Results 21 to 30 of about 111,466 (171)
Diverse Requirements for Src-Family Tyrosine Kinases Distinguish Chlamydial Species
mBio, 2011 Chlamydiae are well known for their species specificity and tissue tropism, and yet the individual species and strains show remarkable genomic synteny and share an intracellular developmental cycle unique in the microbial world.
Jeffrey Mital, Ted Hackstadt
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Targeting Src family kinases inhibits bevacizumab-induced glioma cell invasion. [PDF]
PLoS ONE, 2013 Anti-VEGF antibody therapy with bevacizumab provides significant clinical benefit in patients with recurrent glioblastoma multiforme (GBM). Unfortunately, progression on bevacizumab therapy is often associated with a diffuse disease recurrence pattern ...
Deborah Huveldt +8 more
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Journal of Inflammation, 2006 Background Yeast and bacteria elicit arachidonate release in macrophages, leading to the formation of leukotrienes and prostaglandins, important mediators of inflammation.
Sundler Roger, Olsson Sandra
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Regulation of Src and Csk nonreceptor tyrosine kinases in the filasterean Ministeria vibrans [PDF]
, 2014 ACS AuthorChoice - This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.The development of the phosphotyrosine-based signaling ...
Craddock, Barbara P. +3 more
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Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk
BMC Immunology, 2001 Background The Tec family kinases are implicated in signaling from lymphocyte antigen receptors and are activated following phosphorylation by Src kinases.
Debnath Jayanta +6 more
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Frontiers in Immunology, 2017 In a synthetic biology approach using Schneider (S2) cells, we show that SLP-76 is directly phosphorylated at tyrosines Y113 and Y128 by SYK in the presence of ITAM-containing adapters such as CD3ζ, DAP12, or FcεRγ.
Frank Fasbender +4 more
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Structure and regulation of Src family kinases [PDF]
Oncogene, 2004 Src family kinases are prototypical modular signaling proteins. Their conserved domain organization includes a myristoylated N-terminal segment followed by SH3, SH2, and tyrosine kinase domains, and a short C-terminal tail. Structural dissection of Src kinases has elucidated the canonical mechanisms of phosphotyrosine recognition by the SH2 domain and ...
Titus J, Boggon, Michael J, Eck
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Profiling Y561-dependent and -independent substrates of CSF-1R in epithelial cells. [PDF]
PLoS ONE, 2010 Receptor tyrosine kinases (RTKs) activate multiple downstream cytosolic tyrosine kinases following ligand stimulation. SRC family kinases (SFKs), which are recruited to activated RTKs through SH2 domain interactions with RTK autophosphorylation sites ...
Melodie L Knowlton +7 more
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c-Src drives intestinal regeneration and transformation [PDF]
, 2014 The non‐receptor tyrosine kinase c‐Src, hereafter referred to as Src, is overexpressed or activated in multiple human malignancies. There has been much speculation about the functional role of Src in colorectal cancer (CRC), with Src amplification and ...
Cordero, Julia B. +7 more
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Src kinases are required for a balanced production of IL-12/IL-23 in human dendritic cells activated by Toll-like receptor agonists. [PDF]
PLoS ONE, 2010 BACKGROUND: Pathogen recognition by dendritic cells (DC) is crucial for the initiation of both innate and adaptive immune responses. Activation of Toll-like Receptors (TLRs) by microbial molecular patterns leads to the maturation of DC, which present the
Mirela Kuka +7 more
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