Results 21 to 30 of about 187,009 (324)
Frontiers in Neuroscience, 2022 Bacterial infections are a common cause of morbidity and mortality in the elderly, and particularly in individuals with a neurodegenerative disease. Experimental models of neurodegeneration have shown that LPS-induced systemic inflammation increases ...
Joe K. Chouhan +3 more
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Interaction and Subcellular Association of PRRT1/SynDIG4 With AMPA Receptors
Frontiers in Synaptic Neuroscience, 2021 AMPA receptors (AMPAR) are organized into supramolecular complexes in association with other membrane proteins that provide exquisite regulation of their biophysical properties and subcellular trafficking.
Emily Eischen Martin +3 more
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Electrochemistry at the Synapse [PDF]
Annual Review of Analytical Chemistry, 2019 Electrochemical measurements of neurotransmitters provide insight into the dynamics of neurotransmission. In this review, we describe the development of electrochemical measurements of neurotransmitters and how they started with extrasynaptic measurements but now are pushing toward synaptic measurements.
Jason R. Borgus +3 more
openaire +3 more sources
Autophagy at the synapse [PDF]
Neuroscience Letters, 2019 As the sites of communication between neurons, synapses depend upon precisely regulated protein-protein interactions to support neurotransmitter release and reception. Moreover, neuronal synapses typically exist great distances (i.e. up to meters) away from cell bodies, which are the sources of new proteins and the major sites of protein degradation ...
Clarissa L. Waites +2 more
openaire +3 more sources
Connexin36 Expression in the Mammalian Retina: A Multiple-Species Comparison
Frontiers in Cellular Neuroscience, 2017 Much knowledge about interconnection of human retinal neurons is inferred from results on animal models. Likewise, there is a lack of information on human retinal electrical synapses/gap junctions (GJ).
Tamás Kovács-Öller +25 more
doaj +1 more source
eLife, 2023 The joint storage and reciprocal retrieval of learnt associated signals are presumably encoded by associative memory cells. In the accumulation and enrichment of memory contents in lifespan, a signal often becomes a core signal associatively shared for ...
Yang Xu +4 more
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The combined effect of chemical and electrical synapses in small Hindmarsch-Rose neural networks on synchronisation and on the rate of information [PDF]
Phys. Rev. E, vol. 82, 036203 (2010), 2009 In this work we studied the combined action of chemical and electrical synapses in small networks of Hindmarsh-Rose (HR) neurons on the synchronous behaviour and on the rate of information produced (per time unit) by the networks. We show that if the chemical synapse is excitatory, the larger the chemical synapse strength used the smaller the ...
arxiv +1 more source
SynEM, automated synapse detection for connectomics
eLife, 2017 Nerve tissue contains a high density of chemical synapses, about 1 per µm3 in the mammalian cerebral cortex. Thus, even for small blocks of nerve tissue, dense connectomic mapping requires the identification of millions to billions of synapses. While the
Benedikt Staffler +5 more
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Intracellular Trafficking Mechanisms of Synaptic Dysfunction in Alzheimer’s Disease
Frontiers in Cellular Neuroscience, 2020 Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by progressive memory loss. Although AD neuropathological hallmarks are extracellular amyloid plaques and intracellular tau tangles, the best correlate of disease ...
Catarina Perdigão +5 more
doaj +1 more source
Cells, 2021 The extracellular matrix (ECM) plays a key role in synaptogenesis and the regulation of synaptic functions in the central nervous system. Recent studies revealed that in addition to dopaminergic and serotoninergic neuromodulatory systems, microglia also ...
Luisa Strackeljan +6 more
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