Results 31 to 40 of about 564,334 (388)
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models
Nature Network Boston, 2018 Defective brain hormonal signaling has been associated with Alzheimer’s disease (AD), a disorder characterized by synapse and memory failure. Irisin is an exercise-induced myokine released on cleavage of the membrane-bound precursor protein fibronectin ...
Mychael V. Lourenco +24 more
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Frontiers in Synaptic Neuroscience, 2020 Experience-dependent learning and memory require multiple forms of plasticity at hippocampal and cortical synapses that are regulated by N-methyl-D-aspartate receptors (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type ionotropic
Alicia M. Purkey, M. Dell’Acqua
semanticscholar +1 more source
Ubiquitin activates synaptic plasticity [PDF]
Nature Reviews Neuroscience, 2012 NEURL1A-mediated ubiquitylation of CPEB3 alters its activity and regulates hippocampal synaptic plasticity and memory formation.
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GluK2 Q/R editing regulates kainate receptor signaling and long-term potentiation of AMPA receptors
iScience, 2023 Summary: Q/R editing of the kainate receptor (KAR) subunit GluK2 radically alters recombinant KAR properties, but the effects on endogenous KARs in vivo remain largely unexplored.
Jithin D. Nair +6 more
doaj
Fluctuation in background synaptic activity controls synaptic plasticity [PDF]
arXiv, 2021 Synaptic plasticity is vital for learning and memory in the brain. It consists of long-term potentiation (LTP) and long-term depression (LTD). Spike frequency is one of the major components of synaptic plasticity in the brain, a noisy environment. Recently, we mathematically analysed the frequency-dependent synaptic plasticity (FDP) in vivo and found ...
arxiv
MAGUKs, Synaptic Development, and Synaptic Plasticity [PDF]
The Neuroscientist, 2011 MAGUKs are proteins that act as key scaffolds in surface complexes containing receptors, adhesion proteins, and various signaling molecules. These complexes evolved prior to the appearance of multicellular animals and play key roles in cell-cell intercommunication. A major example of this is the neuronal synapse, which contains several presynaptic and
Gail K. Seabold +3 more
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Transmembrane protein 108 involves in adult neurogenesis in the hippocampal dentate gyrus
Cell & Bioscience, 2019 Background Transmembrane protein 108 (Tmem108) is a risk gene of psychiatric diseases including schizophrenia, bipolar disorder and major depression disorder. However, the pathophysiological mechanisms of Tmem108 are largely unknown.
Zheng Yu +8 more
doaj +1 more source
The epitranscriptome and synaptic plasticity
Current Opinion in Neurobiology, 2019 RNA modifications, collectively referred to as 'the epitranscriptome,' have recently emerged as a pervasive feature of cellular mRNAs which have diverse impacts on gene expression. In the last several years, technological advances improving our ability to identify mRNA modifications, coupled with the discovery of proteins that add and remove these ...
Mathieu N Flamand, Kate D Meyer
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Energy efficient synaptic plasticity [PDF]
eLife, 2019 Many aspects of the brain’s design can be understood as the result of evolutionary drive toward metabolic efficiency. In addition to the energetic costs of neural computation and transmission, experimental evidence indicates that synaptic plasticity is metabolically demanding as well. As synaptic plasticity is crucial for learning, we examine how these
Ho Ling Li, Mark CW van Rossum
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Novelty producing synaptic plasticity [PDF]
Proceedings of the 2020 Genetic and Evolutionary Computation Conference Companion, 2020 A learning process with the plasticity property often requires reinforcement signals to guide the process. However, in some tasks (e.g. maze-navigation), it is very difficult (or impossible) to measure the performance of an agent (i.e. a fitness value) to provide reinforcements since the position of the goal is not known.
Yaman, Anil +4 more
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