Results 41 to 50 of about 166,824 (164)
Unbiased choice of global clustering parameters for single-molecule localization microscopy
Scientific Reports, 2022 Single-molecule localization microscopy resolves objects below the diffraction limit of light via sparse, stochastic detection of target molecules. Single molecules appear as clustered detection events after image reconstruction.
Pietro Verzelli +5 more
doaj +1 more source
Developmental and Activity Dependent Regulation of Ionotropic Glutamate Receptors at Synapses
The Scientific World Journal, 2002 Glutamate receptors mediate the majority of excitatory responses in the central nervous system. The establishment and refinement of glutamatergic synaptic connections depend on the concerted actions of a-amino-3-hydroxy-5-methyl-isoxazole-4-propionate ...
Elek Molnar, John T.R. Isaac
doaj +1 more source
Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations
Nature Communications, 2020 The main cell types involved in autism spectrum disorders through elevated protein synthesis are not well identified. Here, the authors show that overexpression of translation initiation factor eIF4E in microglia results in autism-like behaviour in male,
Zhi-Xiang Xu +15 more
doaj +1 more source
Proteins Involved in the Trafficking and Functional Synaptic Expression of AMPA and KA Receptors
The Scientific World Journal, 2002 α-Amino-3-hydroxy-5-methylisoxazolepropionate receptors (AMPARs) mediate the majority of fast synaptic transmission in the mammalian central nervous system, play a central role in synapse stabilisation and plasticity, and their prolonged activation is ...
Sarah A. De La Rue, Jeremy M. Henley
doaj +1 more source
Synaptic plasticity: Neighborhood influences [PDF]
Current Biology, 1997 Recent studies indicate that, when the strengths of specific synapses are modified by activity, changes in strengths also occur at neighboring synapses; this neighborhood influence has important implications for how synaptic modifications implement learning and memory.
openaire +2 more sources
Translational concepts of mGluR5 in synaptic diseases of the brain
Frontiers in Pharmacology, 2012 The G-protein coupled receptor family of glutamate receptors, termed metabotropic glutamate receptors (mGluRs), are implicated in numerous cellular mechanisms ranging from neural development to the processing of cognitive, sensory, and motor information.
Thomas M Piers +9 more
doaj +1 more source
Synaptic plasticity and phosphorylation [PDF]
Pharmacology & Therapeutics, 2006 A number of neuronal functions, including synaptic plasticity, depend on proper regulation of synaptic proteins, many of which can be rapidly regulated by phosphorylation. Neuronal activity controls the function of these synaptic proteins by exquisitely regulating the balance of various protein kinase and protein phosphatase activity.
openaire +2 more sources
STAR ProtocolsSummary: Here, we present an optimized acyl-PEGyl exchange gel shift (APEGS) assay to monitor palmitoylation of high-molecular-weight proteins from primary neuronal cultures.
Busra Perihan Yucel +2 more
doaj +1 more source
Energy efficient synaptic plasticity
eLife, 2019 Many aspects of the brain’s design can be understood as the result of evolutionary drive toward metabolic efficiency. In addition to the energetic costs of neural computation and transmission, experimental evidence indicates that synaptic plasticity is metabolically demanding as well. As synaptic plasticity is crucial for learning, we examine how these
Ho Ling Li, Mark CW van Rossum
openaire +4 more sources
Translational PsychiatryMicroglia, traditionally regarded as innate immune cells in the brain, drive neuroinflammation and synaptic dysfunctions in the early phases of Alzheimer disease (AD), acting upstream to Aβ accumulation.
Gaia Piccioni +6 more
doaj +1 more source