Results 111 to 120 of about 53,406 (189)

Interactome analysis brings splicing into focus [PDF]

, 2015
The spliceosome is a huge molecular machine that assembles dynamically onto its pre-mRNA substrates. A new study based on interactome analysis provides clues about how splicing-regulatory proteins modulate assembly of the spliceosome to either activate ...
Burge, Christopher B., Dominguez, Daniel
core   +2 more sources

Mutations in spliceosome genes and therapeutic opportunities in myeloid malignancies

Genes, Chromosomes and Cancer, 2019
Since the discovery of RNA splicing more than 40 years ago, our comprehension of the molecular events orchestrating constitutive and alternative splicing has greatly improved.
Justin Taylor, Stanley C. Lee
semanticscholar   +1 more source

All-Atom Simulations Decrypt the Molecular Terms of RNA Catalysis in the Exon-Ligation Step of the Spliceosome

, 2020
The spliceosome, a protein-directed metallo-ribozyme, catalyzes premature mRNA splicing via two transesterification reactions.
J. Borišek, A. Magistrato
semanticscholar   +1 more source

The PSI-U1 snRNP interaction regulates male mating behavior in Drosophila

, 2016
Alternative pre-mRNA splicing (AS) is a critical regulatory mechanism that operates extensively in the nervous system to produce diverse protein isoforms.
Hilgers, V., Klibaite, U., Rio, D., Shaevitz, J., Taliaferro, J., Wang, Q.   +5 more
core   +1 more source

Structural studies of the spliceosome: Bridging the gaps

Current Opinion in Structural Biology, 2022
J. Tholen, W. P. Galej
semanticscholar   +1 more source

Editorial: Therapeutic targeting of splicing variants in cancer

Frontiers in Pharmacology, 2023
Pouya Sarvari, Karla Rubio, Karla Rubio, Stephanie Dobersch, Aglaia Ntokou, Aglaia Ntokou, Verónica Vallejo-Ruiz   +6 more
doaj   +1 more source

Structures of the human pre-catalytic spliceosome and its precursor spliceosome

Cell Research, 2018
The pre-catalytic spliceosome (B complex) is preceded by its precursor spliceosome (pre-B complex) and followed by the activated spliceosome (Bact complex).
X. Zhan, Chuangye Yan, Xiaofeng Zhang, Jianlin Lei, Yigong Shi   +4 more
semanticscholar   +1 more source

Exploring RNA-targeted gene therapy approaches for hypertrophic cardiomyopathy [PDF]

, 2012
Relatório de projeto no âmbito do Programa de Bolsas Universidade de Lisboa/Fundação Amadeu Dias (2011/2012). Universidade de Lisboa.
Freitas, Ana
core  

Proteome and Phosphoproteome Profiling Reveal the Toxic Mechanism of Clostridium perfringens Epsilon Toxin in MDCK Cells

Toxins
Epsilon toxin (ETX), a potential agent of biological and toxic warfare, causes the death of many ruminants and threatens human health. It is crucial to understand the toxic mechanism of such a highly lethal and rapid course toxin.
Nan Yue, Jing Huang, Mingxin Dong, Jiaxin Li, Shan Gao, Jing Wang, Yingshuang Wang, Dongxue Li, Xi Luo, Tingting Liu, Songyang Han, Lina Dong, Ming Chen, Jinglin Wang, Na Xu, Lin Kang, Wenwen Xin   +16 more
doaj   +1 more source

The Spliceosome: Design Principles of a Dynamic RNP Machine

Cell, 2009
M. Wahl, C. Will, R. Lührmann
semanticscholar   +1 more source