Results 91 to 100 of about 2,206,842 (308)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The staining potential of the dental enamel with cerium oxide nanoparticle mouthwash and Glycyrrhiza glabra nanoparticle mouthwash: An in vitro study

Journal of Indian Society of Periodontology
Background: This study aims to formulate and evaluate the staining effect of three different types of mouthwash containing nanoparticles (NPs) and compare them with chlorhexidine (CHX) mouthwash on dental enamel.
M. A. Lavanya, H. Esther Nalini, S. R. Bharathi, S. Tamil Selvi, S. Nivethitha, S. Reshma   +5 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Vascular remodelling and fibrotic changes in the joint capsule during periprosthetic knee infections

Bone & Joint Research
Aims: Periprosthetic joint infection (PJI) represents one of the most severe complications following joint arthroplasty, often associated with a high recurrence rate despite appropriate therapeutic interventions. The underlying mechanisms contributing to
Renqiu Qiao, Julia Mehl, Bo Qi, Ellen Sistemich, Wei Fan, Stephanie Kirschbaum, Stefanie Donner, Mario Thiele, Denise Jahn, Clemens Gwinner, Georg Duda, Carsten F. Perka, Arne Kienzle   +12 more
doaj   +1 more source

Rapid alkaline methylene blue supravital staining for assessment of anterior segment infections [PDF]

, 2016
Katsuji Kiuchi Kiuchi Eye Clinic, Joto-ku, Osaka, Japan Purpose: To present the Löffler’s alkaline methylene blue technique of staining eye discharges in eyes with anterior segment infections.Method: The Löffler’s alkaline ...
Kiuchi K
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Optimizing Antibody Concentrations for Immunohistochemistry in Neurotrauma Research [PDF]

The Young Researcher
Objective/research question: What primary and secondary antibody concentrations optimize the visualization of immunohistochemical (IHC) stains for antigens prevalent in neurotrauma research?
Shriya Singh
doaj  

A bone histological approach to distinguish periprosthetic joint infection from aseptic osteolysis in revision joint replacement

Bone & Joint Research
Aims: Accurate differentiation between periprosthetic joint infection (PJI) and aseptic osteolysis (AO) remains a major clinical challenge in revision joint arthroplasty.
Dzenita Muratovic, Ryan D. Quarrington, Dongqing Yang, Masakazu Kogawa, Renjy Nelson, Boopalan Ramasamy, Lucian Bogdan Solomon, Gerald J. Atkins   +7 more
doaj   +1 more source

Blinking Patterns and Corneal Staining

, 2006
PURPOSE: To investigate the blinking patterns of healthy subjects and soft contact lens wearers and determine whether these blinking characteristics were associated with corneal fluorescein staining.
Gillon, Russell S., Saunders, Alison, Anthony, Eleni, Hook, Sally, Gillon, Russell, Iskander, D. Robert, Collins, Michael J.   +6 more
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source