Results 21 to 30 of about 724,295 (381)

Neuromodulation of the feedforward dentate gyrus-CA3 microcircuit

Frontiers in Synaptic Neuroscience, 2016
The feedforward dentate gyrus-CA3 microcircuit in the hippocampus is thought to activate ensembles of CA3 pyramidal cells and interneurons to encode and retrieve episodic memories.
Luke Yuri Prince, Travis J Bacon, Cezar M. Tigaret, Jack R Mellor   +3 more
doaj   +1 more source

Metformin Increases Sarcolemma Integrity and Ameliorates Neuromuscular Deficits in a Murine Model of Duchenne Muscular Dystrophy

Frontiers in Physiology, 2021
Duchenne muscular dystrophy (DMD) is a genetic neuromuscular disease characterized by progressive muscle weakness and wasting. Stimulation of AMP-activated protein kinase (AMPK) has been demonstrated to increase muscle function and protect muscle against
Xia Dong, Xia Dong, Tiankun Hui, Tiankun Hui, Jie Chen, Jie Chen, Zheng Yu, Dongyan Ren, Dongyan Ren, Suqi Zou, Suqi Zou, Shunqi Wang, Shunqi Wang, Erkang Fei, Erkang Fei, Huifeng Jiao, Xinsheng Lai, Xinsheng Lai   +17 more
doaj   +1 more source

Effects of Synaptic and Myelin Plasticity on Learning in a Network of Kuramoto Phase Oscillators [PDF]

, 2019
Models of learning typically focus on synaptic plasticity. However, learning is the result of both synaptic and myelin plasticity. Specifically, synaptic changes often co-occur and interact with myelin changes, leading to complex dynamic interactions ...
D. Dibenedetto, Haken H., Hebb D. O., Kuramoto Y., M. Karimian, M. Moerel, M. Senden, P. De Weerd, Pikovsky A., R. L. Westra, T. Burwick   +10 more
core   +2 more sources

A mechanistic hypothesis for the impairment of synaptic plasticity by soluble Aβ oligomers from Alzheimer’s brain

Journal of Neurochemistry, 2020
It is increasingly accepted that early cognitive impairment in Alzheimer's disease results in considerable part from synaptic dysfunction caused by the accumulation of a range of oligomeric assemblies of amyloid β‐protein (Aβ).
Shaomin Li, D. Selkoe
semanticscholar   +1 more source

Optogenetics and synaptic plasticity [PDF]

Acta Pharmacologica Sinica, 2013
The intricate and complex interaction between different populations of neurons in the brain has imposed limits on our ability to gain detailed understanding of synaptic transmission and its integration when employing classical electrophysiological approaches. Indeed, electrical field stimulation delivered via traditional microelectrodes does not permit
John F. MacDonald, Yu-Feng Xie, Michael F. Jackson, Michael F. Jackson   +3 more
openaire   +3 more sources

Bidirectional synaptic plasticity rapidly modifies hippocampal representations

bioRxiv, 2020
Learning requires neural adaptations thought to be mediated by activity-dependent synaptic plasticity. A relatively non-standard form of synaptic plasticity driven by dendritic plateau potentials has been reported to underlie place field formation in ...
Aaron D. Milstein, Yiding Li, Katie C. Bittner, Christine Grienberger, I. Soltesz, J. Magee, S. Romani   +6 more
semanticscholar   +1 more source

Stress gates an astrocytic energy reservoir to impair synaptic plasticity

Nature Communications, 2020
Astrocytes support the energy demands of synaptic transmission and plasticity. Enduring changes in synaptic efficacy are highly sensitive to stress, yet whether changes to astrocyte bioenergetic control of synapses contributes to stress-impaired ...
Ciaran Murphy-Royal, April D. Johnston, A. K. Boyce, Blanca Díaz-Castro, A. Institoris, Govind Peringod, Oliver Zhang, Randy F. Stout, D. Spray, Roger J. Thompson, B. Khakh, J. Bains, G. Gordon   +12 more
semanticscholar   +1 more source

The C-terminal helix 9 motif in rat cannabinoid receptor type 1 regulates axonal trafficking and surface expression

eLife, 2019
Cannabinoid type one receptor (CB1R) is only stably surface expressed in axons, where it downregulates neurotransmitter release. How this tightly regulated axonal surface polarity is established and maintained is unclear.
Alexandra Fletcher-Jones, Keri L Hildick, Ashley J Evans, Yasuko Nakamura, Kevin A Wilkinson, Jeremy M Henley   +5 more
doaj   +1 more source

AMPA Receptor Phosphorylation and Synaptic Colocalization on Motor Neurons Drive Maladaptive Plasticity below Complete Spinal Cord Injury. [PDF]

, 2015
Clinical spinal cord injury (SCI) is accompanied by comorbid peripheral injury in 47% of patients. Human and animal modeling data have shown that painful peripheral injuries undermine long-term recovery of locomotion through unknown mechanisms ...
Beattie, Michael S, Bresnahan, Jacqueline C, Ferguson, Adam R, Grau, James W, Huie, J Russell, Irvine, Karen-Amanda, Lee, Kuan H, Stuck, Ellen D   +7 more
core   +1 more source

Astrocyte-secreted IL-33 mediates homeostatic synaptic plasticity in the adult hippocampus

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Synaptic plasticity in the hippocampus is important for learning and memory formation. In particular, homeostatic synaptic plasticity enables neurons to restore their activity levels in response to chronic neuronal activity changes.
Ye Wang, W. Fu, Kit Cheung, K. Hung, Congping Chen, Hongyan Geng, W. Yung, J. Qu, A. Fu, N. Ip   +9 more
semanticscholar   +1 more source