Results 181 to 190 of about 12,900 (288)

2-Methoxyestradiol-3,17-O,O-bis-sulfamate inhibits store-operated Ca²⁺ entry in T lymphocytes and prevents experimental autoimmune encephalomyelitis. [PDF]

Biochim Biophys Acta Mol Cell Res, 2023
Hosang L, Löhndorf A, Dohle W, Rosche A, Marry S, Diercks BP, Müller-Kirschbaum LC, Flügel LT, Potter BVL, Odoardi F, Guse AH, Flügel A.   +11 more
europepmc   +1 more source

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Advanced Science, EarlyView.
Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl, David Holubek, Klaus Speck, Raphael Wildermuth, Franz‐Lucas Haut, Stephan Permann, Immanuel Plangger, Christian Steinborn, Zhigang Rao, Danilo D'Avino, Ida Cerqua, Julia Stadler, Fiorentina Roviezzo, Peter Schlenke, Anita Siller, Harald Schennach, Solveigh C. Koeberle, Eva‐Maria Pferschy‐Wenzig, Antonietta Rossi, Thomas Magauer, Andreas Koeberle   +20 more
wiley   +1 more source

Neutrophil store-operated Ca²⁺ entry: A correctable biomarker of cystic fibrosis lung disease progression. [PDF]

J Cyst Fibros
Wrennall JA, Biggart MG, Bengtson CD, Sassano MF, Tarran R.   +4 more
europepmc   +1 more source

Exercise Reduces Airway Smooth Muscle Contraction in Asthmatic Rats via Inhibition of IL-4 Secretion and Store-Operated Ca²⁺ Entry Pathway. [PDF]

Allergy Asthma Immunol Res, 2023
Huang JH, Gao HW, Gao DD, Yang WY, Zhao MK, Shen B, Hu M.   +6 more
europepmc   +1 more source

B Cells are Activated via a Nanoporous Interface that Stabilizes Microvilli and Engages Mechanosensitive Ion Channels

Advanced Science, EarlyView.
B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu, Willi Weber, Nadine Strempel, Asya Polat, Enrico Klotzsch   +4 more
wiley   +1 more source

Ca2+ Depletion in the ER Causes Store-Operated Ca2+ Entry via the TRPC6 Channel in Mouse Brown Adipocytes. [PDF]

Physiol Res
Hayato R, Matsumoto T, Higure Y.
europepmc   +1 more source

Ion‐Driven Regulation of Ca2+ Flow by Ti/Zn Composite Activates ERK/MAPK Signaling and Maintains Mitochondrial Homeostasis to Promote Macrophage‐Mediated Bone Regeneration

Advanced Science, EarlyView.
A 3D‐printed interpenetrating Ti/Zn composite enables sustained Zn2+ release to regulate intracellular Ca2+ redistribution, preserve mitochondrial homeostasis, activate ERK/MAPK signaling, and promote M2 macrophage polarization, thereby enhancing osteoimmune‐mediated bone regeneration and peri‐implant osseointegration.
Wanyi Huang, Qiyue Zhang, Yueyang Qiu, Haocheng Suo, Zengqian Liu, Bing Bai, Qiang Wang, Qing Zhou   +7 more
wiley   +1 more source

Store-Operated Ca²⁺ Entry Is Up-Regulated in Tumour-Infiltrating Lymphocytes from Metastatic Colorectal Cancer Patients. [PDF]

Cancers (Basel), 2022
Faris P, Rumolo A, Tapella L, Tanzi M, Metallo A, Conca F, Negri S, Lefkimmiatis K, Pedrazzoli P, Lim D, Montagna D, Moccia F.   +11 more
europepmc   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Latrophilin-1-Mediated G_αq Signaling, Store-Operated Ca²⁺ Entry, and Ca_V2.1 Activation Control Spontaneous Exocytosis at the Mouse Neuromuscular Junction. [PDF]

Cells
Petitto E, Meunier FA, Fidalgo S, Colasante C, Blackburn JK, Ribchester RR, Ushkaryov YA.   +6 more
europepmc   +1 more source