Results 81 to 90 of about 4,536 (207)

Inflammation‐Regeneration Axis of Dental Pulp Stem Cells: Wnt/NF‐κB Crosstalk

International Endodontic Journal, EarlyView.
ABSTRACT Background Inflammation critically determines dental pulp regenerative outcomes, with dental pulp stem cells (DPSCs) orchestrating tissue homeostasis through differentiation, self‐renewal and immunomodulation processes dynamically regulated by Wnt/β‐catenin and NF‐κB signaling crosstalk.
V. Rajasekar, M. Huang, M. M. Abdalla, P. Neelakantan, C. K. Y. Yiu   +4 more
wiley   +1 more source

Stem cells from apical papilla-derived exosomes alleviate bisphosphonate-related osteonecrosis of the jaw by promoting angiogenesis

Materials & Design
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a severe, refractory osteonecrosis caused by prolonged bisphosphonate therapy. Stem cells from apical papilla-derived exosomes (SCAP-Exo), measuring 30–150 nm in diameter, have been shown to ...
Xuesong Zhu, Yu Wang, Mingchen Ma, Xiaoli Li, Si Yu, Yao Liu, Aochen Wang   +6 more
doaj   +1 more source

Noncanonical Wnt5a Signaling Suppresses Hippo/TAZ-Mediated Osteogenesis Partly Through the Canonical Wnt Pathway in SCAPs

Drug Design, Development and Therapy, 2022
Yajing Fu,1 Dan Ma,2 Fengyan Fan,3 Tongke Sun,1 Ruiqi Han,1 Yanran Yang,1 Jun Zhang1 1Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration ...
Fu Y, Ma D, Fan F, Sun T, Han R, Yang Y, Zhang J   +6 more
doaj  

Regenerative Endodontics in Teeth With Irreversible Pulpitis: A Scoping Review

International Endodontic Journal, EarlyView.
ABSTRACT Introduction Regenerative endodontic procedures (REPs) have been widely used to manage a range of pulpal pathologies, particularly in immature permanent teeth. The development of bioactive calcium silicate–based materials has led to a paradigm shift in vital pulp therapy (VPT) and REPs.
Mahmoud Torabinejad, Neda Najafimakhsoos, George Bogen   +2 more
wiley   +1 more source

Distinct Microbiota and Functional Pathway Profiles Define Success and Failure in Regenerative Endodontic Treatment

International Endodontic Journal, EarlyView.
ABSTRACT Aim To characterize the intracanal microbiota and identify key microbial taxa and functional pathways associated with regenerative endodontic treatment (RET) outcomes. Methodology In this observational cohort study, 196 samples were collected at five time points from external tooth surfaces (T1, T4) and root canals (T2, T3, T5).
Leimarembi Devi Naorem, Alina Wikström, Peter Quach, Lokeshwaran Manoharan, Ronald Ordinola‐Zapata, Olena Rakhimova, Malin Brundin, Nelly Romani Vestman   +7 more
wiley   +1 more source

Engineering Scaffold-free Dental Organoids Using Human Stem Cells from the Apical Papilla (SCAP) [PDF]

, 2021
The clinical dilemma of treating immature necrotic teeth has been the driving force behind the field of regenerative endodontics. Through evoking bleeding from the periapical tissues, clinicians have noticed root elongation and closure following this ...
Meshry, Nadeen Mahmoud
core  

Roles of basic fibroblast growth factor, stem cells from dental pulp and apical papilla in the repair and regeneration of dental pulp and other tissues/organs

Journal of Dental Sciences
Currently, the concept of regeneration and regenerative therapies are already being applied clinically to treat pulpal and periodontal diseases, as well as to repair and regenerate systemic organs and tissues.
Pin-Hsuan Wu, Yan-Hsiung Wang, Ying-Chu Lin, Ya-Shuan Chou, Mei-Chi Chang, Jiiang-Huei Jeng   +5 more
doaj   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

Effects of different concentrations of MTA on the proliferation and differentiation of stem cells from the apical papilla

口腔疾病防治, 2018
Objective To investigate the effect of different concentrations of MTA on the proliferation and differen⁃ tiation of stem cells from the apical papilla (SCAP) and the potential of the SCAP to differentiate into odontoblasts.
NIU Qiaoli, LI Yiming, SONG Yanyan, LI Chenxi, ZHAO Jin   +4 more
doaj   +1 more source

m6A-Modified GATA2 Enhances Odontogenic Differentiation in Stem Cells from the Apical Papilla

International Journal of Molecular Sciences
Epigenetic modifications play a crucial role in regulating stem cell differentiation. Among these, N6-methyladenosine (m6A) modification significantly impacts mRNA stability and translation. However, its role in dental stem cell differentiation remains largely unexplored.
Haoqing Yang, Fengning Yuan, Jiaxin Song, Yishu Huang, Zhaochen Shan, Zhipeng Fan   +5 more
openaire   +2 more sources