The Spacing Effect for Structural Synaptic Plasticity Provides Specificity and Precision in Plastic Changes [PDF]
, 2017 In contrast to trials of training without intervals (massed training), training trials spaced over time (spaced training) induce a more persistent memory identified as long-term memory (LTM).
Gelb, Bruce +3 more
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Gravin orchestrates protein kinase A and 2-adrenergic receptor signaling critical for synaptic plasticity and memory [PDF]
, 2012 A kinase-anchoring proteins (AKAPs) organize compartmentalized pools of protein kinase A (PKA) to enable localized signaling events within neurons. However, it is unclear which of the many expressed AKAPs in neurons target PKA to signaling complexes ...
Abel, T. +12 more
core +2 more sources
The Candidate Schizophrenia Risk Gene Tmem108 Regulates Glucose Metabolism Homeostasis
Frontiers in Endocrinology, 2021 BackgroundSchizophrenia (SCZ) is a severe psychiatric disease affected by genetic factors and environmental contributors, and premorbid abnormality of glucose metabolism is one of the SCZ characteristics supposed to contribute to the disease’s ...
Jianbo Yu +13 more
doaj +1 more source
Interactions between short-term and long-term plasticity: shooting for a moving target [PDF]
, 2011 Far from being static transmission units, synapses are highly dynamical elements that change over multiple time scales depending on the history of the neural activity of both the pre- and postsynaptic neuron.
Jean-Pascal Pfister, Má
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Neurodegenerative Disease: What Potential Therapeutic Role of Acid-Sensing Ion Channels?
Frontiers in Cellular Neuroscience, 2021 Acidic pH shift occurs in many physiological neuronal activities such as synaptic transmission and synaptic plasticity but also represents a characteristic feature of many pathological conditions including inflammation and ischemia.
Dalila Mango +3 more
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Temporal Map Formation in the Barn Owl’s Brain [PDF]
, 2001 Barn owls provide an experimentally well-specified example of a temporal map, a neuronal representation of the outside world in the brain by means of time. Their laminar nucleus exhibits a place code of interaural time differences, a cue which is used to
Hemmen, Jan Leo van +2 more
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Alterations in brain connectivity due to plasticity and synaptic delay
, 2017 Brain plasticity refers to brain's ability to change neuronal connections, as a result of environmental stimuli, new experiences, or damage. In this work, we study the effects of the synaptic delay on both the coupling strengths and synchronisation in a ...
Batista, A. M. +8 more
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SUMOylation of FOXP1 regulates transcriptional repression via CtBP1 to drive dendritic morphogenesis
Scientific Reports, 2017 Forkhead Box P (FOXP) transcriptional repressors play a major role in brain development and their dysfunction leads to human cognitive disorders. However, little is known about how the activity of these proteins is regulated.
Daniel L. Rocca +2 more
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Cell Reports, 2017 Summary: Ionotropic glutamate receptor (iGluR) trafficking and function underpin excitatory synaptic transmission and plasticity and shape neuronal networks.
Ashley J. Evans +4 more
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Endoplasmic reticulum visits highly active spines and prevents runaway potentiation of synapses
Nature Communications, 2020 In hippocampal pyramidal cells, a subset of dendritic spines contain endoplasmic reticulum (ER). Here, the authors show that ER enters dendritic spines in a non-random manner, during high synaptic activity with the function of limiting synaptic strength.
Alberto Perez-Alvarez +5 more
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