Results 31 to 40 of about 724,295 (381)
Cadherins and synaptic plasticity
Current Opinion in Cell Biology, 2008 Given their trans-synaptic localization, their persistent expression at mature synapses and their distinct biochemical and adhesive properties, cadherins are uniquely poised at the synapse to mediate synaptic plasticity, the ability to change synaptic function thought to underlie learning and memory.
Tai, Chin-Yin +2 more
openaire +6 more sources
STAR Protocols, 2021 Summary: Here, we detail a surface biotinylation technique used to label surface-expressed proteins in primary neuronal cultures. Surface proteins are labeled with membrane-impermeant Sulfo-NHS-SS-biotin, and isolated by pull-down with streptavidin beads
Jithin D. Nair +2 more
doaj +1 more source
The Spacing Effect for Structural Synaptic Plasticity Provides Specificity and Precision in Plastic Changes [PDF]
, 2017 In contrast to trials of training without intervals (massed training), training trials spaced over time (spaced training) induce a more persistent memory identified as long-term memory (LTM).
Gelb, Bruce +3 more
core +1 more source
Synaptic plasticity rules with physiological calcium levels
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Spike-timing–dependent plasticity (STDP) is a form of synaptic modification thought to be a primary mechanism underlying formation of new memories.
Yanis Inglebert +3 more
semanticscholar +1 more source
Cell Calcium, 2005 The induction and maintenance of synaptic plasticity is well established to be a Ca2+-dependent process. The use of fluorescent imaging to monitor changes [Ca2+]i in neurones has revealed a diverse array of signaling patterns across the different compartments of the cell.
Cavazzini, M, Bliss, T, Emptage, N
openaire +4 more sources
Interactions between short-term and long-term plasticity: shooting for a moving target [PDF]
, 2011 Far from being static transmission units, synapses are highly dynamical elements that change over multiple time scales depending on the history of the neural activity of both the pre- and postsynaptic neuron.
Jean-Pascal Pfister, Má
core +2 more sources
Ubiquitin activates synaptic plasticity [PDF]
Nature Reviews Neuroscience, 2012 NEURL1A-mediated ubiquitylation of CPEB3 alters its activity and regulates hippocampal synaptic plasticity and memory formation.
openaire +3 more sources
Gravin orchestrates protein kinase A and 2-adrenergic receptor signaling critical for synaptic plasticity and memory [PDF]
, 2012 A kinase-anchoring proteins (AKAPs) organize compartmentalized pools of protein kinase A (PKA) to enable localized signaling events within neurons. However, it is unclear which of the many expressed AKAPs in neurons target PKA to signaling complexes ...
Abel, T. +12 more
core +2 more sources
The Candidate Schizophrenia Risk Gene Tmem108 Regulates Glucose Metabolism Homeostasis
Frontiers in Endocrinology, 2021 BackgroundSchizophrenia (SCZ) is a severe psychiatric disease affected by genetic factors and environmental contributors, and premorbid abnormality of glucose metabolism is one of the SCZ characteristics supposed to contribute to the disease’s ...
Jianbo Yu +13 more
doaj +1 more source
Astrocytes: Orchestrating synaptic plasticity? [PDF]
Neuroscience, 2016 63 pages, 4 ...
M. De Pittà +3 more
openaire +5 more sources