Results 21 to 30 of about 571,868 (347)

Metformin Increases Sarcolemma Integrity and Ameliorates Neuromuscular Deficits in a Murine Model of Duchenne Muscular Dystrophy

Frontiers in Physiology, 2021
Duchenne muscular dystrophy (DMD) is a genetic neuromuscular disease characterized by progressive muscle weakness and wasting. Stimulation of AMP-activated protein kinase (AMPK) has been demonstrated to increase muscle function and protect muscle against
Xia Dong, Xia Dong, Tiankun Hui, Tiankun Hui, Jie Chen, Jie Chen, Zheng Yu, Dongyan Ren, Dongyan Ren, Suqi Zou, Suqi Zou, Shunqi Wang, Shunqi Wang, Erkang Fei, Erkang Fei, Huifeng Jiao, Xinsheng Lai, Xinsheng Lai   +17 more
doaj   +1 more source

A mechanistic hypothesis for the impairment of synaptic plasticity by soluble Aβ oligomers from Alzheimer’s brain

Journal of Neurochemistry, 2020
It is increasingly accepted that early cognitive impairment in Alzheimer's disease results in considerable part from synaptic dysfunction caused by the accumulation of a range of oligomeric assemblies of amyloid β‐protein (Aβ).
Shaomin Li, D. Selkoe
semanticscholar   +1 more source

Bidirectional synaptic plasticity rapidly modifies hippocampal representations

bioRxiv, 2020
Learning requires neural adaptations thought to be mediated by activity-dependent synaptic plasticity. A relatively non-standard form of synaptic plasticity driven by dendritic plateau potentials has been reported to underlie place field formation in ...
Aaron D. Milstein, Yiding Li, Katie C. Bittner, Christine Grienberger, I. Soltesz, J. Magee, S. Romani   +6 more
semanticscholar   +1 more source

Stress gates an astrocytic energy reservoir to impair synaptic plasticity

Nature Communications, 2020
Astrocytes support the energy demands of synaptic transmission and plasticity. Enduring changes in synaptic efficacy are highly sensitive to stress, yet whether changes to astrocyte bioenergetic control of synapses contributes to stress-impaired ...
Ciaran Murphy-Royal, April D. Johnston, A. K. Boyce, Blanca Díaz-Castro, A. Institoris, Govind Peringod, Oliver Zhang, Randy F. Stout, D. Spray, Roger J. Thompson, B. Khakh, J. Bains, G. Gordon   +12 more
semanticscholar   +1 more source

The C-terminal helix 9 motif in rat cannabinoid receptor type 1 regulates axonal trafficking and surface expression

eLife, 2019
Cannabinoid type one receptor (CB1R) is only stably surface expressed in axons, where it downregulates neurotransmitter release. How this tightly regulated axonal surface polarity is established and maintained is unclear.
Alexandra Fletcher-Jones, Keri L Hildick, Ashley J Evans, Yasuko Nakamura, Kevin A Wilkinson, Jeremy M Henley   +5 more
doaj   +1 more source

Astrocyte-secreted IL-33 mediates homeostatic synaptic plasticity in the adult hippocampus

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Synaptic plasticity in the hippocampus is important for learning and memory formation. In particular, homeostatic synaptic plasticity enables neurons to restore their activity levels in response to chronic neuronal activity changes.
Ye Wang, W. Fu, Kit Cheung, K. Hung, Congping Chen, Hongyan Geng, W. Yung, J. Qu, A. Fu, N. Ip   +9 more
semanticscholar   +1 more source

Cadherins and synaptic plasticity

Current Opinion in Cell Biology, 2008
Given their trans-synaptic localization, their persistent expression at mature synapses and their distinct biochemical and adhesive properties, cadherins are uniquely poised at the synapse to mediate synaptic plasticity, the ability to change synaptic function thought to underlie learning and memory.
Tai, Chin-Yin, Kim, Sally A., Schuman, Erin M.   +2 more
openaire   +6 more sources

Surface biotinylation of primary neurons to monitor changes in AMPA receptor surface expression in response to kainate receptor stimulation

STAR Protocols, 2021
Summary: Here, we detail a surface biotinylation technique used to label surface-expressed proteins in primary neuronal cultures. Surface proteins are labeled with membrane-impermeant Sulfo-NHS-SS-biotin, and isolated by pull-down with streptavidin beads
Jithin D. Nair, Jeremy M. Henley, Kevin A. Wilkinson   +2 more
doaj   +1 more source

Ca2+ and synaptic plasticity

Cell Calcium, 2005
The induction and maintenance of synaptic plasticity is well established to be a Ca2+-dependent process. The use of fluorescent imaging to monitor changes [Ca2+]i in neurones has revealed a diverse array of signaling patterns across the different compartments of the cell.
Cavazzini, M, Bliss, T, Emptage, N
openaire   +4 more sources

Ubiquitin activates synaptic plasticity [PDF]

Nature Reviews Neuroscience, 2012
NEURL1A-mediated ubiquitylation of CPEB3 alters its activity and regulates hippocampal synaptic plasticity and memory formation.
openaire   +3 more sources