Results 21 to 30 of about 564,334 (388)

A mechanistic hypothesis for the impairment of synaptic plasticity by soluble Aβ oligomers from Alzheimer’s brain

Journal of Neurochemistry, 2020
It is increasingly accepted that early cognitive impairment in Alzheimer's disease results in considerable part from synaptic dysfunction caused by the accumulation of a range of oligomeric assemblies of amyloid β‐protein (Aβ).
Shaomin Li, D. Selkoe
semanticscholar   +1 more source

Paired associative stimulation demonstrates alterations in motor cortical synaptic plasticity in patients with hepatic encephalopathy [PDF]

Clinical Neurophysiology, Volume 132, Issue 10, October 2021, Pages 2332-2341, 2022
Objective: Hepatic encephalopathy (HE) is a potentially reversible brain dysfunction caused by liver failure. Altered synaptic plasticity is supposed to play a major role in the pathophysiology of HE. Here, we used paired associative stimulation with an inter-stimulus interval of 25 ms (PAS25), a transcranial magnetic stimulation (TMS) protocol, to ...
arxiv   +1 more source

Bidirectional synaptic plasticity rapidly modifies hippocampal representations

bioRxiv, 2020
Learning requires neural adaptations thought to be mediated by activity-dependent synaptic plasticity. A relatively non-standard form of synaptic plasticity driven by dendritic plateau potentials has been reported to underlie place field formation in ...
Aaron D. Milstein, Yiding Li, Katie C. Bittner, Christine Grienberger, I. Soltesz, J. Magee, S. Romani   +6 more
semanticscholar   +1 more source

Stress gates an astrocytic energy reservoir to impair synaptic plasticity

Nature Communications, 2020
Astrocytes support the energy demands of synaptic transmission and plasticity. Enduring changes in synaptic efficacy are highly sensitive to stress, yet whether changes to astrocyte bioenergetic control of synapses contributes to stress-impaired ...
Ciaran Murphy-Royal, April D. Johnston, A. K. Boyce, Blanca Díaz-Castro, A. Institoris, Govind Peringod, Oliver Zhang, Randy F. Stout, D. Spray, Roger J. Thompson, B. Khakh, J. Bains, G. Gordon   +12 more
semanticscholar   +1 more source

The C-terminal helix 9 motif in rat cannabinoid receptor type 1 regulates axonal trafficking and surface expression

eLife, 2019
Cannabinoid type one receptor (CB1R) is only stably surface expressed in axons, where it downregulates neurotransmitter release. How this tightly regulated axonal surface polarity is established and maintained is unclear.
Alexandra Fletcher-Jones, Keri L Hildick, Ashley J Evans, Yasuko Nakamura, Kevin A Wilkinson, Jeremy M Henley   +5 more
doaj   +1 more source

Astrocyte-secreted IL-33 mediates homeostatic synaptic plasticity in the adult hippocampus

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Synaptic plasticity in the hippocampus is important for learning and memory formation. In particular, homeostatic synaptic plasticity enables neurons to restore their activity levels in response to chronic neuronal activity changes.
Ye Wang, W. Fu, Kit Cheung, K. Hung, Congping Chen, Hongyan Geng, W. Yung, J. Qu, A. Fu, N. Ip   +9 more
semanticscholar   +1 more source

Cadherins and synaptic plasticity

Current Opinion in Cell Biology, 2008
Given their trans-synaptic localization, their persistent expression at mature synapses and their distinct biochemical and adhesive properties, cadherins are uniquely poised at the synapse to mediate synaptic plasticity, the ability to change synaptic function thought to underlie learning and memory.
Tai, Chin-Yin, Kim, Sally A., Schuman, Erin M.   +2 more
openaire   +6 more sources

Ca2+ and synaptic plasticity

Cell Calcium, 2005
The induction and maintenance of synaptic plasticity is well established to be a Ca2+-dependent process. The use of fluorescent imaging to monitor changes [Ca2+]i in neurones has revealed a diverse array of signaling patterns across the different compartments of the cell.
Cavazzini, M, Bliss, T, Emptage, N
openaire   +4 more sources

Sustained postsynaptic kainate receptor activation downregulates AMPA receptor surface expression and induces hippocampal LTD

iScience, 2021
Summary: It is well established that long-term depression (LTD) can be initiated by either NMDA or mGluR activation. Here we report that sustained activation of GluK2 subunit-containing kainate receptors (KARs) leads to α-amino-3-hydroxy-5-methyl-4 ...
Jithin D. Nair, Ellen Braksator, Busra P. Yucel, Alexandra Fletcher-Jones, Richard Seager, Jack R. Mellor, Zafar I. Bashir, Kevin A. Wilkinson, Jeremy M. Henley   +8 more
doaj  

The Candidate Schizophrenia Risk Gene Tmem108 Regulates Glucose Metabolism Homeostasis

Frontiers in Endocrinology, 2021
BackgroundSchizophrenia (SCZ) is a severe psychiatric disease affected by genetic factors and environmental contributors, and premorbid abnormality of glucose metabolism is one of the SCZ characteristics supposed to contribute to the disease’s ...
Jianbo Yu, Xufeng Liao, Yanzi Zhong, Yanzi Zhong, Yongqiang Wu, Xinsheng Lai, Xinsheng Lai, Huifeng Jiao, Min Yan, Yu Zhang, Chaolin Ma, Chaolin Ma, Shunqi Wang, Shunqi Wang   +13 more
doaj   +1 more source