Results 41 to 50 of about 571,868 (347)
Neurobiology of Disease, 2006 We have conducted an integrated study of ME7 prion disease by examining the electrophysiological and neuropathological features of hippocampal slices from behaviourally characterised C57Bl/6J mice 12, 14, 16, 18, 20 and 24 weeks after intracerebral micro-
Z. Chiti +3 more
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eLife, 2021 The hippocampus is critical for memory formation. The hypothalamic supramammillary nucleus (SuM) sends long-range projections to hippocampal area CA2. While the SuM-CA2 connection is critical for social memory, how this input acts on the local circuit is
Vincent Robert +10 more
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The epitranscriptome and synaptic plasticity
Current Opinion in Neurobiology, 2019 RNA modifications, collectively referred to as 'the epitranscriptome,' have recently emerged as a pervasive feature of cellular mRNAs which have diverse impacts on gene expression. In the last several years, technological advances improving our ability to identify mRNA modifications, coupled with the discovery of proteins that add and remove these ...
Mathieu N Flamand, Kate D Meyer
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Synaptic plasticity in schizophrenia pathophysiology
IBRO Neuroscience Reports, 2023 Schizophrenia is a severe neuropsychiatric syndrome with psychotic behavioral abnormalities and marked cognitive deficits. It is widely accepted that genetic and environmental factors contribute to the onset of schizophrenia. However, the etiology and pathology of the disease remain largely unexplored.
Kexuan Zhang +3 more
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Synaptic plasticity through activation of GluA3-containing AMPA-receptors
eLife, 2017 Excitatory synaptic transmission is mediated by AMPA-type glutamate receptors (AMPARs). In CA1 pyramidal neurons of the hippocampus two types of AMPARs predominate: those that contain subunits GluA1 and GluA2 (GluA1/2), and those that contain GluA2 and ...
Maria C Renner +7 more
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Nature Communications, 2020 Inhibitory interneuron subtypes differentially control place cell representations in CA1. Here, the authors show that parvalbumin and somatostatin interneuron synapses onto CA1 pyramidal neurons exhibit distinct plasticity mechanisms and incorporating ...
Matt Udakis +4 more
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Linking spontaneous and stimulated spine dynamics
Communications Biology, 2023 Our brains continuously acquire and store memories through synaptic plasticity. However, spontaneous synaptic changes can also occur and pose a challenge for maintaining stable memories.
Maximilian F. Eggl +4 more
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Neurodegenerative Disease: What Potential Therapeutic Role of Acid-Sensing Ion Channels?
Frontiers in Cellular Neuroscience, 2021 Acidic pH shift occurs in many physiological neuronal activities such as synaptic transmission and synaptic plasticity but also represents a characteristic feature of many pathological conditions including inflammation and ischemia.
Dalila Mango +3 more
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Endoplasmic reticulum visits highly active spines and prevents runaway potentiation of synapses
Nature Communications, 2020 In hippocampal pyramidal cells, a subset of dendritic spines contain endoplasmic reticulum (ER). Here, the authors show that ER enters dendritic spines in a non-random manner, during high synaptic activity with the function of limiting synaptic strength.
Alberto Perez-Alvarez +5 more
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Synaptic plasticity and phosphorylation [PDF]
Pharmacology & Therapeutics, 2006 A number of neuronal functions, including synaptic plasticity, depend on proper regulation of synaptic proteins, many of which can be rapidly regulated by phosphorylation. Neuronal activity controls the function of these synaptic proteins by exquisitely regulating the balance of various protein kinase and protein phosphatase activity.
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