Results 171 to 180 of about 12,900 (288)

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Orai1-mediated store-operated Ca²⁺ entry promotes cervical cancer progression through IL-6 signaling. [PDF]

Front Mol Biosci, 2022
Pan Y, Huang J, Liu K, Xie C, Chen H, Guo Z, Guo S, Chen Y.   +7 more
europepmc   +1 more source

Unraveling Hierarchical B‐Site Ordering: Mechanism of Microwave Dielectric Enhancement in Complex Perovskite Oxide Ceramics

Advanced Science, EarlyView.
This study maps out the hierarchical ordering in 1:2 B‐site complex perovskite ceramics using a comprehensive multiscale characterization route. It turns out that intradomain strain, oxygen vacancies, and Mg disorder within the ordered domains act as strong phonon scatterers.
Qingqiao Fu, Hui Gu, Hanbin Gao, Pianpian Ma, Xiangming Chen, Juanjuan Xing, Qiang Zheng   +6 more
wiley   +1 more source

Alternatively spliced STIM2.3 is an evolutionarily late store-operated Ca2+ entry regulator expressed in brain. [PDF]

J Cell Sci
Poth V, Do HTT, Jarzembowski L, Laius KL, Förderer K, Tschernig T, Robertson HB, Alansary D, Shaebani R, Helms V, Niemeyer BA.   +10 more
europepmc   +1 more source

Antioxidants restore store-operated Ca²⁺ entry in patient-iPSC-derived myotubes with tubular aggregate myopathy-associated Ile484ArgfsX21 STIM1 mutation via upregulation of binding immunoglobulin protein. [PDF]

FASEB Bioadv, 2023
Sakai-Takemura F, Saito F, Nogami K, Maruyama Y, Elhussieny A, Matsumura K, Takeda S, Aoki Y, Miyagoe-Suzuki Y.   +8 more
europepmc   +1 more source

Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States

Advanced Science, EarlyView.
Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton, Carrillo Paola Gonzalez, Luay Almassalha, Wing Shun Li, Ruyi Gong, Nicolas Acosta, I Chae Ye, Jane Frederick, Christopher Hogg, Saira John, J. A. Gareth Williams, Rikkert J. Nap, Igal Szleifer, Vadim Backman   +13 more
wiley   +1 more source

STIM/Orai-Mediated Store-Operated Ca²⁺ Entry in the Pathogenesis of Fibrosis: Mechanisms and Therapeutic Opportunities. [PDF]

Cells
Yi Y, Uddin MN, Killeen K, Gill DL, Zhou Y.   +4 more
europepmc   +1 more source

Store-operated Ca²⁺ entry regulatory factor alters murine metabolic state in an age-dependent manner via hypothalamic pathways. [PDF]

PNAS Nexus, 2023
Gataulin D, Kuperman Y, Tsoory M, Biton IE, Nataniel T, Palty R, Karbat I, Meshcheriakova A, Reuveny E.   +8 more
europepmc   +1 more source

Miro1 Protects Against Acute Kidney Injury Through Modulating Mitochondrial Homeostasis via Interaction With Sirt6

Advanced Science, EarlyView.
Ischemia‐reperfusion reduces Sirt6 activity, thereby increasing Miro1 acetylation. Hyperacetylated Miro1 exhibits perinuclear distribution and degradation, thereby inducing mitochondrial dysfunction and promoting apoptosis in renal tubular epithelial cells. This pathway reveals a mechanistic link between Sirt6‐mediated deacetylation and Miro1 stability
Lin Wu, Qing Li, Yiyang Xu, Zitao Wang, Hua Shu, Yangfan Wu, Fang Lu, Zhimin Huang, Bo Zhang, Hongwei Liang, Changying Xing, Huijuan Mao, Yanggang Yuan   +12 more
wiley   +1 more source

Role of store-operated Ca²⁺ entry and STIM2 in retinal neurodegeneration during glaucoma. [PDF]

Front Aging Neurosci
Baranykova S.
europepmc   +1 more source