Results 31 to 40 of about 111,466 (171)

Binding, domain orientation, and dynamics of the Lck SH3-SH2 domain pair and comparison with other Src-family kinases [PDF]

, 2005
The catalytic activity of Src-family kinases is regulated by association with its SH3 and SH2 domains. Activation requires displacement of intermolecular contacts by SH3/SH2 binding ligands resulting in dissociation of the SH3 and SH2 domains from the ...
Bolen J. B., Brown M. T., Thomas S. M., Williams J. C., Xu W., Sicheri F., Mustelin T., Moarefi I., Young M. A., Eck M. J., Arold S. T., Fushman D., Ulmer T. S., Schweimer K., Chou J. J., Ruckert M., Kay L. E., Kay L. E., Farrow N. A., Boyd J., Kay L. E., Werner J. M., Lipari G., Palmer A. G., Mandel A. M., Boyd J., Woessner D. E., Press W. H., Ottiger M., Dosset P., Morton C. J., Schweimer K., Hartley D. A., Wiese N., Songyang Z., Morelock M. M., Bauer F., Courtneidge S. A., Kaplan D. R., Dunant N. M., Pelosi M., Tjandra N., Losonczi J. A., Clore G. M., Zamoyska R., Abbreviations HMTA   +45 more
core   +2 more sources

Characterization of Novel Src Family Kinase Inhibitors to Attenuate Microgliosis. [PDF]

PLoS ONE, 2015
Microgliosis is a major hallmark of Alzheimer's disease (AD) brain pathology. Aβ peptide is hypothesized to act as a stimulus for microglia leading to activation of non-receptor tyrosine kinases and subsequent secretion of pro-inflammatory cytokines ...
Gunjan D Manocha, Kendra L Puig, Susan A Austin, Kathleen Seyb, Marcie A Glicksman, Colin K Combs   +5 more
doaj   +1 more source

Inhibition of Food Intake by PACAP in the Hypothalamic Ventromedial Nuclei is Mediated by NMDA Receptors [PDF]

, 2014
Central injections of pituitary adenylate cyclase-activating polypeptide (PACAP) into the ventromedial nuclei (VMN) of the hypothalamus produce hypophagia that is dependent upon the PAC1 receptor; however, the signaling downstream of this receptor in the
Choi, Sujean, Maunze, Brian, Phillips, Kailynn A., Resch, Jon M   +3 more
core   +2 more sources

The Src family kinases: distinct functions of c-Src, Yes, and Fyn in the liver

Biomolecular Concepts, 2013
The Src family kinases Yes, Fyn, and c-Src play a pivotal role in regulating diverse liver functions such as bile flow, proteolysis, apoptosis, and proliferation and are regulated by anisoosmotic cell volume changes, death receptor ligands, and bile ...
Reinehr Roland, Sommerfeld Annika, Häussinger Dieter   +2 more
doaj   +1 more source

Src Family Kinases and p38 Mitogen-Activated Protein Kinases Regulate Pluripotent Cell Differentiation in Culture. [PDF]

PLoS ONE, 2016
Multiple pluripotent cell populations, which together comprise the pluripotent cell lineage, have been identified. The mechanisms that control the progression between these populations are still poorly understood.
Boon Siang Nicholas Tan, Joly Kwek, Chong Kum Edwin Wong, Nicholas J Saner, Charlotte Yap, Fernando Felquer, Michael B Morris, David K Gardner, Peter D Rathjen, Joy Rathjen   +9 more
doaj   +1 more source

Ca²⁺ Signaling and Src Functions in Tumor Cells

Biomolecules, 2023
Signaling by calcium ion (Ca2+) plays a prominent role in cell physiology, and these mechanisms are frequently altered in tumor cells. In this review, we consider the interplay of Ca2+ signaling and the functions of the proto-oncogene non-receptor ...
Antonio Villalobo
doaj   +1 more source

Essential Role of Lyn in Fibrosis. [PDF]

, 2016
Fibrotic disorders involve replacement of normal parenchyma with myofibroblasts, which deposit connective tissue, leading to obliteration of the function of the underlying organ.
Birtolo, Chiara, Chheda, Chintan, Cirulli, Vincenzo, Gugliotta, Gabriele, Lewis, Michael S, Liu, Sandy T, Pandol, Stephen J, Pham, Hung, Ptasznik, Andrzej, Rodriguez, Maria D, Yang, Wendy   +10 more
core   +2 more sources

Recruitment of Lyn from endomembranes to the plasma membrane through calcium-dependent cell-cell interactions upon polarization of inducible Lyn-expressing MDCK cells

Scientific Reports, 2017
Src-family kinases, expressed in a wide variety of cell types, are anchored to cellular membranes through posttranslational lipid modifications and involved in diverse cellular signalling.
Takao Morinaga, Sayuri Yanase, Aya Okamoto, Noritaka Yamaguchi, Naoto Yamaguchi   +4 more
doaj   +1 more source

Src as the link between inflammation and cancer. [PDF]

, 2013
Although a causal link between chronic inflammation and cancer has been established, the exact molecular mechanism linking inflammation to cancer remains largely unknown.
Andrzej ePtasznik, Hung ePham, Sandy eLiu, Stephen J Pandol, Stephen J Pandol   +4 more
core   +2 more sources

B cell activation triggered by the formation of the small receptor cluster: a computational study. [PDF]

PLoS Computational Biology, 2011
We proposed a spatially extended model of early events of B cell receptors (BCR) activation, which is based on mutual kinase-receptor interactions that are characteristic for the immune receptors and the Src family kinases. These interactions lead to the
Beata Hat, Bogdan Kazmierczak, Tomasz Lipniacki   +2 more
doaj   +1 more source