Results 1 to 10 of about 58,847 (252)

The role of proteins implicated in skin steroidogenesis in acne vulgaris development [PDF]

Vestnik Dermatologii i Venerologii, 2023
Background. Acne vulgaris belongs to androgen-dependent diseases where androgens cause sebaceous gland hypertrophy with a subsequent enlargement of sebum production. Aims.
Andrey K. Kirichenko, Yaroslavna V. Bardetskaya, Yuliya A. Fefelova, Kseniya V. Kotova, Victoriya O. Tokmakova, Tatyana G. Ruksha   +5 more
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DEHP Decreases Steroidogenesis through the cAMP and ERK1/2 Signaling Pathways in FSH-Stimulated Human Granulosa Cells

Cells, 2023
DEHP is an endocrine disruptor that interferes with the function of the female reproductive system. Several studies suggested that DEHP affects steroidogenesis in human and rodent granulosa cells (GC).
Biljana Tesic, Dragana Samardzija Nenadov, Tamara Tomanic, Svetlana Fa Nedeljkovic, Stevan Milatovic, Bojana Stanic, Kristina Pogrmic-Majkic, Nebojsa Andric   +7 more
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Hormones and Signaling Pathways Involved in the Stimulation of Leydig Cell Steroidogenesis

Endocrines, 2023
Leydig cells, located in the testis interstitial space, are the primary source of testosterone in males. Testosterone plays critical roles in both reproductive and metabolic functions and therefore is essential for male health.
Karine de Mattos, Kenley Joule Pierre, Jacques J. Tremblay   +2 more
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Fatty acids suppress the steroidogenesis of the MA-10 mouse Leydig cell line by downregulating CYP11A1 and inhibiting late-stage autophagy

Scientific Reports, 2021
Obese men have lower circulating testosterone than men with an optimal body mass index. Elevated fatty acids (FAs) caused by obesity have been reported to suppress the steroidogenesis of Leydig cells.
Chien Huang, Hsiu-Ju Hsu, Mu-En Wang, Meng-Chieh Hsu, Leang-Shin Wu, De-Shien Jong, Yi-Fan Jiang, Chih-Hsien Chiu   +7 more
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The triclosan-induced shift from aerobic to anaerobic metabolism link to increased steroidogenesis in human ovarian granulosa cells

Ecotoxicology and Environmental Safety, 2021
Triclosan (TCS) is an endocrine-disrupting chemical (EDC), which is used ubiquitously as an antimicrobial ingredient in healthcare products and causes contamination in the environment such as air, water, and biosolid-amended soil.
Yatao Du, Bin Wang, Zhenzhen Cai, Huihui Zhang, Bo Wang, Wei Liang, Guangdi Zhou, Fengxiu Ouyang, Weiye Wang   +8 more
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The Expanding Role of Mitochondria, Autophagy and Lipophagy in Steroidogenesis

Cells, 2021
The fundamental framework of steroidogenesis is similar across steroidogenic cells, especially in initial mitochondrial steps. For instance, the START domain containing protein-mediated cholesterol transport to the mitochondria, and its conversion to ...
Geetika Bassi, Simarjit Kaur Sidhu, Suresh Mishra   +2 more
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Prohibitin-1 plays a regulatory role in Leydig cell steroidogenesis

iScience, 2022
Summary: Mitochondria are essential for steroidogenesis. In steroidogenic cells, the initiation of steroidogenesis from cholesterol occurs on the matrix side of the inner mitochondrial membrane by the enzyme P450scc. This requires cholesterol import from
Geetika Bassi, Suresh Mishra
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Fluorene-9-bisphenol regulates steroidogenic hormone synthesis in H295R cells through the AC/cAMP/PKA signaling pathway

Ecotoxicology and Environmental Safety, 2022
Fluorene-9-bisphenol (BHPF), which has been used as a substitute for bisphenol A (BPA) in consumer goods and industrial products, can be detected in environmental media and human urine. BHPF has been reported to have endocrine-disrupting effects, whereas
Yuan Huang, Wei Zhang, Na Cui, Zhiming Xiao, Wenyu Zhao, Ruiguo Wang, John P. Giesy, Xiaoou Su   +7 more
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Development and organisation of gonadal steroidogenesis in bony fishes - A review

Aquaculture and Fisheries, 2021
Gonadal steroidogenesis is pivotal to synchronize various reproductive stages including sexual development, growth and maturation. In all vertebrates including teleost, steroidogenesis is triggered by the mobilization of cholesterol by steroidogenic ...
Swathi Tenugu, Akanksha Pranoty, Sajwan-Khatri Mamta, Balasubramanian Senthilkumaran   +3 more
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Nano-Curcumin Prevents Copper Reproductive Toxicity by Attenuating Oxidative Stress and Inflammation and Improving Nrf2/HO-1 Signaling and Pituitary-Gonadal Axis in Male Rats

Toxics, 2022
Copper is essential for several cellular processes and is an important catalytic factor for many proteins. However, excess copper can provoke oxidative stress and reproductive toxicity.
Wedad S. Sarawi, Ahlam M. Alhusaini, Laila M. Fadda, Hatun A. Alomar, Awatif B. Albaker, Hanan K. Alghibiwi, Amjad S. Aljrboa, Areej M. Alotaibi, Iman H. Hasan, Ayman M. Mahmoud   +9 more
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