Results 11 to 20 of about 333,029 (290)
cAMP-Inhibits Cytoplasmic Phospholipase A2 and Protects Neurons against Amyloid-β-Induced Synapse Damage [PDF]
Biology, 2015 A key event in Alzheimer’s disease (AD) is the production of amyloid-β (Aβ) peptides and the loss of synapses. In cultured neurons Aβ triggered synapse damage as measured by the loss of synaptic proteins. α-synuclein (αSN), aggregates of which accumulate
Clive Bate, Alun Williams
doaj +4 more sources
Modeling Maintenance of Long-Term Potentiation in Clustered Synapses, Long-Term Memory Without Bistability [PDF]
, 2015 Memories are stored, at least partly, as patterns of strong synapses. Given molecular turnover, how can synapses maintain strong for the years that memories can persist?
Smolen, Paul
core +4 more sources
Frontiers in Neuroscience, 2022 Bacterial infections are a common cause of morbidity and mortality in the elderly, and particularly in individuals with a neurodegenerative disease. Experimental models of neurodegeneration have shown that LPS-induced systemic inflammation increases ...
Joe K. Chouhan +3 more
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Neuron, 2013 The constant dynamic movement of synapses and their components has emerged in the last decades as a key feature of synaptic transmission and its plasticity. Intramolecular protein movements drive conformation changes important to transduce transmitter binding into signaling. Constant cytoskeletal rearrangements power synapse shape movements.
Daniel Choquet, Antoine Triller
openaire +2 more sources
Rapid, learning-induced inhibitory synaptogenesis in murine barrel field [PDF]
, 2010 The structure of neurons changes during development and in response to injury or alteration in sensory experience. Changes occur in the number, shape, and dimensions of dendritic spines together with their synapses. However, precise data on these changes
Cybulska-Klosowicz, A +6 more
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Interaction and Subcellular Association of PRRT1/SynDIG4 With AMPA Receptors
Frontiers in Synaptic Neuroscience, 2021 AMPA receptors (AMPAR) are organized into supramolecular complexes in association with other membrane proteins that provide exquisite regulation of their biophysical properties and subcellular trafficking.
Emily Eischen Martin +3 more
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Adenosine A1 receptor activation mediates the developmental shift at layer 5 pyramidal cell synapses and is a determinant of mature synaptic strength [PDF]
, 2013 During the first postnatal month glutamatergic synapses between layer 5 pyramidal cells in the rodent neocortex switch from an immature state exhibiting high probability of neurotransmitter release, large unitary amplitude and synaptic depression to a ...
Dunwiddie TV +3 more
core +1 more source
A CMOS Spiking Neuron for Brain-Inspired Neural Networks with Resistive Synapses and In-Situ Learning [PDF]
, 2015 Nanoscale resistive memories are expected to fuel dense integration of electronic synapses for large-scale neuromorphic system. To realize such a brain-inspired computing chip, a compact CMOS spiking neuron that performs in-situ learning and computing ...
Balagopal, Sakkarapani +3 more
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Synapses immunologiques et synapses neuronales [PDF]
médecine/sciences, 2003 Les systemes nerveux et immunitaire ont en commun de constituer dans l’organisme des reseaux complexes de cellules en interaction. Dans ces reseaux transitent en permanence d’enormes quantites d’informations, codees de facon tres differente dans les deux cas. Ces informations doivent en particulier circuler de cellule en cellule.
Trautmann, Alain +3 more
openaire +2 more sources
Connexin36 Expression in the Mammalian Retina: A Multiple-Species Comparison
Frontiers in Cellular Neuroscience, 2017 Much knowledge about interconnection of human retinal neurons is inferred from results on animal models. Likewise, there is a lack of information on human retinal electrical synapses/gap junctions (GJ).
Tamás Kovács-Öller +25 more
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