Results 251 to 260 of about 2,808,407 (277)

Role of TRPC Channels in Store-Operated Calcium Entry

2016
Store-operated calcium entry (SOCE) is a ubiquitous Ca(2+) entry pathway that is activated in response to depletion of Ca(2+) stores within the endoplasmic reticulum (ER) and contributes to the control of various physiological functions in a wide variety of cell types.
Hwei Ling, Ong, Lorena Brito, de Souza, Indu S, Ambudkar   +2 more
openaire   +2 more sources

Mitochondria's Role in Store‐Operated Calcium Entry

The FASEB Journal, 2008
Inflammatory agonists deplete calcium from the endoplasmic reticulum and activate calcium entry in a process referred to as store‐operated calcium (SOC). Calcium store depletion can be distinctly measured from calcium entry using a recalcification protocol, in which store depletion is activated in the presence of low extracellular calcium.
Christina Jean Barry, Donna L. Cioffi, Troy Stevens   +2 more
openaire   +1 more source

Molecular Basis and Regulation of Store-Operated Calcium Entry

2019
Store-operated Ca2+ entry (SOCE) is a ubiquitous mechanism for Ca2+ influx in mammalian cells with important physiological implications. Since the discovery of SOCE more than three decades ago, the mechanism that communicates the information about the amount of Ca2+ accumulated in the intracellular Ca2+ stores to the plasma membrane channels and the ...
Jose J, Lopez, Isaac, Jardin, Letizia, Albarrán, Jose, Sanchez-Collado, Carlos, Cantonero, Gines M, Salido, Tarik, Smani, Juan A, Rosado   +7 more
openaire   +2 more sources

Store-Operated Calcium Entry Channels

2017
Store-operated Ca2+ entry (SOCE) channels mediate Ca2+ influx from the extracellular milieu into the cytosol to regulate a myriad of cellular functions. The Ca2+-release activated Ca2+ current has been well characterized in non-excitable cells such as immune cells.
openaire   +1 more source

"TRPping" the Switch for Store-Operated Calcium Entry

Science Signaling, 2000
Agents that signal by increasing the intracellular concentration of free Ca 2+ often cause both release of Ca 2+ from intracellular stores and influx of Ca 2+ through channels in the plasma membrane.
openaire   +2 more sources

Pharmacology of Store-Operated Calcium Entry Channels

2017
In general, calcium signaling in non-excitable cells is primarily initiated by the activation of surface membrane receptors coupled to phospholipase C (PLC) and stimulates a calcium signaling process that is complex both spatially and temporally, involving the interplay of calcium channels and calcium pumps [1].
Gary S. Bird, James W. Putney
openaire   +1 more source

Is there a role for store-operated calcium entry in vasoconstriction?

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2001
transitions in cytosolic calcium concentration ([Ca2+]i) represent an important physiological signal in cells ([1][1]). A rise in smooth muscle cell [Ca2+]i activates myosin light chain kinase, which promotes myosin light chain phosphorylation and actomyosin interaction.
openaire   +2 more sources

Insights into the Regulation of Store-operated Calcium Entry

2015
Calcium (Ca2+) ions serve a crucial role in numerous intracellular signaling pathways, controlling physiological functions as diverse as cell proliferation, immune system function, and muscular contraction. As such, the cell has evolved many different mechanisms to precisely control the movement of Ca2+ ions into and out of various cellular ...
openaire   +1 more source

Orai3 Regulates Pancreatic Cancer Metastasis by Encoding a Functional Store Operated Calcium Entry Channel

Cancers, 2021
Jyoti Tanwar, Rajender K Motiani, Suman Saurav   +2 more
exaly  

Rectifying Attenuated Store-Operated Calcium Entry as a Therapeutic Approach for Alzheimer’s Disease

Current Alzheimer Research, 2021
Su Chengfu, Zhou Zhu, Jia Liu
exaly