Transfer of electrophilic NH using convenient sources of ammonia: direct synthesis of N–H sulfoximines from sulfoxides [PDF]
Angewandte Chemie, 2016 The transfer of nitrogen atoms is extremely valuable in the preparation of medicinal compounds. Here, a new system for NH transfer is developed to prepare sulfoximines, which are emerging as valuable motifs for drug discovery.
Bentley +43 more
core +2 more sources
Angewandte Chemie, 2022 The intermediate oxidation state of sulfoxides is central to the plethora of their applications in chemistry and medicine, yet it presents challenges for an efficient synthetic access, limiting the structural diversity of currently available sulfoxides ...
Viet D Nguyen +6 more
semanticscholar +1 more source
Frontiers in Chemistry, 2021 Chiral sulfoxides are valuable organosulfur compounds that have been widely used in medicinal and organic synthesis. Biocatalytic approaches for preparing chiral sulfoxides were developed in the past few years, mainly through asymmetric oxidation of ...
Tao Peng +4 more
doaj +1 more source
A Sulfoxide Reagent for One‐Pot, Three‐Component Syntheses of Sulfoxides and Sulfinamides
Angewandte Chemie, 2022 Sulfoxides and sulfinamides represent versatile sulfur functional groups found in ligands, chiral auxiliaries, and bioactive molecules. Canonical two‐component syntheses, however, rely on substrates with a preinstalled C−S bond and impede efficient and ...
Fumito Saito
semanticscholar +1 more source
Research progress on metabolic pathway of S-alk(en)ylcysteine sulfoxides in Allium
Guangxi Zhiwu, 2023 Allium L. is one of the largest genera of angiosperms, including garlic, onion, green Chinese onion, Chinese chive and other important vegetable crops with unique spicy flavor.
Huamin ZHANG +4 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2021 A series of 1-heteroatom-substituted vinyl p-tolyl sulfoxides were prepared and treated with organometallic reagents to evaluate which combination of sulfoxides and organometallic reagents yielded alkynes the most efficiently.
Tsutomu Kimura +3 more
doaj +1 more source
Advance in the Synthesis of Sulfoxides and Sulfinamides from β-Sulfinyl Esters
Organics, 2023 Sulfoxides and sulfinamides play important roles in the pharmaceutical industry, organic synthesis and fine chemicals. This review will demonstrate that, under catalysis by transition metals, β-sulfinyl esters, as nucleophilic reagents, react with a ...
Xianjie Yin, Qiaoling Zhang, Qingle Zeng
doaj +1 more source
Flow Electrosynthesis of Sulfoxides, Sulfones, and Sulfoximines without Supporting Electrolytes.
Journal of Organic Chemistry, 2021 An efficient electrochemical flow process for the selective oxidation of sulfides to sulfoxides and sulfones and of sulfoxides to N-cyanosulfoximines has been developed.
Nasser Amri, T. Wirth
semanticscholar +1 more source
Synthesis and Preliminary Screening of the Biological Activity of Sulindac Sulfoximine Derivatives
Applied Sciences, 2023 Sulindac is a well-known anti-inflammatory agent, sometimes employed as an adjuvant in antitumor therapy. Due to the recent interest in sulfoximine for its potential chemotherapeutics, we decided to transform sulindac and its methyl ester into the ...
Cosimo Cardellicchio +6 more
doaj +1 more source
Stereoselective Synthesis of Chiral C2-Symmetric 1,3- and 1,5-Bis-Sulfoxides Guided by the Horeau Principle: Understanding the Influence of the Carbon Chain Nature in Its Ability for Metal Coordination. [PDF]
J Org ChemMoreno-Rodríguez N +4 more
europepmc +2 more sources