Results 231 to 240 of about 32,791,583 (267)

Making Prodrugs Stick Around: Engineering Protease-Activated Tumor Retention. [PDF]

ACS Cent Sci
Kryštůfek R, Konvalinka J.
europepmc   +1 more source

Polystyrene Nanoplastics Drive β‐Cell Dedifferentiation Through Dendritic Cell‐Intrinsic MHC‐I‐Dependent Inflammatory Crosstalk

Advanced Science, EarlyView.
Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao, Yuqing Song, Fang Yang, Menghui Guo, Libin Jiang, Xiaoyue Quan, Wei Wei, Xinyang Wang, Tianshu Han, Mingyuan Liu, Wenbo Jiang   +10 more
wiley   +1 more source

Integrin α5β1 in pancreatic ductal adenocarcinoma: Tumour‒stroma crosstalk, hypoxia and therapeutic targeting. [PDF]

Clin Transl Med
Ma C, Wang Y, Li Y.
europepmc   +1 more source

Single‐Cell Profiling Reveals a Protective WNT5A‐ATF3‐FOSB Signaling Axis in Hair Follicle Stem Cells During Androgenetic Alopecia

Advanced Science, EarlyView.
Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo, Ke Fang, Changjiang Zhao, Jiachao Xiong, Yuan Zhu, Mingyang Lu, He Yan, Zihan Li, Baojin Wu, Hua Jiang, Yufei Li   +10 more
wiley   +1 more source

The Transformation of the Microenvironment: From Observer to Coordinator in Monoclonal Gammopathy of Undetermined Significance (MGUS) to Myeloma Development. [PDF]

Hematol Oncol
Abdelgawwad El-Sehrawy AAM, Shnoudeh AJ, Yuldashev I, Jalilova D, Alimova Z, Panigrahi R, Hashem RM, Bainsal N.   +7 more
europepmc   +1 more source

Recapitulating In Vivo Pharmacokinetics and Size‐Dependent Nanomedicine Delivery in a Microfluidic Platform

Advanced Science, EarlyView.
A microfluidic tumor platform integrates pharmacokinetic flow control, vascular‐like barriers, and 3D tumor spheroids to emulate in vivo drug exposure. The system reproduces dynamic concentration–time profiles and enables size‐dependent nanoparticle transport and efficacy evaluation, providing a predictive framework for assessing nanomedicine ...
Su Jeong Kang, Moon Sup Yoon, Jae Min Lee, Min Jeong Jo, Chae Eun Jin, Dae Hwan Shin   +5 more
wiley   +1 more source

Single-cell analysis of the synovium and infrapatellar fat pad identifies key pathogenic genes and drug targets in osteoarthritis. [PDF]

Int J Clin Exp Pathol
Zhu Y, Zhu Y, Tong P, Cheng F.
europepmc   +1 more source

Ferroptosis in gastrointestinal stromal tumors. [PDF]

J Gastrointest Oncol
Jenke R, Aigner A.
europepmc   +1 more source

The PROM1⁺SMAD5⁺ Tumor-Initiating Subpopulation Shapes Premetastatic Niches through Spatial Multi-Omics Landscapes in HER2-Positive Breast Cancer. [PDF]

Cancer Commun (Lond)
Yin H, Wang W, Ge J, Fan G, Shi J, Tian Y, Kong D, Zhang F, Wei J, Zhan H, Xu Z, Ge J, Wang S, Zhang Z, Zheng Y, Zhu Z, Zi Q, Yao X, Ding Y, Song B, Li R, Fan L, Yin H, Jiang Y, Zhang S, Fu X, Wang J, Zhou Y, Xue H, Qiu Y, Ge L, Yang Y, Jin Y, Lou B, Ding S, Zhang T, Wei D, Zhu L.   +37 more
europepmc   +1 more source

An S-glutathiomimetic Provides Structural Insights into Stromal Interaction Molecule-1 Regulation

Journal of Molecular Biology, 2022
Stromal interaction molecule 1 (STIM1) is an endo/sarcoplasmic reticulum (ER/SR) calcium (Ca2+) sensing protein that regulates store-operated calcium entry (SOCE). In SOCE, STIM1 activates Orai1-composed Ca2+ channels in the plasma membrane (PM) after ER stored Ca2+ depletion. S-Glutathionylation of STIM1 at Cys56 evokes constitutive SOCE in DT40 cells;
Peter B Stathopulos, Matthew J Novello, Christian Sirko   +2 more
exaly   +3 more sources