Results 161 to 170 of about 10,284 (252)

Orai2 Modulates Store-Operated Ca²⁺ Entry and Cell Cycle Progression in Breast Cancer Cells. [PDF]

Cancers (Basel), 2021
Sanchez-Collado J, Lopez JJ, Cantonero C, Jardin I, Regodón S, Redondo PC, Gordillo J, Smani T, Salido GM, Rosado JA.   +9 more
europepmc   +1 more source

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

Advanced Science, EarlyView.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong, Wenlong Chen, Fanglong Liu, Shengyi Zhou, Bolin Yu, Yuying Wang, Xiqian Zhou, Xuehui Wang, Diya Liu, Zhuoyu Zhang, Xinran Wang, Mounia Lalouly, Yiwen Li, Zhefei Du, Tao Yan, Zhihui Xiao, Zhou Zhou, Huanhuan Zhu, Fengyuan Qian, Bowen Zheng, Lin Fang   +20 more
wiley   +1 more source

Store-operated Ca²⁺ entry is involved in endothelium-to-mesenchymal transition in lung vascular endothelial cells. [PDF]

Am J Physiol Lung Cell Mol Physiol
Babicheva A, Elmadbouh I, Song S, Thompson MA, Powers R, Jain PP, Izadi A, Chen J, Yung L, Parmisano S, Paquin C, Wang WT, Chen Y, Wang T, Alotaibi M, Shyy JY, Thistlethwaite PA, Wang J, Makino A, Prakash YS, Pabelick CM, Yuan JX.   +21 more
europepmc   +1 more source

The interplay between mitochondria and store-operated Ca²⁺ entry: Emerging insights into cardiac diseases. [PDF]

J Cell Mol Med, 2021
Nan J, Li J, Lin Y, Saif Ur Rahman M, Li Z, Zhu L.   +5 more
europepmc   +1 more source

MAM‐Localized MANF Counteracts Microinflammatory Stress to Attenuate Mitochondrial Dysfunction and Cataractogenesis in High Myopia

Advanced Science, EarlyView.
Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu, Hao Li, Ching Kang, Dongling Guo, Shuyu Liu, Jiaqi Meng, Zhiqian Huang, Yu Du, Xiangjia Zhu   +8 more
wiley   +1 more source

Side-by-side comparison of published small molecule inhibitors against thapsigargin-induced store-operated Ca2+ entry in HEK293 cells. [PDF]

PLoS One
Norman K, Hemmings KE, Shawer H, Appleby HL, Burnett AJ, Hamzah N, Gosain R, Woodhouse EM, Beech DJ, Foster R, Bailey MA.   +10 more
europepmc   +1 more source

Role of Store-Operated Ca²⁺ Entry in the Pulmonary Vascular Remodeling Occurring in Pulmonary Arterial Hypertension. [PDF]

Biomolecules, 2021
Masson B, Montani D, Humbert M, Capuano V, Antigny F.   +4 more
europepmc   +1 more source

Deep Learning Network‐Tailored Microenvironment Matching of 4D Bioprinting Bioactive Scaffolds for Bone Regeneration

Advanced Science, EarlyView.
A DLN dataset was built to analyze MABS composition versus in vitro/in vivo osteogenesis and angiogenesis. An MLP neural network, taking BG morphological parameters as input, extracts bioactive features from these datasets. A rabbit tibial defect model then validates 4D‐printed MABS for adaptability and bone regeneration in critical defects.
Xiongjie Liang, Yuechi Zhang, Weifeng Hu, Shiyan Lv, Fan Jia, Yan Zhang, Feng Wu, Changjiang Yang, Guanqi Zhen, Jinglong Yan, Xu Cui, Wei Zhao, Guanghua Chen   +12 more
wiley   +1 more source

Store-Operated Ca²⁺ Entry Contributes to Piezo1-Induced Ca²⁺ Increase in Human Endometrial Stem Cells. [PDF]

Int J Mol Sci, 2022
Chubinskiy-Nadezhdin V, Semenova S, Vasileva V, Shatrova A, Pugovkina N, Negulyaev Y.   +5 more
europepmc   +1 more source

Calcineurin‐Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in Candida Glabrata

Advanced Science, EarlyView.
Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su, Yi Li, Meng Xiao, Dan Guo, David S. Perlin, Erika Shor, Yingchun Xu, Yingxing Li   +7 more
wiley   +1 more source