Results 121 to 130 of about 53,406 (189)

H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers

Nature Network Boston, 2018
M. Seiler, A. Yoshimi, Rachel B. Darman, B. Chan, G. Keaney, Michael Thomas, Anant A. Agrawal, B. Caleb, A. Csibi, E. Sean, P. Fekkes, C. Karr, V. Klimek, G. Lai, Linda Lee, Pavan Kumar, Stanley C. Lee, Xiang Liu, C. Mackenzie, Carol Meeske, Y. Mizui, E. Padron, Eunice S. Park, Ermira Pazolli, Shouyong Peng, Sudeep Prajapati, Justin Taylor, Teng Teng, John Y. Wang, M. Warmuth, Huilan Yao, Lihua Yu, P. Zhu, O. Abdel-Wahab, Peter G. Smith, S. Buonamici   +35 more
semanticscholar   +1 more source

Kiyoshi Nagai (1949-2019).

, 2020
Lührmann, R.
core   +1 more source

Reporting a Homozygous Case of Neurodevelopmental Disorder Associated With a Novel PRPF8 Variant

Molecular Genetics & Genomic Medicine
Background While recently identified heterozygous PRPF8 variants have been linked to various human diseases, their role in neurodevelopmental disorders (NDDs) remains ambiguous.
Mohammad Reza Mirinezhad, Farzaneh Mirzaei, Arash Salmaninejad, Reza Jafarzadeh Esfehani, Mohammad Reza Seyedtaghia, Sheyda Farahmand, Mehran Beiraghi Toosi, Somayyeh Hashemian, M. E. Suzzane Lewis   +8 more
doaj   +1 more source

A Novel tRF, HCETSR, Derived From tRNA‐Glu/TTC, Inhibits HCC Malignancy by Regulating the SPBTN1‐catenin Complex Axis

Advanced Science
tRNA‐derived fragments (tRFs), a novel class of small non‐coding RNAs cleaved from transfer RNAs, have been implicated in tumor regulation. In this study, the role of a specific tRF, HCETSR is investigated, which is significantly downregulated in ...
Tao Rui, Kangbei Zhu, Zonglei Mao, Jiaping Wu, Yi Pan, Qianwei Ye, Cong Chen, Aizhai Xiang, Jufeng Guo, Ning Tang, Jing Zhang, Shusen Zheng, Jian Liu, Xiao Xu   +13 more
doaj   +1 more source

A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation

Science, 2019
S. Fica, C. Oubridge, M. E. Wilkinson, A. Newman, K. Nagai   +4 more
semanticscholar   +1 more source

Splicing and transcription touch base: co-transcriptional spliceosome assembly and function

Nature reviews. Molecular cell biology, 2017
Lydia Herzel, D. Ottoz, T. Alpert, K. Neugebauer   +3 more
semanticscholar   +1 more source

Swt21p Is Required for Nam8p-U1 snRNP Association and Efficient Pre-mRNA Splicing in <i>Saccharomyces cerevisiae</i>. [PDF]

Int J Mol Sci
Lin K, Fu X, Wang L, Xiao S, Wang S, Fan Y, An X, Boon KL, Bao P.   +8 more
europepmc   +1 more source

Pre-mRNA Splicing Functions in Plant Sexual Reproduction Development. [PDF]

Plants (Basel)
Shao D, Gao X, Wei Y.
europepmc   +1 more source

Splice it hot: How nuclear PP2A B'η regulates splicing fidelity by targeting the heat-stressed spliceosome. [PDF]

Plant Cell
Wang J.
europepmc   +1 more source

Impaired splicing machinery in craniopharyngiomas unveils PRPF8 and RAVER1 as novel biomarkers and therapeutic targets. [PDF]

Acta Neuropathol Commun
Fuentes-Fayos AC, G-García ME, Sánchez-Medianero T, Apps J, Flores-Martínez Á, De la Rosa-Herencia AS, Gil-Duque I, Otto G, Venegas-Moreno E, Ruiz-Valdepeñas EC, Herrera-Martínez AD, Solivera J, Gahete MD, Cano DA, Ortega R, Soto-Moreno A, Gálvez-Moreno MA, Martínez-Barberá JP, Luque RM.   +18 more
europepmc   +1 more source