Results 51 to 60 of about 17,770 (172)

Research Review on Inhibitors of Lumpy Skin Disease Virus: From Biological Characteristics, Drug Repurposing, to Computer‐Aided Drug Design

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
This review summarizes the research progress on inhibitors of lumpy skin disease virus (LSDV), focusing on its biological characteristics and key proteins involved in the viral replication cycle. It compiles various inhibitors (direct‐acting poxvirus inhibitors and host‐directed poxvirus inhibitors) against poxviruses, their mechanisms of action, and ...
Leilei ZHAO, Jing QU, Miao AN, Yang LIU, Xiubo LI, Yiming LIU, Chen PENG, Todd R. Callaway   +7 more
wiley   +1 more source

A fucan from the brown seaweed Spatoglossum schröederi inhibits Chinese hamster ovary cell adhesion to several extracellular matrix proteins

Brazilian Journal of Medical and Biological Research, 2001
Fucans, a family of sulfated polysaccharides present in brown seaweed, have several biological activities. Their use as drugs would offer the advantage of no potential risk of contamination with viruses or particles such as prions.
H.A.O. Rocha, C.R.C. Franco, E.S. Trindade, L.C.M. Carvalho, S.S. Veiga, E.L. Leite, C.P. Dietrich, H.B. Nader   +7 more
doaj   +1 more source

The cell wall polysaccharide metabolism of the brown alga Ectocarpus siliculosus. Insights into the evolution of extracellular matrix polysaccharides in Eukaryotes

, 2010
International audienceBrown algal cell walls share some components with plants (cellulose) and animals (sulfated fucans), but they also contain some unique polysaccharides (alginates).
Bernard Kloareg, Delphine Scornet, Cock, J. Mark, Gurvan Michel, Scornet, Delphine, Tonon, Thierry, Kloareg, Bernard, Thierry Tonon, Michel, Gurvan, J. Mark Cock   +9 more
core   +1 more source

Sulfatases: Catalytic Mechanism, Substrate Preferences, and Carbohydrate‐Based Inhibitor Design

Israel Journal of Chemistry, Volume 65, Issue 12, December 2025.
Sulfatases are a class of enzymes that can cleave sulfates from heparan sulfate and modulate many of their biological activities. In this review, following a general introduction on sulfatase, their enzymatic mechanism and substrate scope are discussed.
Morgan Mayieka, Julius Benicky, Radoslav Goldman, Xuefei Huang   +3 more
wiley   +1 more source

Antioxidant Fucoidans Obtained from Tropical Seaweed Protect Pre-Osteoblastic Cells from Hydrogen Peroxide-Induced Damage

Marine Drugs, 2019
Some antioxidant compounds decrease the amount of intracellular reactive oxygen species (ROS) and consequently reduce the deleterious effects of ROS in osteoblasts. Thus, these compounds fight against osteoporosis.
Gabriel Pereira Fidelis, Cynthia Haynara Ferreira Silva, Leonardo Thiago Duarte Barreto Nobre, Valquíria Pereira Medeiros, Hugo Alexandre Oliveira Rocha, Leandro Silva Costa   +5 more
doaj   +1 more source

Structural Characterization and Physicochemical Property of a Purified Fucosylated Glycosaminoglycan Sulfate From Holothuria leucospilota

eFood, Volume 6, Issue 4, August 2025.
(1) The main chain structure of Holothuria leucospilota polysaccharides (HLP‐Ⅰ) was presumed to be roughly as →3)‐β‐d‐GalpNAc‐(1→4)‐β‐d‐GlcpA‐(1→. (2) with T‐Fucp on the branched chain or a rockulose chain consisting of →3,4)‐α‐l‐Fucp‐(1→. (3) HLP‐Ⅰ showed high amorphous platelet content and disordered arrangement, while the molecule adapted a sphere ...
Wanting Wang, Kexue Zhu, Jun Cao, Shunjiang Zeng, Lijun You, Chao Zhao, Yuanping Zheng, Chuan Li   +7 more
wiley   +1 more source

Fucoidan From Brown Algae as a Functional Food Ingredient: A Promising Anticancer Agent

eFood, Volume 6, Issue 4, August 2025.
Fucoidan, a bioactive polysaccharide from brown algae, inhibits receptor tyrosine kinase (RTK) activation and vascular endothelial growth factor (VEGF) signaling, suppressing the phosphoinositide 3‐kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) and RAS/RAF/mitogen‐activated protein kinase/extracellular signal‐regulated kinase ...
Muhammad Umer Khan, Iqra Khurram, Maha Munir, Muhammad Ikram Ullah, Heba Bassiony Ghanem, Javad Sharifi‐Rad, William N. Setzer, Daniela Calina   +7 more
wiley   +1 more source

The specificity of interactions between proteins and sulfated polysaccharides

Anais da Academia Brasileira de Ciências, 2005
Sulfated polysaccharides are capable of binding with proteins at several levels of specificity. As highly acidic macromolecules, they can bind non-specifically to any basic patch on a protein surface at low ionic strength, and such interactions are not ...
Barbara Mulloy
doaj   +1 more source

The structure of a family 168 glycoside hydrolase from the marine bacterium Muricauda eckloniae

Acta Crystallographica Section F, Volume 81, Issue 7, Page 281-286, July 2025.
The structure of a putative fucoidan‐degrading glycoside hydrolase assigned to glycoside hydrolase family 168 reveals a (β/α)8 fold. The catalytic machinery and potential substrate specificity were investigated through a structural comparison with a Fun168A oligosaccharide complex.The genome of the marine bacterium Muricauda eckloniae sp.
Emily Knudson-Goerner, Alisdair B. Boraston   +1 more
wiley   +1 more source

Bioactive Compounds in Seafood: Implications for Health and Nutrition

Food Science &Nutrition, Volume 13, Issue 4, April 2025.
Seafood is vital in promoting cardiovascular health, regulating blood sugar levels, reducing the risk of specific cancers, combating obesity, enhancing brain health, and supporting maternal care during pregnancy and lactation. Given the rising interest in functional foods and nutraceuticals, I believe this review will be particularly interesting to ...
Tabussam Tufail, Huma Bader Ul Ain, Jawad Ashraf, Sammina Mahmood, Sana Noreen, Aiman Ijaz, Ali ikram, Muhammad Tayyab Arshad, Muhammed Adem Abdullahi   +8 more
wiley   +1 more source