Journal of Advanced Research, 2021 Introduction: Major depressive disorder is caused by gene–environment interactions, and the host microbiome has been recognized as an important environmental factor.
Lanxiang Liu +14 more
doaj +3 more sources
Succinylation modification provides new insights for the treatment of immunocompromised individuals with drug-resistant Aspergillus fumigatus infection. [PDF]
Front Immunol, 2023 Invasive Aspergillus fumigatus infection poses a serious threat to global human health, especially to immunocompromised individuals. Currently, triazole drugs are the most commonly used antifungals for aspergillosis.
Chen X +7 more
europepmc +3 more sources
Dynamic lysine acetylation and succinylation of platelet proteins regulates platelet storage lesion: mechanistic insights from multi-omics [PDF]
Annals of MedicineObjectives Platelet storage lesion (PSL) severely impairs platelet function during storage, presenting a major hurdle in transfusion medicine; however, the dynamic interplay between global proteomic changes and post-translational modifications (PTMs ...
Xin Liao +8 more
doaj +2 more sources
LDHA Desuccinylase Sirtuin 5 as A Novel Cancer Metastatic Stimulator in Aggressive Prostate Cancer [PDF]
Genomics, Proteomics & Bioinformatics, 2023 Prostate cancer (PCa) is the most commonly diagnosed genital cancer in men worldwide. Around 80% of the patients who developed advanced PCa suffered from bone metastasis, with a sharp drop in the survival rate.
Oh Kwang Kwon +14 more
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Adipose tissue protein profiling: modulation by vitamin D receptor [PDF]
Frontiers in NutritionBackgroundLittle is known regarding the expression patterns of adipose tissue proteins in the context of vitamin D deficiency and whether these expression patterns have adverse effects on fat-related diseases.MethodsThis study compares vitamin D receptor-
Ding Ding +7 more
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The first succinylome profile of Trichophyton rubrum reveals lysine succinylation on proteins involved in various key cellular processes [PDF]
BMC Genomics, 2017 Background Dermatophytes, the most common cause of fungal infections, affect millions of individuals worldwide. They pose a major threat to public health because of the severity and longevity of infections caused by dermatophytes and their refractivity ...
Xingye Xu +7 more
doaj +3 more sources
Sirtuin 5-mediated desuccinylation of Slc25a4 inhibits osteoporosis by enhancing mitochondrial respiration [PDF]
Bone ResearchOsteoporosis is a prevalent metabolic bone disorder that develops when osteoclast-mediated bone resorption chronically exceeds osteoblast-driven bone formation.
Jun Chen, Xinquan Jiang
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Sirt5-mediated desuccinylation of OPTN protects retinal ganglion cells from autophagic flux blockade in diabetic retinopathy [PDF]
Cell Death Discovery, 2022 Retinal neurodegeneration develops early in the course of diabetic retinopathy (DR), and our previous research showed that succinate accumulation results in retinal ganglion cells (RGCs) dysfunction in the retinas of rats with DR.
Ye Zhang +6 more
doaj +2 more sources
The crotonylated and succinylated proteins of jujube involved in phytoplasma-stress responses [PDF]
BMC BiologyBackground Protein posttranslational modifications (PTMs) are fast and early responses to environmental changes, including pathogen infection. Jujube witches’ broom (JWB) is a phytoplasma disease causing great economic loss in jujube production.
Liman Zhang +8 more
doaj +2 more sources
DLST mutations in pheochromocytoma and paraganglioma cause proteome hyposuccinylation and metabolic remodeling. [PDF]
Cancer Commun (Lond), 2023 Cancer Communications, Volume 43, Issue 7, Page 838-843, July 2023.
Mellid S +28 more
europepmc +2 more sources