Fucans, but Not Fucomannoglucuronans, Determine the Biological Activities of Sulfated Polysaccharides from Laminaria saccharina Brown Seaweed [PDF]
PLoS ONE, 2011 Sulfated polysaccharides from Laminaria saccharina (new name: Saccharina latissima) brown seaweed show promising activity for the treatment of inflammation, thrombosis, and cancer; yet the molecular mechanisms underlying these properties remain poorly ...
Diego O Croci +2 more
exaly +8 more sources
Selective 2-desulfation of tetrasaccharide-repeating sulfated fucans during oligosaccharide production by mild acid hydrolysis [PDF]
Carbohydrate Polymers, 2023 Sulfated fucans (SFs) from echinoderms, such as sea cucumbers and sea urchins, present linear and regular sulfation patterns within defined oligosaccharide building blocks. The high molecular weights of these polymers pose a problem in advanced structure-activity relationship studies for which derived oligosaccharides are more appropriate tools for ...
Seon Beom Kim +2 more
exaly +4 more sources
Effects of Sulfated Fucans from Laminaria hyperborea Regarding VEGF Secretion, Cell Viability, and Oxidative Stress and Correlation with Molecular Weight [PDF]
Marine Drugs, 2019 Background: Sulfated fucans show interesting effects in the treatment of ocular diseases (e.g., age-related macular degeneration), depending on their chemical structure.
Philipp Dörschmann +3 more
doaj +2 more sources
Fucose-Containing Sulfated Polysaccharides from Brown Seaweeds Inhibit Proliferation of Melanoma Cells and Induce Apoptosis by Activation of Caspase-3 in Vitro [PDF]
Marine Drugs, 2011 Fucose-containing sulfated polysaccharides (FCSPs) extracted from seaweeds, especially brown macro-algae, are known to possess essential bioactive properties, notably growth inhibitory effects on tumor cells.
Anne S. Meyer +4 more
doaj +3 more sources
Antiproliferative Activity of Fucan Nanogel [PDF]
Marine Drugs, 2012 Sulfated fucans comprise families of polydisperse natural polysaccharides based on sulfated l-fucose. Our aim was to investigate whether fucan nanogel induces cell-specific responses.
Francisco Miguel Gama +8 more
doaj +4 more sources
A fucan from the brown seaweed Spatoglossum schröederi inhibits Chinese hamster ovary cell adhesion to several extracellular matrix proteins [PDF]
Brazilian Journal of Medical and Biological Research, 2001 Fucans, a family of sulfated polysaccharides present in brown seaweed, have several biological activities. Their use as drugs would offer the advantage of no potential risk of contamination with viruses or particles such as prions.
H.A.O. Rocha +7 more
doaj +3 more sources
Binding properties of marine sulfated glycans to coagulation (co)-factors using surface plasmon resonance spectroscopy [PDF]
Scientific ReportsMarine sulfated glycans (MSGs) are a rich source of novel structures with unique biological activities, particularly in anticoagulation and antithrombosis.
Hoda Al. Ahmed, Vitor H. Pomin
doaj +2 more sources
Sulfated Glycans Inhibit the Interaction of MERS-CoV Receptor Binding Domain with Heparin [PDF]
VirusesMiddle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus with high contagion and mortality rates. Heparan sulfate proteoglycans (HSPGs) are ubiquitously expressed on the surface of mammalian cells.
Jiyuan Yang +12 more
doaj +2 more sources
Marine Non-Glycosaminoglycan Sulfated Glycans as Potential Pharmaceuticals
Pharmaceuticals, 2015 Sulfated fucans (SFs) and sulfated galactans (SGs) are currently the marine non-glycosaminoglycan (GAG) sulfated glycans most studied in glycomics.
Vitor H Pomin
exaly +3 more sources
Frontiers in Microbiology, 2020 Sulfated fucans are important marine polysaccharides widely distributed in brown algae and echinoderms, which gained increasing research interest for their various biological and biomedical activities.
Jingjing Shen +6 more
doaj +1 more source