Results 41 to 50 of about 564,334 (388)
Nature Communications, 2016 During STDP, the magnitude of postsynaptic Ca2+transients is hypothesized to determine the strength of synaptic plasticity. Here, the authors find that STDP in mature hippocampal synapses does not obey this rule but instead relies on the coordinated ...
Cezar M. Tigaret +4 more
doaj +1 more source
A Spiking Neuron Synaptic Plasticity Model Optimized for Unsupervised Learning [PDF]
arXiv, 2021 Spiking neural networks (SNN) are considered as a perspective basis for performing all kinds of learning tasks - unsupervised, supervised and reinforcement learning. Learning in SNN is implemented through synaptic plasticity - the rules which determine dynamics of synaptic weights depending usually on activity of the pre- and post-synaptic neurons ...
arxiv
eLife, 2021 The hippocampus is critical for memory formation. The hypothalamic supramammillary nucleus (SuM) sends long-range projections to hippocampal area CA2. While the SuM-CA2 connection is critical for social memory, how this input acts on the local circuit is
Vincent Robert +10 more
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Synaptic Weight Distributions Depend on the Geometry of Plasticity [PDF]
The Twelfth International Conference on Learning Representations,
2024, 2023 A growing literature in computational neuroscience leverages gradient descent and learning algorithms that approximate it to study synaptic plasticity in the brain. However, the vast majority of this work ignores a critical underlying assumption: the choice of distance for synaptic changes - i.e. the geometry of synaptic plasticity.
arxiv
Synaptic plasticity through activation of GluA3-containing AMPA-receptors
eLife, 2017 Excitatory synaptic transmission is mediated by AMPA-type glutamate receptors (AMPARs). In CA1 pyramidal neurons of the hippocampus two types of AMPARs predominate: those that contain subunits GluA1 and GluA2 (GluA1/2), and those that contain GluA2 and ...
Maria C Renner +7 more
doaj +1 more source
Nature Communications, 2020 Inhibitory interneuron subtypes differentially control place cell representations in CA1. Here, the authors show that parvalbumin and somatostatin interneuron synapses onto CA1 pyramidal neurons exhibit distinct plasticity mechanisms and incorporating ...
Matt Udakis +4 more
doaj +1 more source
Neurodegenerative Disease: What Potential Therapeutic Role of Acid-Sensing Ion Channels?
Frontiers in Cellular Neuroscience, 2021 Acidic pH shift occurs in many physiological neuronal activities such as synaptic transmission and synaptic plasticity but also represents a characteristic feature of many pathological conditions including inflammation and ischemia.
Dalila Mango +3 more
doaj +1 more source
Multi-contact synapses for stable networks: a spike-timing dependent model of dendritic spine plasticity and turnover [PDF]
Cerebral Cortex 28-4 (2018) 1396-1415, 2016 Excitatory synaptic connections in the adult neocortex consist of multiple synaptic contacts, almost exclusively formed on dendritic spines. Changes of dendritic spine shape and volume, a correlate of synaptic strength, can be tracked in vivo for weeks.
arxiv +1 more source
Synaptic plasticity in schizophrenia pathophysiology
IBRO Neuroscience Reports, 2023 Schizophrenia is a severe neuropsychiatric syndrome with psychotic behavioral abnormalities and marked cognitive deficits. It is widely accepted that genetic and environmental factors contribute to the onset of schizophrenia. However, the etiology and pathology of the disease remain largely unexplored.
Kexuan Zhang +3 more
openaire +5 more sources
IBRO Neuroscience Reports, 2021 Botulinum neurotoxins (BoNTs) are extremely potent naturally occurring poisons that act by silencing neurotransmission. Intriguingly, in addition to preventing presynaptic vesicle fusion, BoNT serotype A (BoNT/A) can also promote axonal regeneration in ...
Luis Solabre Valois +6 more
doaj