Results 1 to 10 of about 7,622 (205)

Succinylation heterogeneity in lung adenocarcinoma: from prognostic model to KLK6-driven tumor microenvironment remodeling [PDF]

Frontiers in Immunology
BackgroundLung adenocarcinoma (LUAD) is a leading cause of cancer-related mortality. Protein succinylation, a key post-translational modification, is implicated in tumor progression.
Jichang Liu, Xuehan Zhu, Chenlong Zha, Jiaqi Ding, Chuanpeng Zhang, Yizhe Wang, Tao Yan, Hui Kong, Yong Liu, Jingyu Chen, Jingyu Chen   +10 more
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The metabolic-epigenetic interface: lysine succinylation orchestrates bidirectional crosstalk in neurodegenerative disorders [PDF]

Frontiers in Neurology
Succinylation, a nexus between metabolism and epigenetic regulation, is a central factor in the onset and progression of neurodegenerative diseases (NDDs).
Fanglei Chai, Chong Liu, Yandong Liu, Wei Zou   +3 more
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Succinylation: A Functional Nexus Between Metabolic Reprogramming and Epigenetic Modifications in Cancer [PDF]

Molecules
Metabolic reprogramming and epigenetic remodeling are critical features of tumorigenesis. The process of metabolic reprogramming causes metabolites like Succinyl-CoA to accumulate.
Dan Liu, Runtian Li, Mingzhu Li, Fang Xu, Ying Liang, Yang Sun   +5 more
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Biochemical Analysis of Histone Succinylation [PDF]

Biochemistry Research International, 2017
Posttranslational modification (PTM) of proteins is used to regulate protein activity and stability. Histone PTMs are regarded as some of the most important, as they can directly regulate gene expression through chromatin reorganization.
Atsushi Yokoyama, Shogo Katsura, Akira Sugawara   +2 more
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Succinylation: novel molecular mechanisms and prospects for targeted therapy in liver diseases [PDF]

Frontiers in Molecular Biosciences
Succinylation is a novel post-translational modification involving the attachment of a negatively charged succinyl group to lysine residues, which fundamentally alters the structure and function of substrate proteins.
Jie Zhou, Xiaoling Tian, Yifang Zhou, Nianhua Tan, Bin Chen   +4 more
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Succinylation proteomic analysis identified differentially expressed succinylation sites affecting porcine muscle fiber type function

Food Chemistry: X, 2023
Muscle fiber type is a major factor in pork meat quality, however, the role of post-translational protein modifications, especially succinylation, in the regulation of muscle fiber type is not fully understood.
Xiaofan Tan, Kaiqing Liu, Yu He, Zhiwei Yan, Jing Chen, Ruixue Zhao, Xin Sui, Junpeng Zhang, David M. Irwin, Shuyi Zhang, Bojiang Li   +10 more
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Histone acetyltransferase 1 promotes postinfarction inflammatory response by regulation of monocyte histone succinylation [PDF]

Nature Communications
Early activation and phenotypic transformation of monocytes and macrophages are essential for inflammatory activities and tissue repair following myocardial infarction (MI).
Yutong Guo, Jie Xiong, Zhaoyue Li, Liyan Bai, Bo Wang, Bingchen Guo, Hao Tang, Guanghui Li, Yi Qiu, Lin Lv, Zengxiang Dong, Yingfeng Tu   +11 more
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KAT2A-driven succinylation of SRSF11 enforces spliceosome-mediated RAD52 splicing to promote homologous recombination and radioresistance in hepatocellular carcinoma [PDF]

Signal Transduction and Targeted Therapy
Posttranslational modification succinylation plays a pivotal role in tumorigenesis across malignancies, yet its mechanistic contributions to hepatocellular carcinoma (HCC) pathogenesis and therapeutic resistance remain poorly characterized. In this study,
Jun Wu, Jingsheng Yuan, Zijian Liu, Yongjie Zhou, Bo Zhang, Yahong Xu, Qiwen Zeng, Zhenru Wu, Lingxiang Kong, Jiaguo Wang, Bohan Zhang, Jian Yang, Tao Lv, Yujun Shi, Jiayin Yang   +14 more
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Lysine succinylation precisely controls normal erythropoiesis

Haematologica
Lysine succinylation (Ksu) has recently emerged as a protein modification that regulates diverse functions in various biological processes. However, the systemically and precise role of lysine succinylation in erythropoiesis remains to be fully ...
Bin Hu, Han Gong, Ling Nie, Ji Zhang, Yanan Li, Dandan Liu, Huifang Zhang, Haihang Zhang, Lu Han, Chaoying Yang, Maohua Li, Wenwen Xu, Yukio Nakamura, Lihong Shi, Mao Ye, Christopher D. Hillyer, Narla Mohandas, Long Liang, Yue Sheng, Jing Liu   +19 more
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Protein succinylation: regulating metabolism and beyond

Frontiers in Nutrition
Modifications of protein post-translation are critical modulatory processes, which alters target protein biological activity，function and/or location, even involved in pathogenesis of some diseases. So far, there are at least 16 types of post-translation
Xiaoli Hou, Yiqiu Chen, Xiao Li, Xianliang Gu, Weixia Dong, Jie Shi, Shaoping Ji, Shaoping Ji   +7 more
doaj   +3 more sources