Results 71 to 80 of about 284,887 (285)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

A Dynamics-Based Adaptive String Stable Controller for Connected Heavy Road Vehicle Platoon Safety

IEEE Access, 2020
This article presents a string stable controller for the autonomous operation of a platoon of Heavy Commercial Road Vehicles (HCRVs) in a connected environment.
K. B. Devika, G. Rohith, Venkata Ramani Shreya Yellapantula, Shankar C. Subramanian   +3 more
doaj   +1 more source

Cosmic Strings Stabilized by Quantum Fluctuations [PDF]

Russian Physics Journal, 2017
We compute fermion quantum corrections to the energy of cosmic strings. A number of rather technical tools is needed to formulate this correction and we employ isospin and gauge invariance to verify consistency of these tools. These corrections must also be included when computing the energy of strings that are charged by populating fermion bound ...
openaire   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Investigating Off-shell Stability of Anti-de Sitter Space in String Theory [PDF]

, 2008
We propose an investigation of stability of vacua in string theory by studying their stability with respect to a (suitable) world-sheet renormalization group (RG) flow.
Adams A, Adams R A, Anderson M T, Andersson L Moncrief V, Bakas I Sourdis C, Bourguignon J-P, Cao H-D, Cao H-D, Cao H-D Hamilton R Ilmanen T, Chow B, Dai X Wang X Wei G, Feldman M Ilmanen T Ni L, Fischer A E, Giveon A, Gubser S S, Guenther C, Guenther C, Gutperle M, Headrick M, Headrick M, Holzegel G, Ishibashi A, Knopf D, Morgan J, Okawa Y, Perelman G, Perelman G, Perelman G, Schnuerer O, Sesum N, Taylor M E, Topping P, V Suneeta, Wald R M   +33 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Solving the Hierarchy Problem without Supersymmetry or Extra Dimensions: An Alternative Approach [PDF]

, 2001
In this paper, we propose a possible new approach towards solving the gauge hierarchy problem without supersymmetry and without extra spacetime dimensions.
Alvarez, Alvarez-Gaumé, Alvarez-Gaumé, Angelantonj, Angelantonj, Angelantonj, Antoniadis, Antoniadis, Antoniadis, Antoniadis, Antoniadis, Antoniadis, Antoniadis, Antoniadis, Antoniadis, Arkani-Hamed, Arkani-Hamed, Arkani-Hamed, Arkani-Hamed, Arnowitt, Bachas, Balog, Banks, Banks, Barbieri, Benakli, Bergman, Bergman, Bianchi, Bianchi, Binetruy, Binetruy, Binetruy, Blum, Blum, Blumenhagen, Blumenhagen, Bousso, Burgess, Burgess, Carroll, Chen, Cline, Cohen, Collins, Contino, Csaki, Csaki, Csaki, Cudell, Dai, de Alwis, Delgado, Dienes, Dienes, Dienes, Dienes, Dienes, Dienes, Dienes, Dienes, Dienes, Dienes, Dienes, Dienes, Dienes, Dine, Dixon, Dvali, Ewens, Faraggi, Feng, Ferrara, Ferrara, Ferrara, Ferrara, Flanagan, Forste, Frampton, Frampton, Frampton, Frampton, Gaberdiel, Gaillard, Gannon, Ghilencea, Gimon, Ginsparg, Green, Haber, Hardy, Harvey, Hořava, Hořava, Hořava, Ibáñez, Ibáñez, Itoyama, Jack, Kachru, Kachru, Kachru, Kachru, Kachru, Kakushadze, Kakushadze, Kakushadze, Kakushadze, Kakushadze, Kane, Kani, Kawai, Kehagias, Keith R Dienes, Kim, Krause, Krause, Kutasov, Lahanas, Lopez, Lopez, Lykken, Lykken, Martin, Moore, Moore, Niarchos, Nilles, Polchinski, Polchinski, Pradisi, Quevedo, Quevedo, Randall, Rohm, Rubakov, Russo, Sagnotti, Scherk, Schmidhuber, Schmidhuber, Shah, Shiu, Shiu, Spalinski, Taylor, Tetradis, Thomas, Tseytlin, Tye, Verlinde, Weinberg, Witten, Witten   +153 more
core   +2 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Black string in massive gravity

Nuclear Physics B, 2021
We will analyze a black string in dRGT massive theory of gravity. Considering different approaches, we will study the critical behavior, phase transition and thermal stability for such a black string solution.
Seyed Hossein Hendi, Hayede Zarei, Mir Faizal, Behnam Pourhassan, Zahra Armanfard   +4 more
doaj   +1 more source

Stability of string defects in models of non-Abelian symmetry breaking [PDF]

, 1998
In this paper we describe a new type of topological defect, called a homilia string, which is stabilized via interactions with the string network. Using analytical and numerical techniques, we investigate the stability and dynamics of homilia strings ...
A. Davis, A. Everett, A. Stebbins, A. Vilenkin, A. Vilenkin, E. Leader, E. Myers, E. Shellard, E. Witten, F. Bouchet, F. Klinkhamer, G. ’t Hooft, J. Preskill, L. Perivolaropoulos, M. Axenides, M. Hindmarsh, M. Thatcher, Marcus J. Thatcher, Michael J. Morgan, N. Kaiser, P. Saffin, R. Brandenberger, R. Davis, R. Davis, R. Scherrer, T. Kibble, T. Kibble, T. Vachaspati, T. Vachaspati, W. Hiscock   +29 more
core   +2 more sources