Fucans, but Not Fucomannoglucuronans, Determine the Biological Activities of Sulfated Polysaccharides From Laminaria saccharina Brown Seaweed [PDF]
PLoS ONE, 2011 Sulfated polysaccharides from Laminaria saccharina (new name: Saccharina latissima) brown seaweed show promising activity for the treatment of inflammation, thrombosis, and cancer; yet the molecular mechanisms underlying these properties remain poorly ...
Nicola Tinari +2 more
exaly +11 more sources
Effects of Sulfated Fucans from Laminaria hyperborea Regarding VEGF Secretion, Cell Viability, and Oxidative Stress and Correlation with Molecular Weight [PDF]
Marine Drugs, 2019 Background: Sulfated fucans show interesting effects in the treatment of ocular diseases (e.g., age-related macular degeneration), depending on their chemical structure.
Philipp Dörschmann +3 more
doaj +4 more sources
Marine Non-Glycosaminoglycan Sulfated Glycans as Potential Pharmaceuticals
Pharmaceuticals, 2015 Sulfated fucans (SFs) and sulfated galactans (SGs) are currently the marine non-glycosaminoglycan (GAG) sulfated glycans most studied in glycomics.
Vitor H Pomin
exaly +4 more sources
Sulfated Glycans Inhibit the Interaction of MERS-CoV Receptor Binding Domain with Heparin [PDF]
VirusesMiddle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus with high contagion and mortality rates. Heparan sulfate proteoglycans (HSPGs) are ubiquitously expressed on the surface of mammalian cells.
Jiyuan Yang +12 more
doaj +3 more sources
Phlorotannins and Fucans from Phaeophyceae as Phaeophyceae Agrochemical Leads: Structural Diversity, Molecular Mechanisms, and Delivery Systems [PDF]
Marine DrugsThe increasing demand for sustainable agricultural practices has intensified the search for biobased alternatives to synthetic agrochemicals. In this context, marine macroalgae, particularly brown algae (Phaeophyceae), represent a largely underexplored ...
Isabelle Soares +4 more
doaj +2 more sources
Binding properties of marine sulfated glycans to coagulation (co)-factors using surface plasmon resonance spectroscopy [PDF]
Scientific ReportsMarine sulfated glycans (MSGs) are a rich source of novel structures with unique biological activities, particularly in anticoagulation and antithrombosis.
Hoda Al. Ahmed, Vitor H. Pomin
doaj +2 more sources
Selective 2-Desulfation of Tetrasaccharide-Repeating Sulfated Fucans During Oligosaccharide Production by Mild Acid Hydrolysis [PDF]
Carbohydrate Polymers, 2023 Seon Beom Kim +2 more
exaly +2 more sources
Direct Antitumoral Effects of Sulfated Fucans Isolated From Echinoderms: A Possible Role of Neuropilin-1/β1 Integrin Endocytosis and Focal Adhesion Kinase Degradation. [PDF]
Glycobiology, 2023 Paulo A.S. Mourão +2 more
exaly +2 more sources
Frontiers in Microbiology, 2020 Sulfated fucans are important marine polysaccharides widely distributed in brown algae and echinoderms, which gained increasing research interest for their various biological and biomedical activities.
Jingjing Shen +6 more
doaj +1 more source
Antiviral activity of marine sulfated glycans against pathogenic human coronaviruses
Scientific Reports, 2023 Great interest exists towards the discovery and development of broad-spectrum antivirals. This occurs due to the frequent emergence of new viruses which can also eventually lead to pandemics.
Mary Zoepfl +4 more
doaj +1 more source