Results 71 to 80 of about 1,835,204 (269)

Cry2 prompts clock oscillation and temporomandibular joint homeostasis under mechanical loading

Bone & Joint Research
Aims: Cartilage metabolism exhibits circadian rhythms (CR), and disruption of these often correlates with cartilage degeneration. Mechanical stimulation is a vital zeitgeber of CR in cartilage.
Chenzhi Li, Yujie Zhao, Jing Song, Nan Wang, Xiangyan Zhang, Mao Sui, Xuemin Zeng, Xiao Yuan, Dapeng Ren   +8 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The staining potential of the dental enamel with cerium oxide nanoparticle mouthwash and Glycyrrhiza glabra nanoparticle mouthwash: An in vitro study

Journal of Indian Society of Periodontology
Background: This study aims to formulate and evaluate the staining effect of three different types of mouthwash containing nanoparticles (NPs) and compare them with chlorhexidine (CHX) mouthwash on dental enamel.
M. A. Lavanya, H. Esther Nalini, S. R. Bharathi, S. Tamil Selvi, S. Nivethitha, S. Reshma   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Vascular remodelling and fibrotic changes in the joint capsule during periprosthetic knee infections

Bone & Joint Research
Aims: Periprosthetic joint infection (PJI) represents one of the most severe complications following joint arthroplasty, often associated with a high recurrence rate despite appropriate therapeutic interventions. The underlying mechanisms contributing to
Renqiu Qiao, Julia Mehl, Bo Qi, Ellen Sistemich, Wei Fan, Stephanie Kirschbaum, Stefanie Donner, Mario Thiele, Denise Jahn, Clemens Gwinner, Georg Duda, Carsten F. Perka, Arne Kienzle   +12 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Optimizing Antibody Concentrations for Immunohistochemistry in Neurotrauma Research [PDF]

The Young Researcher
Objective/research question: What primary and secondary antibody concentrations optimize the visualization of immunohistochemical (IHC) stains for antigens prevalent in neurotrauma research?
Shriya Singh
doaj  

G-protein-coupled estrogen receptor-1 facilitates chondrocyte proliferation in pubertal epiphyseal growth plate via PTHrP/Ihh regulation

Bone & Joint Research
Aims: Oestrogen drives long-bone development through various oestrogen receptors. G-protein-coupled oestrogen receptor-1 (GPER-1), a membrane oestrogen receptor, mediates longitudinal bone growth during early puberty; however, the underlying mechanisms ...
Ya-Shuan Chou, Sung-Yen Lin, Shu-Chun Chuang, Pei-Yin Shih, Chung-Hwan Chen, Mei-Ling Ho, Je-Ken Chang   +6 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Surface properties and susceptibility to staining of a resin composite after brushing with different whitening toothpastes [PDF]

Restorative Dentistry & Endodontics
Objectives This study investigated the effects of different whitening toothpaste (WT) on the surface properties and staining susceptibility of a resin composite.
Aline da Silva Barros, Carolina Meneghin Barbosa, Renata Siqueira Scatolin, Waldemir Francisco Vieira Junior, Laura Nobre Ferraz   +4 more
doaj   +1 more source