was developed from rarely exploited 3‐fluoro‐1,2,4‐triazines with bifunctional alkyne tethered nucleophiles to construct various fused non‐aromatic/heteroaromatic bicycles in yields ranging from 56 to 99%, notably within the family of valuable spirooxindole derivatives.
Anthony Lapray, Thomas Martzel, Marie‐Aude Hiebel, Sylvain Oudeyer, Franck Suzenet, Jean‐François Brière   +5 more
wiley   +1 more source

Synthesis of the pentacyclic carbon framework of the PF1270 family of natural products, The [PDF]

, 2014
2014 Summer.Includes bibliographical references.The PF1270 family of natural products contains novel indole alkaloids that display interesting biological activity; the synthesis of these natural products and their analogs could lead to the discovery of ...
Sanchez, Michelle A.
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Синтез і антимікробна активність гексаметилен-N-малеїнімідопохідних спіроіндол- 3,3’-піроло[3,4-с]піролу [PDF]

, 2017
Aim. To synthesize a series of hexamethylene-N-maleinimidospiroindole-3,3’-pyrrolo[3,4-c]pyrrole derivatives, study the antimicrobial activity of the compounds synthesized and compare their antimicrobial activity with the antimicrobial activity of the ...
Filimonova, N. I., Hlebova, K. V., Red’kin, R. G., Shemchuk, L. A., Suymka, Ye. I.   +4 more
core   +2 more sources

Synthesis of Spirooxindole-O-Naphthoquinone-Tetrazolo[1,5-a]Pyrimidine Hybrids as Potential Anticancer Agents

Molecules, 2018
A series of novel spirooxindole-O-naphthoquinone-tetrazolo[1,5-a]pyrimidine hybrids were designed, synthesized and evaluated as potent antitumor agents.
Liqiang Wu, Yunxia Liu, Yazhen Li
doaj   +1 more source

ACTIVITY OF DABCO: CATALYTIC SCOPE IN ORGANIC SYNTHESIS [PDF]

, 2017
1,4-DiAzaBiCyclo[2.2.2.]octane (DABCO) is a good neucleophile and base in number of organic reactions and gaining particular importance as catalyst in synthetic organic chemistry. Catalytic applications of DABCO in various reactions such as cycloaddition
Saikia, Pallabi
core   +1 more source

Exploring pyrrolidinyl-spirooxindole natural products as promising platforms for the synthesis of novel spirooxindoles as EGFR/CDK2 inhibitors for halting breast cancer cells

Frontiers in Chemistry
Cancer represents a global challenge, and the pursuit of developing new cancer treatments that are potent, safe, less prone to drug resistance, and associated with fewer side effects poses a significant challenge in cancer research and drug discovery ...
Mohamed S. Nafie, Mohamed S. Nafie, Abdullah Mohammed Al-Majid, M. Ali, Abdulmajeed Abdullah Alayyaf, Matti Haukka, Sajda Ashraf, Zaheer Ul-Haq, Ayman El-Faham, Assem Barakat   +9 more
doaj   +1 more source

Antibacterial spirooxindole alkaloids from Penicillium brefeldianum inhibit dimorphism of pathogenic smut fungi [PDF]

, 2022
Huajun Shi, Jinyan Jiang, Hang Zhang, Haimei Jiang, Zijie Su, Dandan Liu, Ligang Jie, Fei He   +7 more
openalex   +1 more source

Asymmetric total syntheses of (+)- and (-)-spirotryprostatins A and B [PDF]

, 2003
2003 Spring.Includes bibliographical references.The first published total synthesis of (+)- and (-)-spirotryprostatin B is presented. The synthesis features an asymmetric azomethine ylide [1,3]-dipolar cycloaddition reaction.
Sebahar, Paul Richard
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