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Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1) [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2012
Calcium influx through the Ca 2+ release-activated Ca 2+ (CRAC) channel is an essential process in many types of cells. Upon store depletion, the calcium sensor in the endoplasmic reticulum, STIM1, activates Orai1, a CRAC channel in the plasma membrane.
Xiangyu Cai, Yuequan Shen, Xue Yang
exaly   +3 more sources

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Role of Stromal Interaction Molecule 1 in Arteriogenesis

The FASEB Journal, 2020
Introduction Arteriogenesis is a vital process for maintaining blood supply in the event of abrupt obstruction of perfusion such as cardiac ischemia. Here, we sought to determine whether stromal‐interaction molecule 1 (STIM1) is a key molecular mechanism involved in arteriogenesis.
Michaela Frost, Souad Belmadani, Khalid Matrougui   +2 more
openaire   +1 more source

Does stromal interaction molecule-1 have five senses?

Cell Calcium, 2019
A single calcium (Ca2+) binding site within the canonical EF-hand loop was thought to govern the stromal interaction molecule-1 (STIM1) structural changes that lead to activation of Orai1 Ca2+ channels. Recent work by Gudlur et al., published in Nat Commun [9(1):4536], suggests that the STIM1 endoplasmic reticulum (ER) luminal domain has ∼5 additional ...
Peter B Stathopulos, Mitsuhiko Ikura
exaly   +3 more sources

Stromal interaction molecule 1 is required for neonatal testicular development in mice

Biochemical and Biophysical Research Communications, 2018
Stromal interaction molecule 1 (STIM1) is a transmembrane endoplasmic reticulum protein, and it serves as a Ca2+ sensor and activator of store-operated Ca2+ entry (SOCE). We have previously identified STIM1 in the proteome profile of mice neonatal testes, revealing STIM1 to be associated with neonatal testicular development.
Cong Shen, Ke Zhang, Jun Yu, Yueshuai Guo, Tingting Gao, Yuanyuan Liu, Xi Zhang, Xia Chen, Yi Yu, Hongbo Cheng, Aiyan Zheng, Hong Li, Xiaoyan Huang, Xufeng Ding, Bo Zheng   +14 more
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Interactions between the G Protein‐coupled Estrogen Receptor and the Stromal Interaction Molecule 1

The FASEB Journal, 2017
The G protein‐coupled estrogen receptor (GPER/GPR30) participates in various Ca 2+ ‐dependent cellular functions, yet its direct effects and mechanisms on components of Ca 2+ signaling machinery are incompletely understood. Store‐operated Ca
Kim Tran, Lara E Terry, Briana Gebert‐Oberle, Jennifer Giles, Mark VerMeer   +4 more
openaire   +1 more source

Platelet secretion defect in a patient with stromal interaction molecule 1 deficiency

Blood, 2013
To the editor: During the last few years, the Ca2+ sensor stromal interaction molecule 1 (STIM1) and the channel protein Orai1 have emerged as critical components of store operated Ca2+ entry in platelets.[1][1] In human platelets, both proteins were detected in dense granules and lysosome ...
Nakamura, Lea, Sandrock, Kirstin, Speckmann, Carsten, Vraetz, Thomas, Buhrlen, M., Ehl, Stephan, Heemskerk, Johan W. M., Zieger, Barbara   +7 more
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Functional role of stromal interaction molecule 1 (STIM1) in vascular smooth muscle cells

Biochemical and Biophysical Research Communications, 2007
We investigated the functional role of STIM1, a Ca(2+) sensor in the endoplasmic reticulum (ER) that regulates store-operated Ca(2+) entry (SOCE), in vascular smooth muscle cells (VSMCs). STIM1 was mainly localized at the ER and plasma membrane. The knockdown of STIM1 expression by small interfering (si) RNA drastically decreased SOCE.
Yoichiro, Takahashi, Hiroyuki, Watanabe, Manabu, Murakami, Kyoichi, Ono, Yoshiko, Munehisa, Takashi, Koyama, Kiyoshi, Nobori, Toshihiko, Iijima, Hiroshi, Ito   +8 more
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Effects of stromal interaction molecule 1 or Orai1 overexpression on the associated proteins and permeability of podocytes

Nephrology, 2016
AbstractAimThe present study was conducted to determine whether two important signalling molecules of store‐operated channel (SOC), stromal interaction molecule 1 (STIM1) and Orai1, were involved in glomerular podocyte injury. We explored the effects of STIM1/Orai1 overexpression on podocyte associated proteins and cell permeability.MethodsThe ...
Li, Miao, Dongyue, Wei, Yuanyuan, Zhang, Jiansheng, Liu, Siguang, Lu, Aihua, Zhang, Songming, Huang   +6 more
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Abstract 19844: Stromal Interaction Molecule 1 is Essential for the Maintenance of Cardiac Metabolism

Circulation, 2015
The ER/SR Ca 2+ sensor, Stromal Interaction molecule 1 (STIM1), a key regulator of store-operated calcium entry is expressed in cardiomyocytes and has been implicated in regulating hypertrophic signaling.
Helen E Collins, Betty M Pat, Silvio H Litovsky, Martin E Young, John C Chatham   +4 more
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Abstract 447: Essential Role of Stromal Interaction Molecule 1 in Heart Failure

Circulation Research, 2016
Background: Stromal interacting molecule 1 (STIM1) is a calcium sensor in the endoplasmic reticulum (ER). We previously reported that STIM1 plays opposing roles in vascular smooth muscle cells (SMC) vs. endothelial cell in the regulation of vascular reactivity.
Vishal R Mali, Maha Ali, Samuel Haddox, Mohamed Trebak, Khalid Matrougui   +4 more
openaire   +1 more source