Results 1 to 10 of about 4,058,220 (323)

Canonical cellular stress granules are required for arsenite-induced necroptosis mediated by Z-DNA–binding protein 1 [PDF]

Science Signaling, 2023
Cellular stress granules arise in cells subjected to stress and promote cell survival. A cellular protein that localizes to stress granules is Z-DNA–binding protein 1 (ZBP1), which plays a major role in necroptosis, a programmed cell death pathway ...
Mateusz Szczerba, Brian P. Johnson, Francesco Acciai, Carolina Gogerty, Megan McCaughan, Jacqueline Williams, Karen V. Kibler, Bertram L. Jacobs   +7 more
openalex   +2 more sources

Stress granules in the spinal muscular atrophy and amyotrophic lateral sclerosis: The correlation and promising therapy

Neurobiology of Disease, 2022
Increasing genetic and biochemical evidence has broadened our view of the pathomechanisms that lead to Spinal muscular atrophy (SMA) and Amyotrophic lateral sclerosis (ALS), two fatal neurodegenerative diseases with similar symptoms and causes.
LiDan Hu, Shanshan Mao, Li Lin, Guannan Bai, Bingjie Liu, Jianhua Mao   +5 more
doaj   +2 more sources

N4-acetylcytidine (ac4C) promotes mRNA localization to stress granules

EMBO Reports
Stress granules are an integral part of the stress response that are formed from non-translating mRNAs aggregated with proteins. While much is known about stress granules, the factors that drive their mRNA localization are incompletely described ...
Pavel Kudrin, Ankita Singh, David Meierhofer, Anna Kuśnierczyk, Ulf Andersson Vang Ørom   +4 more
doaj   +2 more sources

Small-molecule dissolution of stress granules by redox modulation benefits ALS models. [PDF]

Nat Chem Biol
Neurodegenerative diseases, such as amyotrophic lateral sclerosis, are often associated with mutations in stress granule proteins. Aberrant stress granule condensate formation is associated with disease, making it a potential target for pharmacological ...
Uechi H, Sridharan S, Nijssen J, Bilstein J, Iglesias-Artola JM, Kishigami S, Casablancas-Antras V, Poser I, Martinez EJ, Boczek E, Wagner M, Tomschke N, de Jesus Domingues AM, Pal A, Doeleman T, Kour S, Anderson EN, Stein F, Lee HO, Zhang X, Fritsch AW, Jahnel M, Fürsch J, Murthy AC, Alberti S, Bickle M, Fawzi NL, Nadler A, David DC, Pandey UB, Hermann A, Stengel F, Davis BG, Baldwin AJ, Savitski MM, Hyman AA, Wheeler RJ.   +36 more
europepmc   +2 more sources

NS1 binding protein regulates stress granule dynamics and clearance by inhibiting p62 ubiquitination [PDF]

Nature Communications
The NS1 binding protein, known for interacting with the influenza A virus protein, is involved in RNA processing, cancer, and nerve cell growth regulation. However, its role in stress response independent of viral infections remains unclear.
Pureum Jeon, Hyun-Ji Ham, Haneul Choi, Semin Park, Jae-Woo Jang, Sang-Won Park, Dong-Hyung Cho, Hyun-Jeong Lee, Hyun Kyu Song, Masaaki Komatsu, Dohyun Han, Deok-Jin Jang, Jin-A Lee   +12 more
doaj   +2 more sources

Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology

eLife, 2019
Stress granules (SGs) are non-membrane-bound RNA-protein granules that assemble through phase separation in response to cellular stress. Disturbances in SG dynamics have been implicated as a primary driver of neurodegenerative diseases, including ...
Peipei Zhang, Baochang Fan, Peiguo Yang, Jamshid Temirov, James Messing, Hong Joo Kim, J. Paul Taylor   +6 more
openalex   +2 more sources

Rim4-seeded stress granules connect temperature sensing to meiotic regulation [PDF]

Nature Communications
Meiosis is more vulnerable to heat than mitosis in many species including humans. In Saccharomyces cerevisiae, we discovered that stress granule formation halts meiosis at high temperatures. Meiotic stress granules appear at lower temperatures (33–42 °C)
Rudian Zhang, Shunjin Li, Wenzhi Feng, Suhong Qian, Akshay John Chellappa, Fei Wang   +5 more
doaj   +2 more sources

Stress granules: Guardians of cellular health and triggers of disease [PDF]

Neural Regeneration Research
Stress granules are membraneless organelles that serve as a protective cellular response to external stressors by sequestering non-translating messenger RNAs (mRNAs) and regulating protein synthesis.
Meghal Desai, Keya Gulati, Manasi Agrawal, Shruti Ghumra, Pabitra K. Sahoo   +4 more
doaj   +2 more sources

Functional amyloid protein FXR1 is recruited into neuronal stress granules [PDF]

Prion
The FXR1 protein regulates the stability and translation of a number of RNA molecules and plays an important role in the regulation of cellular processes under normal conditions and stress.
Anna A. Valina, Tatyana A. Belashova, Anastasia K. Yuzman, Sergey P. Zadorsky, Evgeniy I. Sysoev, Vladimir A. Mitkevich, Alexander A. Makarov, Alexey P. Galkin   +7 more
doaj   +2 more sources

Dance with the Devil: Stress Granules and Signaling in Antiviral Responses

Viruses, 2020
Cells have evolved highly specialized sentinels that detect viral infection and elicit an antiviral response. Among these, the stress-sensing protein kinase R, which is activated by double-stranded RNA, mediates suppression of the host translation ...
Nina Eiermann, Katharina Haneke, Zhaozhi Sun, Georg Stoecklin, Alessia Ruggieri   +4 more
doaj   +2 more sources