Results 1 to 10 of about 70,186 (142)

Hypoxia-induced mitochondrial stress granules

Cell Death and Disease, 2023
Perturbations of mitochondrial proteostasis have been associated with aging, neurodegenerative diseases, and recently with hypoxic injury. While examining hypoxia-induced mitochondrial protein aggregation in C.
Chun-Ling Sun, Marc Van Gilst, C. Michael Crowder   +2 more
doaj   +3 more sources

Translation landscape of stress granules. [PDF]

Sci Adv
Abstract Stress granules, cytoplasmic assemblies of RNA-binding proteins and mRNAs formed during cellular stress, are implicated in translational control. However, their exact functions remain elusive. Here, we employed cryogenic correlative light and electron microscopy to visualize stress granules in their native environment and reconstructed
Wu Y, Wang X, Meng L, Liao Z, Ji W, Zhang P, Lin J, Guo Q.   +7 more
europepmc   +3 more sources

NEDDylation promotes stress granule assembly [PDF]

Nature Communications, 2016
Stress granules that form in response to stress contain translationally stalled mRNPs and play important roles in cellular homeostasis. Here the authors implicate SRSF3 neddylation as an important factor in the formation of stress granules in response to
Aravinth Kumar Jayabalan, Anthony Sanchez, Ra Young Park, Sang Pil Yoon, Gum-Yong Kang, Je-Hyun Baek, Paul Anderson, Younghoon Kee, Takbum Ohn   +8 more
doaj   +5 more sources

Chronic stress antagonizes formation of stress granules. [PDF]

iScience
AbstractChronic stress mediates cellular changes that can contribute to human disease. However, fluctuations in RNA metabolism caused by chronic stress have been largely neglected in the field. Stress granules (SGs) are cytoplasmic ribonucleoprotein condensates formed in response to stress-induced inhibition of mRNA translation and polysome disassembly.
Adachi Y, Williams AM, Masuda M, Taketani Y, Anderson PJ, Ivanov P.   +5 more
europepmc   +3 more sources

Rim4-seeded stress granules connect temperature sensing to meiotic regulation [PDF]

Nature Communications
Meiosis is more vulnerable to heat than mitosis in many species including humans. In Saccharomyces cerevisiae, we discovered that stress granule formation halts meiosis at high temperatures. Meiotic stress granules appear at lower temperatures (33–42 °C)
Rudian Zhang, Shunjin Li, Wenzhi Feng, Suhong Qian, Akshay John Chellappa, Fei Wang   +5 more
doaj   +2 more sources

Stress granules: Guardians of cellular health and triggers of disease [PDF]

Neural Regeneration Research
Stress granules are membraneless organelles that serve as a protective cellular response to external stressors by sequestering non-translating messenger RNAs (mRNAs) and regulating protein synthesis.
Meghal Desai, Keya Gulati, Manasi Agrawal, Shruti Ghumra, Pabitra K. Sahoo   +4 more
doaj   +2 more sources

Stress granules regulate paraspeckles: RNP granule continuum at work [PDF]

Cell Stress, 2019
Eukaryotic cells contain several types of RNA-protein membraneless macro-complexes – ribonucleoprotein (RNP) granules that form by liquid-liquid phase separation.
Haiyan An, Tatyana A. Shelkovnikova
doaj   +3 more sources

Functional amyloid protein FXR1 is recruited into neuronal stress granules [PDF]

Prion
The FXR1 protein regulates the stability and translation of a number of RNA molecules and plays an important role in the regulation of cellular processes under normal conditions and stress.
Anna A. Valina, Tatyana A. Belashova, Anastasia K. Yuzman, Sergey P. Zadorsky, Evgeniy I. Sysoev, Vladimir A. Mitkevich, Alexander A. Makarov, Alexey P. Galkin   +7 more
doaj   +2 more sources

Cellular Stress Induces Nucleocytoplasmic Transport Deficits Independent of Stress Granules

Biomedicines, 2022
Stress granules are non-membrane bound granules temporarily forming in the cytoplasm in response to stress. Proteins of the nucleocytoplasmic transport machinery were found in these stress granules and it was suggested that stress granules contribute to ...
Joni Vanneste, Thomas Vercruysse, Steven Boeynaems, Philip Van Damme, Dirk Daelemans, Ludo Van Den Bosch   +5 more
doaj   +1 more source

Mechanism and effect of stress granule formation in cancer and its potential roles in breast cancer therapy

Genes and Diseases, 2022
Stress granules are non-membranous cytoplasmic foci induced by various stress conditions. It is a protective strategy used by cells to suppress overall translation during stress. In cancer cells, it was thought that the formation of stress granules could
Taobo Hu, Wei Hou, Enhua Xiao, Mengping Long   +3 more
doaj   +1 more source