Results 31 to 40 of about 166,824 (164)
Nature Communications, 2021 In this study, acetylcholine release is shown to reorganise hippocampal CA1 inhibitory networks resulting in prioritisation of entorhinal input over CA3 input. This is achieved by activation of a combination of M3 and M4 muscarinic receptors.
Jon Palacios-Filardo +7 more
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Novelty producing synaptic plasticity [PDF]
Proceedings of the 2020 Genetic and Evolutionary Computation Conference Companion, 2020 A learning process with the plasticity property often requires reinforcement signals to guide the process. However, in some tasks (e.g. maze-navigation), it is very difficult (or impossible) to measure the performance of an agent (i.e. a fitness value) to provide reinforcements since the position of the goal is not known.
Yaman, Anil +4 more
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Hippocampal-dependent navigation in head-fixed mice using a floating real-world environment
Scientific ReportsHead-fixation of mice enables high-resolution monitoring of neuronal activity coupled with precise control of environmental stimuli. Virtual reality can be used to emulate the visual experience of movement during head fixation, but a low inertia floating
Sarah A. Stuart +6 more
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Regional specificity of synaptic plasticity deficits in a knock-in mouse model of DYT1 dystonia
Neurobiology of Disease, 2014 DYT1 dystonia is a movement disorder caused by a deletion in the C-terminal of the protein torsinA. It is unclear how torsinA mutation might disrupt cellular processes encoding motor activity, and whether this impairment occurs in specific brain regions.
G. Martella +12 more
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Optogenetics and synaptic plasticity [PDF]
Acta Pharmacologica Sinica, 2013 The intricate and complex interaction between different populations of neurons in the brain has imposed limits on our ability to gain detailed understanding of synaptic transmission and its integration when employing classical electrophysiological approaches. Indeed, electrical field stimulation delivered via traditional microelectrodes does not permit
Yu-feng, Xie +2 more
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Caspases in synaptic plasticity [PDF]
Molecular Brain, 2012 Caspases are a family of cysteine proteases that play key roles in programmed cell death (apoptosis). Mounting evidence in recent years shows that caspases also have important non-apoptotic functions in multiple cellular processes, such as synaptic plasticity, dendritic development, learning and memory. In this article, we review the studies on the non-
Li Zheng, Sheng Morgan
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Neurobiology of DiseaseHuman beings are living longer than ever before and aging is accompanied by an increased incidence of motor deficits, including those associated with the neurodegenerative conditions, Parkinson's disease (PD) and Huntington's disease (HD).
Qiang Shan +3 more
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Ripples Make Waves: Binding Structured Activity and Plasticity in Hippocampal Networks
Neural Plasticity, 2011 Establishing novel episodic memories and stable spatial representations depends on an exquisitely choreographed, multistage process involving the online encoding and offline consolidation of sensory information, a process that is largely dependent on the
Josef H. L. P. Sadowski +2 more
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Synaptoimmunology - roles in health and disease
Molecular Brain, 2017 Mounting evidence suggests that the nervous and immune systems are intricately linked. Many proteins first identified in the immune system have since been detected at synapses, playing different roles in normal and pathological situations.
Robert Nisticò +8 more
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The roles of STP and LTP in synaptic encoding [PDF]
PeerJ, 2013 Long-term potentiation (LTP), a cellular model of learning and memory, is generally regarded as a unitary phenomenon that alters the strength of synaptic transmission by increasing the postsynaptic response to the release of a quantum of neurotransmitter.
Arturas Volianskis +2 more
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