Results 81 to 90 of about 3,654 (228)

Organocatalyzed Asymmetric Cascade Michael/Michael Reaction of α‐Alkylidene Succinimides with a 2‐(Trifluoromethylmethylene)indane‐1,3‐dione

European Journal of Organic Chemistry, Volume 27, Issue 41, November 4, 2024.
A diaminomethylenemalononitrile organocatalyst promoted asymmetric cascade Michael/Michael reactions between a 2‐(trifluoromethylmethylene)indane‐1,3‐dione derivative and α‐alkylidene succinimides, resulting in spiroindane‐1,3‐dione derivatives.
Ryo Tsuyusaki, Kosuke Nakashima, Yasuyuki Matsushima, Shin‐ichi Hirashima, Tsuyoshi Miura   +4 more
wiley   +1 more source

ChemInform Abstract: Multicomponent Reaction Discovery: Three‐Component Synthesis of Spirooxindoles. [PDF]

ChemInform, 2010
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Corey R. J. Stephenson, Srinivas Kalidindi, Bo Liang, John A. Porco   +3 more
openaire   +4 more sources

Synthesis of a New Class of Spirooxindole–Benzo[b]Thiophene-Based Molecules as Acetylcholinesterase Inhibitors

Molecules, 2020
A series of new oxindole-based spiro-heterocycles bearing the benzo[b]thiophene motif were synthesized via a 1,3-dipolar cycloaddition reaction and their acetylcholinesterase (AChE) inhibitory activity was evaluated.
Assem Barakat, Saeed Alshahrani, Abdullah Mohammed Al-Majid, M. Ali, Mezna Saleh Altowyan, Mohammad Shahidul Islam, Abdullah Saleh Alamary, Sajda Ashraf, Zaheer Ul-Haq   +8 more
doaj   +1 more source

Recent Advances in the Application of 2‐Aminobenzothiazole to the Multicomponent Synthesis of Heterocycles

ChemistryOpen, Volume 13, Issue 11, November 2024.
This review highlights recent advances in multicomponent reactions using 2‐aminobenzothiazole as a starting material in the synthesis of diverse heterocycles. These reactions enable the efficient and sustainable construction of novel bioactive molecules and pharmaceuticals.
Ramin Javahershenas, Jianlin Han, Mosstafa Kazemi, Peter J. Jervis   +3 more
wiley   +1 more source

Efficient synthesis of spirooxindole-pyrrolizidines and dispirooxindole-piperazines

Synthetic Communications, 2018
A simple and efficient approach for the construction of spirooxindole-pyrrolizidines and dispirooxindole-piperazines by cycloaddition reaction of azomethine ylide generated by isatin and proline has been demonstrated successfully. The formation of two different types of frameworks by two different modes of cycloaddition is explored.
Keshri Nath Tiwari, Taur Prakash Pandurang, Suyash Pant, P. Sreelekha   +3 more
openaire   +2 more sources

Synthesis of Spirooxindole-O-Naphthoquinone-Tetrazolo[1,5-a]Pyrimidine Hybrids as Potential Anticancer Agents

Molecules, 2018
A series of novel spirooxindole-O-naphthoquinone-tetrazolo[1,5-a]pyrimidine hybrids were designed, synthesized and evaluated as potent antitumor agents.
Liqiang Wu, Yunxia Liu, Yazhen Li
doaj   +1 more source

Synthesis of Fluorinated Spiroindolenines by Transition Metal‐Catalyzed Indole Dearomatizations

Advanced Synthesis &Catalysis, Volume 366, Issue 20, Page 4244-4252, October 25, 2024.
Abstract A strategy to access fluorinated spiroindolenines has been developed, involving a selective functionalization of indoles with fluorinated moieties and subsequent catalytic dearomatization. Trifluomethylthio (SCF3), diethyl phosphono(difluoromethyl)thio (SCF2P(O)(OEt)2) and (phenylsulfonyl)difluoromethyl (CF2SO2Ph) groups were embedded at the ...
Floris Buttard, Meriem Daghmoum, Mathieu Arribat, Mu‐Yi Chen, Pascal Retailleau, Tatiana Besset, Xavier Guinchard   +6 more
wiley   +1 more source

Catalytic Asymmetric Cycloadditions of Cyclic Sulfamidate Imines: Straightforward Access to Chiral N‐Heterocycles

Advanced Synthesis &Catalysis, Volume 366, Issue 19, Page 3926-3942, October 8, 2024.
Abstract Chiral N‐heterocyclic compounds are key structures in natural compounds and pharmaceuticals, and they serve as essential building blocks of functional materials. Catalytic asymmetric cycloaddition reactions represent one of the most efficient synthetic strategies for constructing optically active heterocycles.
Jong‐Un Park, Ju Hyun Kim
wiley   +1 more source

Visible Light‐Mediated Multicomponent Synthesis of Spirooxindole‐Linked Fused Pyrans: An Eco‐Friendly One‐Pot Strategy

ChemistrySelect, Volume 9, Issue 37, October 4, 2024.
We report a visible‐light‐mediated, catalyst‐free multicomponent reaction for the efficient synthesis of spirooxindole‐linked fused pyrans. The reaction involves isatin, malononitrile or its derivatives, and various cyclic 1,3‐dicarbonyl compounds such as 4‐hydroxy‐1‐methyl‐2(1H)‐quinolone, 4‐hydroxycoumarin, 4‐hydroxythiocoumarin, or barbituric acid ...
Nurabul Mondal, Darshika Singh, Vidya Kumari, Lokman H. Choudhury   +3 more
wiley   +1 more source

Isoniazid Hybrids As Potential Antitubercular Agents

ChemistrySelect, Volume 9, Issue 38, October 11, 2024.
Molecular hybridization is a rational drug design strategy that combines two or more covalently binding pharmacological agents into a single multifunctional molecule. The present review discusses the recent functionalizing of isoniazid to new hybrids tackling the menace of various forms of drug‐resistant tuberculosis and generating potential leads for ...
Sahil Mishra, Gobind Kumar, Parvesh Singh   +2 more
wiley   +1 more source