Results 21 to 30 of about 326,223 (328)

LRP4 is required for the olfactory association task in the piriform cortex

Cell & Bioscience, 2022
Background Low-density lipoprotein receptor-related protein 4 (LRP4) plays a critical role in the central nervous system (CNS), including hippocampal synaptic plasticity, maintenance of excitatory synaptic transmission, fear regulation, as well as long ...
Min Yan, Mingtao Xiong, Yongqiang Wu, Dong Lin, Peng Chen, Jiang Chen, Ziyang Liu, Hang Zhang, Dongyan Ren, Erkang Fei, Xinsheng Lai, Suqi Zou, Shunqi Wang   +12 more
doaj   +1 more source

Impaired synaptic incorporation of AMPA receptors in a mouse model of fragile X syndrome

Frontiers in Molecular Neuroscience, 2023
Fragile X syndrome (FXS) is the most common monogenetic cause of inherited intellectual disability and autism in humans. One of the well-characterized molecular phenotypes of Fmr1 KO mice, a model of FXS, is increased translation of synaptic proteins ...
Magdalena Chojnacka, Anna Beroun, Marta Magnowska, Aleksandra Stawikowska, Dominik Cysewski, Jacek Milek, Magdalena Dziembowska, Bozena Kuzniewska   +7 more
doaj   +1 more source

Subcellular RNA-seq for the Analysis of the Dendritic and Somatic Transcriptomes of Single Neurons

Bio-Protocol, 2022
In neurons, local translation in dendritic and axonal compartments allows for the fast and on-demand modification of the local proteome. As the last few years have witnessed dramatic advancements in our appreciation of the brain’s neuronal diversity, it ...
Julio Perez, Erin Schuman
doaj   +1 more source

Metformin Ameliorates Lipopolysaccharide-Induced Depressive-Like Behaviors and Abnormal Glutamatergic Transmission

Biology, 2020
Metformin, a first-line drug for type 2 diabetes mellitus (T2DM), has been found to reduce depressive symptoms in patients with comorbid depression and other diseases.
Jiang Chen, Tian Zhou, A-Min Guo, Wen-Bing Chen, Dong Lin, Zi-Yang Liu, Er-Kang Fei   +6 more
doaj   +1 more source

Neuromodulation of the feedforward dentate gyrus-CA3 microcircuit

Frontiers in Synaptic Neuroscience, 2016
The feedforward dentate gyrus-CA3 microcircuit in the hippocampus is thought to activate ensembles of CA3 pyramidal cells and interneurons to encode and retrieve episodic memories.
Luke Yuri Prince, Travis J Bacon, Cezar M. Tigaret, Jack R Mellor   +3 more
doaj   +1 more source

Metformin Increases Sarcolemma Integrity and Ameliorates Neuromuscular Deficits in a Murine Model of Duchenne Muscular Dystrophy

Frontiers in Physiology, 2021
Duchenne muscular dystrophy (DMD) is a genetic neuromuscular disease characterized by progressive muscle weakness and wasting. Stimulation of AMP-activated protein kinase (AMPK) has been demonstrated to increase muscle function and protect muscle against
Xia Dong, Xia Dong, Tiankun Hui, Tiankun Hui, Jie Chen, Jie Chen, Zheng Yu, Dongyan Ren, Dongyan Ren, Suqi Zou, Suqi Zou, Shunqi Wang, Shunqi Wang, Erkang Fei, Erkang Fei, Huifeng Jiao, Xinsheng Lai, Xinsheng Lai   +17 more
doaj   +1 more source

Effects of Synaptic and Myelin Plasticity on Learning in a Network of Kuramoto Phase Oscillators [PDF]

, 2019
Models of learning typically focus on synaptic plasticity. However, learning is the result of both synaptic and myelin plasticity. Specifically, synaptic changes often co-occur and interact with myelin changes, leading to complex dynamic interactions ...
D. Dibenedetto, Haken H., Hebb D. O., Kuramoto Y., M. Karimian, M. Moerel, M. Senden, P. De Weerd, Pikovsky A., R. L. Westra, T. Burwick   +10 more
core   +2 more sources

The C-terminal helix 9 motif in rat cannabinoid receptor type 1 regulates axonal trafficking and surface expression

eLife, 2019
Cannabinoid type one receptor (CB1R) is only stably surface expressed in axons, where it downregulates neurotransmitter release. How this tightly regulated axonal surface polarity is established and maintained is unclear.
Alexandra Fletcher-Jones, Keri L Hildick, Ashley J Evans, Yasuko Nakamura, Kevin A Wilkinson, Jeremy M Henley   +5 more
doaj   +1 more source

AMPA Receptor Phosphorylation and Synaptic Colocalization on Motor Neurons Drive Maladaptive Plasticity below Complete Spinal Cord Injury. [PDF]

, 2015
Clinical spinal cord injury (SCI) is accompanied by comorbid peripheral injury in 47% of patients. Human and animal modeling data have shown that painful peripheral injuries undermine long-term recovery of locomotion through unknown mechanisms ...
Beattie, Michael S, Bresnahan, Jacqueline C, Ferguson, Adam R, Grau, James W, Huie, J Russell, Irvine, Karen-Amanda, Lee, Kuan H, Stuck, Ellen D   +7 more
core   +1 more source

Surface biotinylation of primary neurons to monitor changes in AMPA receptor surface expression in response to kainate receptor stimulation

STAR Protocols, 2021
Summary: Here, we detail a surface biotinylation technique used to label surface-expressed proteins in primary neuronal cultures. Surface proteins are labeled with membrane-impermeant Sulfo-NHS-SS-biotin, and isolated by pull-down with streptavidin beads
Jithin D. Nair, Jeremy M. Henley, Kevin A. Wilkinson   +2 more
doaj   +1 more source