Results 41 to 50 of about 724,295 (381)

Kainate receptors and synaptic plasticity [PDF]

Neuropharmacology, 2021
Synaptic plasticity has classically been characterized to involve the NMDA and AMPA subtypes of glutamate receptors, with NMDA receptors providing the key trigger for the induction of long-term plasticity leading to changes in AMPA receptor expression.
Jithin D. Nair, Kevin A. Wilkinson, Jeremy M. Henley, Jack R. Mellor   +3 more
openaire   +3 more sources

The malleable brain: plasticity of neural circuits and behavior: A review from students to students [PDF]

, 2017
One of the most intriguing features of the brain is its ability to be malleable, allowing it to adapt continually to changes in the environment. Specific neuronal activity patterns drive long-lasting increases or decreases in the strength of synaptic ...
Adeniyi, Philip A., Ali, Nilufar, Amini, Elham, Blumrich, Eva Maria, Datusalia, Ashok K., Fontanet, Paula, García Romero, Ezra Michelet, Ghosh, Shampa, Golpich, Mojtaba, Hegemann, Regina U., Jain, Vishal, Jamwal, Sumit, Joshi, Pooja, Kushwah, Neetu, Lepeta, Katarzyna, Loke, Hannah, Lourenco, Mychael V., Nawrotek, Katarzyna, Paid, Ramesh K., Pastor, Verónica, Piermartiri, Tetsade, Rotermund, Carola, Saini, Vedangana, Salamian, Ahmad, Schaefer, Natascha, Shahidzadeh, Sheila M., Sharma, Mahima, Sharma, Sorabh, Sinha, Jitendra K., Suárez Pozos, Edna, Turner, Anthony J., Vafadari, Benham, Wilson, Yvette   +32 more
core   +2 more sources

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models

Nature Network Boston, 2018
Defective brain hormonal signaling has been associated with Alzheimer’s disease (AD), a disorder characterized by synapse and memory failure. Irisin is an exercise-induced myokine released on cleavage of the membrane-bound precursor protein fibronectin ...
Mychael V. Lourenco, R. Frozza, Guilherme B. de Freitas, Hong Zhang, G. C. Kincheski, F. Ribeiro, R. A. Gonçalves, J. Clarke, Danielle Beckman, Agnieszka Staniszewski, Hanna Berman, Lorena A. Guerra, Letícia Forny‐Germano, Shelby Meier, D. Wilcock, Jorge M. de Souza, S. Alves‐Leon, V. Prado, M. Prado, J. Abisambra, F. Tovar-Moll, P. Mattos, O. Arancio, S. Ferreira, F. D. De Felice   +24 more
semanticscholar   +1 more source

MAGUKs, Synaptic Development, and Synaptic Plasticity [PDF]

The Neuroscientist, 2011
MAGUKs are proteins that act as key scaffolds in surface complexes containing receptors, adhesion proteins, and various signaling molecules. These complexes evolved prior to the appearance of multicellular animals and play key roles in cell-cell intercommunication. A major example of this is the neuronal synapse, which contains several presynaptic and
Gail K. Seabold, Martin Horak, Ronald S. Petralia, Chan-Ying Zheng   +3 more
openaire   +3 more sources

Phosphorylation-Dependent Regulation of Ca2+-Permeable AMPA Receptors During Hippocampal Synaptic Plasticity

Frontiers in Synaptic Neuroscience, 2020
Experience-dependent learning and memory require multiple forms of plasticity at hippocampal and cortical synapses that are regulated by N-methyl-D-aspartate receptors (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type ionotropic
Alicia M. Purkey, M. Dell’Acqua
semanticscholar   +1 more source

Transmembrane protein 108 involves in adult neurogenesis in the hippocampal dentate gyrus

Cell & Bioscience, 2019
Background Transmembrane protein 108 (Tmem108) is a risk gene of psychiatric diseases including schizophrenia, bipolar disorder and major depression disorder. However, the pathophysiological mechanisms of Tmem108 are largely unknown.
Zheng Yu, Dong Lin, Yanzi Zhong, Bin Luo, Shengsheng Liu, Erkang Fei, Xinsheng Lai, Suqi Zou, Shunqi Wang   +8 more
doaj   +1 more source

Energy efficient synaptic plasticity [PDF]

eLife, 2019
Many aspects of the brain’s design can be understood as the result of evolutionary drive toward metabolic efficiency. In addition to the energetic costs of neural computation and transmission, experimental evidence indicates that synaptic plasticity is metabolically demanding as well. As synaptic plasticity is crucial for learning, we examine how these
Ho Ling Li, Mark CW van Rossum
openaire   +5 more sources

Novelty producing synaptic plasticity [PDF]

Proceedings of the 2020 Genetic and Evolutionary Computation Conference Companion, 2020
A learning process with the plasticity property often requires reinforcement signals to guide the process. However, in some tasks (e.g. maze-navigation), it is very difficult (or impossible) to measure the performance of an agent (i.e. a fitness value) to provide reinforcements since the position of the goal is not known.
Yaman, Anil, Iacca, Giovanni, Mocanu, Decebal Constantin, Fletcher, George, Pechenizkiy, Mykola   +4 more
openaire   +2 more sources

Coordinated activation of distinct Ca2+ sources and metabotropic glutamate receptors encodes Hebbian synaptic plasticity

Nature Communications, 2016
During STDP, the magnitude of postsynaptic Ca2+transients is hypothesized to determine the strength of synaptic plasticity. Here, the authors find that STDP in mature hippocampal synapses does not obey this rule but instead relies on the coordinated ...
Cezar M. Tigaret, Valeria Olivo, Josef H.L.P. Sadowski, Michael C. Ashby, Jack R. Mellor   +4 more
doaj   +1 more source

An integrated, temporal study of the behavioural, electrophysiological and neuropathological consequences of murine prion disease

Neurobiology of Disease, 2006
We have conducted an integrated study of ME7 prion disease by examining the electrophysiological and neuropathological features of hippocampal slices from behaviourally characterised C57Bl/6J mice 12, 14, 16, 18, 20 and 24 weeks after intracerebral micro-
Z. Chiti, O.M. Knutsen, S. Betmouni, J.R.T. Greene   +3 more
doaj   +1 more source