Results 21 to 30 of about 166,824 (164)

An integrated, temporal study of the behavioural, electrophysiological and neuropathological consequences of murine prion disease

Neurobiology of Disease, 2006
We have conducted an integrated study of ME7 prion disease by examining the electrophysiological and neuropathological features of hippocampal slices from behaviourally characterised C57Bl/6J mice 12, 14, 16, 18, 20 and 24 weeks after intracerebral micro-
Z. Chiti, O.M. Knutsen, S. Betmouni, J.R.T. Greene   +3 more
doaj   +1 more source

Local circuit allowing hypothalamic control of hippocampal area CA2 activity and consequences for CA1

eLife, 2021
The hippocampus is critical for memory formation. The hypothalamic supramammillary nucleus (SuM) sends long-range projections to hippocampal area CA2. While the SuM-CA2 connection is critical for social memory, how this input acts on the local circuit is
Vincent Robert, Ludivine Therreau, Vivien Chevaleyre, Eude Lepicard, Cécile Viollet, Julie Cognet, Arthur JY Huang, Roman Boehringer, Denis Polygalov, Thomas J McHugh, Rebecca Ann Piskorowski   +10 more
doaj   +1 more source

Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output

Nature Communications, 2020
Inhibitory interneuron subtypes differentially control place cell representations in CA1. Here, the authors show that parvalbumin and somatostatin interneuron synapses onto CA1 pyramidal neurons exhibit distinct plasticity mechanisms and incorporating ...
Matt Udakis, Victor Pedrosa, Sophie E. L. Chamberlain, Claudia Clopath, Jack R. Mellor   +4 more
doaj   +1 more source

Linking spontaneous and stimulated spine dynamics

Communications Biology, 2023
Our brains continuously acquire and store memories through synaptic plasticity. However, spontaneous synaptic changes can also occur and pose a challenge for maintaining stable memories.
Maximilian F. Eggl, Thomas E. Chater, Janko Petkovic, Yukiko Goda, Tatjana Tchumatchenko   +4 more
doaj   +1 more source

Synaptic plasticity through activation of GluA3-containing AMPA-receptors

eLife, 2017
Excitatory synaptic transmission is mediated by AMPA-type glutamate receptors (AMPARs). In CA1 pyramidal neurons of the hippocampus two types of AMPARs predominate: those that contain subunits GluA1 and GluA2 (GluA1/2), and those that contain GluA2 and ...
Maria C Renner, Eva HH Albers, Nicolas Gutierrez-Castellanos, Niels R Reinders, Aile N van Huijstee, Hui Xiong, Tessa R Lodder, Helmut W Kessels   +7 more
doaj   +1 more source

Neurodegenerative Disease: What Potential Therapeutic Role of Acid-Sensing Ion Channels?

Frontiers in Cellular Neuroscience, 2021
Acidic pH shift occurs in many physiological neuronal activities such as synaptic transmission and synaptic plasticity but also represents a characteristic feature of many pathological conditions including inflammation and ischemia.
Dalila Mango, Dalila Mango, Robert Nisticò, Robert Nisticò   +3 more
doaj   +1 more source

SUMOylation of FOXP1 regulates transcriptional repression via CtBP1 to drive dendritic morphogenesis

Scientific Reports, 2017
Forkhead Box P (FOXP) transcriptional repressors play a major role in brain development and their dysfunction leads to human cognitive disorders. However, little is known about how the activity of these proteins is regulated.
Daniel L. Rocca, Kevin A. Wilkinson, Jeremy M. Henley   +2 more
doaj   +1 more source

Assembly, Secretory Pathway Trafficking, and Surface Delivery of Kainate Receptors Is Regulated by Neuronal Activity

Cell Reports, 2017
Summary: Ionotropic glutamate receptor (iGluR) trafficking and function underpin excitatory synaptic transmission and plasticity and shape neuronal networks.
Ashley J. Evans, Sonam Gurung, Kevin A. Wilkinson, David J. Stephens, Jeremy M. Henley   +4 more
doaj   +1 more source

Endoplasmic reticulum visits highly active spines and prevents runaway potentiation of synapses

Nature Communications, 2020
In hippocampal pyramidal cells, a subset of dendritic spines contain endoplasmic reticulum (ER). Here, the authors show that ER enters dendritic spines in a non-random manner, during high synaptic activity with the function of limiting synaptic strength.
Alberto Perez-Alvarez, Shuting Yin, Christian Schulze, John A. Hammer, Wolfgang Wagner, Thomas G. Oertner   +5 more
doaj   +1 more source

Sharp-Wave Ripples Orchestrate the Induction of Synaptic Plasticity during Reactivation of Place Cell Firing Patterns in the Hippocampus

Cell Reports, 2016
Place cell firing patterns reactivated during hippocampal sharp-wave ripples (SWRs) in rest or sleep are thought to induce synaptic plasticity and thereby promote the consolidation of recently encoded information.
Josef H.L.P. Sadowski, Matthew W. Jones, Jack R. Mellor   +2 more
doaj   +1 more source