Results 31 to 40 of about 571,868 (347)
Astrocytes: Orchestrating synaptic plasticity? [PDF]
Neuroscience, 2016 63 pages, 4 ...
M. De Pittà +3 more
openaire +6 more sources
Kainate receptors and synaptic plasticity [PDF]
Neuropharmacology, 2021 Synaptic plasticity has classically been characterized to involve the NMDA and AMPA subtypes of glutamate receptors, with NMDA receptors providing the key trigger for the induction of long-term plasticity leading to changes in AMPA receptor expression.
Jithin D. Nair +3 more
openaire +3 more sources
The Candidate Schizophrenia Risk Gene Tmem108 Regulates Glucose Metabolism Homeostasis
Frontiers in Endocrinology, 2021 BackgroundSchizophrenia (SCZ) is a severe psychiatric disease affected by genetic factors and environmental contributors, and premorbid abnormality of glucose metabolism is one of the SCZ characteristics supposed to contribute to the disease’s ...
Jianbo Yu +13 more
doaj +1 more source
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models
Nature Network Boston, 2018 Defective brain hormonal signaling has been associated with Alzheimer’s disease (AD), a disorder characterized by synapse and memory failure. Irisin is an exercise-induced myokine released on cleavage of the membrane-bound precursor protein fibronectin ...
Mychael V. Lourenco +24 more
semanticscholar +1 more source
Frontiers in Synaptic Neuroscience, 2020 Experience-dependent learning and memory require multiple forms of plasticity at hippocampal and cortical synapses that are regulated by N-methyl-D-aspartate receptors (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type ionotropic
Alicia M. Purkey, M. Dell’Acqua
semanticscholar +1 more source
MAGUKs, Synaptic Development, and Synaptic Plasticity [PDF]
The Neuroscientist, 2011 MAGUKs are proteins that act as key scaffolds in surface complexes containing receptors, adhesion proteins, and various signaling molecules. These complexes evolved prior to the appearance of multicellular animals and play key roles in cell-cell intercommunication. A major example of this is the neuronal synapse, which contains several presynaptic and
Gail K. Seabold +3 more
openaire +3 more sources
Transmembrane protein 108 involves in adult neurogenesis in the hippocampal dentate gyrus
Cell & Bioscience, 2019 Background Transmembrane protein 108 (Tmem108) is a risk gene of psychiatric diseases including schizophrenia, bipolar disorder and major depression disorder. However, the pathophysiological mechanisms of Tmem108 are largely unknown.
Zheng Yu +8 more
doaj +1 more source
Energy efficient synaptic plasticity [PDF]
eLife, 2019 Many aspects of the brain’s design can be understood as the result of evolutionary drive toward metabolic efficiency. In addition to the energetic costs of neural computation and transmission, experimental evidence indicates that synaptic plasticity is metabolically demanding as well. As synaptic plasticity is crucial for learning, we examine how these
Ho Ling Li, Mark CW van Rossum
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Novelty producing synaptic plasticity [PDF]
Proceedings of the 2020 Genetic and Evolutionary Computation Conference Companion, 2020 A learning process with the plasticity property often requires reinforcement signals to guide the process. However, in some tasks (e.g. maze-navigation), it is very difficult (or impossible) to measure the performance of an agent (i.e. a fitness value) to provide reinforcements since the position of the goal is not known.
Yaman, Anil +4 more
openaire +2 more sources
Nature Communications, 2016 During STDP, the magnitude of postsynaptic Ca2+transients is hypothesized to determine the strength of synaptic plasticity. Here, the authors find that STDP in mature hippocampal synapses does not obey this rule but instead relies on the coordinated ...
Cezar M. Tigaret +4 more
doaj +1 more source