Results 21 to 30 of about 324,242 (283)

The malleable brain: plasticity of neural circuits and behavior: A review from students to students [PDF]

, 2017
One of the most intriguing features of the brain is its ability to be malleable, allowing it to adapt continually to changes in the environment. Specific neuronal activity patterns drive long-lasting increases or decreases in the strength of synaptic ...
Adeniyi, Philip A., Ali, Nilufar, Amini, Elham, Blumrich, Eva Maria, Datusalia, Ashok K., Fontanet, Paula, García Romero, Ezra Michelet, Ghosh, Shampa, Golpich, Mojtaba, Hegemann, Regina U., Jain, Vishal, Jamwal, Sumit, Joshi, Pooja, Kushwah, Neetu, Lepeta, Katarzyna, Loke, Hannah, Lourenco, Mychael V., Nawrotek, Katarzyna, Paid, Ramesh K., Pastor, Verónica, Piermartiri, Tetsade, Rotermund, Carola, Saini, Vedangana, Salamian, Ahmad, Schaefer, Natascha, Shahidzadeh, Sheila M., Sharma, Mahima, Sharma, Sorabh, Sinha, Jitendra K., Suárez Pozos, Edna, Turner, Anthony J., Vafadari, Benham, Wilson, Yvette   +32 more
core   +2 more sources

Transmembrane protein 108 involves in adult neurogenesis in the hippocampal dentate gyrus

Cell & Bioscience, 2019
Background Transmembrane protein 108 (Tmem108) is a risk gene of psychiatric diseases including schizophrenia, bipolar disorder and major depression disorder. However, the pathophysiological mechanisms of Tmem108 are largely unknown.
Zheng Yu, Dong Lin, Yanzi Zhong, Bin Luo, Shengsheng Liu, Erkang Fei, Xinsheng Lai, Suqi Zou, Shunqi Wang   +8 more
doaj   +1 more source

Learning with Delayed Synaptic Plasticity [PDF]

, 2019
The plasticity property of biological neural networks allows them to perform learning and optimize their behavior by changing their configuration. Inspired by biology, plasticity can be modeled in artificial neural networks by using Hebbian learning ...
Fletcher, George, Iacca, Giovanni, Mocanu, Decebal Constantin, Pechenizkiy, Mykola, Yaman, Anil   +4 more
core   +2 more sources

Coordinated activation of distinct Ca2+ sources and metabotropic glutamate receptors encodes Hebbian synaptic plasticity

Nature Communications, 2016
During STDP, the magnitude of postsynaptic Ca2+transients is hypothesized to determine the strength of synaptic plasticity. Here, the authors find that STDP in mature hippocampal synapses does not obey this rule but instead relies on the coordinated ...
Cezar M. Tigaret, Valeria Olivo, Josef H.L.P. Sadowski, Michael C. Ashby, Jack R. Mellor   +4 more
doaj   +1 more source

An integrated, temporal study of the behavioural, electrophysiological and neuropathological consequences of murine prion disease

Neurobiology of Disease, 2006
We have conducted an integrated study of ME7 prion disease by examining the electrophysiological and neuropathological features of hippocampal slices from behaviourally characterised C57Bl/6J mice 12, 14, 16, 18, 20 and 24 weeks after intracerebral micro-
Z. Chiti, O.M. Knutsen, S. Betmouni, J.R.T. Greene   +3 more
doaj   +1 more source

The Effect of Different Forms of Synaptic Plasticity on Pattern Recognition in the Cerebellar Cortex [PDF]

, 2009
“The original publication is available at www.springerlink.com”. Copyright Springer.Many cerebellar learning theories assume that long-term depression (LTD) of synapses between parallel fibres (PFs) and Purkinje cells (PCs) provides the basis for pattern
Adams, R.G., Davey, N., de Sousa, G., Maex, R., Steuber, Volker   +4 more
core   +1 more source

Local circuit allowing hypothalamic control of hippocampal area CA2 activity and consequences for CA1

eLife, 2021
The hippocampus is critical for memory formation. The hypothalamic supramammillary nucleus (SuM) sends long-range projections to hippocampal area CA2. While the SuM-CA2 connection is critical for social memory, how this input acts on the local circuit is
Vincent Robert, Ludivine Therreau, Vivien Chevaleyre, Eude Lepicard, Cécile Viollet, Julie Cognet, Arthur JY Huang, Roman Boehringer, Denis Polygalov, Thomas J McHugh, Rebecca Ann Piskorowski   +10 more
doaj   +1 more source

Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output

Nature Communications, 2020
Inhibitory interneuron subtypes differentially control place cell representations in CA1. Here, the authors show that parvalbumin and somatostatin interneuron synapses onto CA1 pyramidal neurons exhibit distinct plasticity mechanisms and incorporating ...
Matt Udakis, Victor Pedrosa, Sophie E. L. Chamberlain, Claudia Clopath, Jack R. Mellor   +4 more
doaj   +1 more source

Synaptic plasticity through activation of GluA3-containing AMPA-receptors

eLife, 2017
Excitatory synaptic transmission is mediated by AMPA-type glutamate receptors (AMPARs). In CA1 pyramidal neurons of the hippocampus two types of AMPARs predominate: those that contain subunits GluA1 and GluA2 (GluA1/2), and those that contain GluA2 and ...
Maria C Renner, Eva HH Albers, Nicolas Gutierrez-Castellanos, Niels R Reinders, Aile N van Huijstee, Hui Xiong, Tessa R Lodder, Helmut W Kessels   +7 more
doaj   +1 more source

Linking spontaneous and stimulated spine dynamics

Communications Biology, 2023
Our brains continuously acquire and store memories through synaptic plasticity. However, spontaneous synaptic changes can also occur and pose a challenge for maintaining stable memories.
Maximilian F. Eggl, Thomas E. Chater, Janko Petkovic, Yukiko Goda, Tatjana Tchumatchenko   +4 more
doaj   +1 more source